Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
209-544-5
CAS no.:
584-84-9
Index number:
Molecular formula:
C9H6N2O2
SMILES:
CC1=C(C=C(C=C1)N=C=O)N=C=O
InChI:
InChI=1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
10
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye damage.

Breakdown of all 1208 C&L notifications submitted to ECHA

Carc. 2 H351 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Aquatic Chronic 3 H412 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
Acute Tox. 1 H330
Acute Tox. 2 H330 Harmonised Classification
Eye Dam. 1 H318
STOT SE 3 H336
Eye Irrit. 2A H319
STOT RE 1 H372
STOT SE 2 H371
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 10 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of chemicals at non-dedicated facilities, roller or brushing applications, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, laboratory work, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, for thermoplastic manufacture and in the production of articles.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, transfer of chemicals at dedicated facilities, laboratory work, mixing in open batch processes, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, for thermoplastic manufacture, formulation in materials and in the production of articles.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals at dedicated facilities and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and for thermoplastic manufacture.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; wear respiratory protection.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention.

Storage statements

Store this substance in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • AFCONA Additives B.V., Amperestraat 34 1704SN Heerhugowaard Netherlands
  • BorsodChem, Bolyai ter 1 3700 Kazincbarcika Hungary
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • BYK Chemie GmbH - OR, Abelstrasse 45 46483 Wesel Germany
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Umax Chemicals (Shandong) Corporation.), Regus Harcourt Centre D02 Dublin Ireland
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR US_001257, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • EXTRACTHIVE CHEMICAL PRODUCTS, CS 10017 - Rue Lavoisier 38801 LE PONT DE CLAIX Cedex France
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Arcerion GmbH, Gabrielenstr. 15 80636 Muenchen Germany

Substance names and other identifiers

2,4-toluene diisocyanate
EU. Com. Reg. No 10/2011 on plastic materials in contact with food
4-methyl-m-phenylene diisocyanate
EC Inventory, C&L Inventory, REACH pre-registration, EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels
4-methyl-m-phenylene diisocyanate; toluene-2,6-di-isocyanate
EU. Worker Protection-Hazardous (98/24), EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
Toluene 2,4-diisocyanate
Other
toluene-2,6-di-isocyanate
C&L Inventory, EU. Dangerous Substances - Eco-Labels
2,6-diisocianato de tolueno (es)
C&L Inventory
2,6-diisocianato de toluileno (pt)
C&L Inventory
2,6-Diisocyanat-toluol (de)
C&L Inventory
2,6-diisocyanate de toluylène (fr)
C&L Inventory
2,6-diisocyanatotoluen (da)
C&L Inventory
2,6-diizocianatotoluen (sl)
C&L Inventory
2,6-TDI (fr)
C&L Inventory
2,6-toluen-diisocianato (it)
C&L Inventory
4-methyl-m-fenyleendiisocyanaat (nl)
C&L Inventory
4-methyl-m-fenylen-diisokyanát (cs)
C&L Inventory
4-methyl-m-phenylendiisocyanat (da)
C&L Inventory
4-metil-m-fenilen diizocianat (hr)
C&L Inventory
4-metil-m-fenilendiizocianatas (lt)
C&L Inventory
4-metil-m-fenilén-diizocianát (hu)
C&L Inventory
4-metil-m-fenilēndiizocianāts (lv)
C&L Inventory
4-metyl-1,3-fenyléndiizokyanát (sk)
C&L Inventory
4-metyl-m-fenyldiisocyanat (sv)
C&L Inventory
4-metyl-m-fenylendiisocyanat (no)
C&L Inventory
4-metyyli-m-fenyleenidi-isosyanaatti (fi)
C&L Inventory
4-metüül-m-fenüleendiisotsüanaat (et)
C&L Inventory
4-мeтил-m-фенилен диизоцианат (bg)
C&L Inventory
diisocianato de 4-metil-m-fenileno (es)
C&L Inventory
diisocianato di 4-metil-m-fenilene (it)
C&L Inventory
diisocyanate de 4-méthyl-m-phénylène (fr)
C&L Inventory
diizocyjanian 4-metylo-m-fenylenu (pl)
C&L Inventory
diizocyjanian tolueno-2,4-diylu (pl)
C&L Inventory
tolueen-2,6-diisocyanaat (nl)
C&L Inventory
tolueen-2,6-diisotsüanaat (et)
C&L Inventory
tolueeni-2,6-di-isosyanaatti (fi)
C&L Inventory
toluen-2,4-diisocyanat (no)
C&L Inventory
toluen-2,6-di-isokyanát (cs)
C&L Inventory
toluen-2,6-di-izocianat (hr)
C&L Inventory
toluen-2,6-diisocyanat (sv)
C&L Inventory
toluen-2,6-diizocianatas (lt)
C&L Inventory
toluol-2,4-diizocianāts (lv)
C&L Inventory
toluol-2,6-diizocianát (hu)
C&L Inventory
toluén-2,6-diizokyanát (sk)
C&L Inventory
διϊσοκυανικό 4-μεθυλο-μ-φαινυλένιο 2,6-διϊσοκυανικό τολουόλιο (el)
C&L Inventory
толуен-2,6-ди-изоцианат (bg)
C&L Inventory
Benzene, 2,4-diisocyanato-1-methyl-
Other
1,3-diisocyanato-4-methylbenzene
Registration dossier
2,4-diisocyanate-1-methyl-benzene
C&L Inventory
2,4-diisocyanato-1-methyl-benzene
C&L Inventory
2,4-Diisocyanato-1-methylbenzene
C&L Inventory, Registration dossier, Other
2,4-toluene-diisocyanate
Registration dossier
4-Methyl-m-phenylendiisocyanat;2,6-Diisocyanat-toluol
C&L Inventory
4-methyl-m-phenylene diisocyanate toluene-2,6-di-isocyanate
C&L Inventory
4-methyl-m-phenylene diisocyanate;
C&L Inventory
methyl-m-phenylene diisocyanate
C&L Inventory
Reaction mass of 2-methyl-m-phenylene diisocyanate and Tolylene-2,4-diisocyanate
C&L Inventory
TOLUENE-2,4-DI-ISOCYANATE
C&L Inventory
Tolylene 2,4-Diisocyanate
C&L Inventory
Scuranate® T100
Registration dossier
Scuranate® TX
Registration dossier
1260158-01-7
CAS number
Other
1358624-38-0
CAS number
Other
584-84-9
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels, EU. Com. Reg. No 10/2011 on plastic materials in contact with food, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
59539-76-3
CAS number
Other
615-006-00-4
Index number
C&L Inventory
856307-56-7
CAS number
Other
86-91-9
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Not specified (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
21 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
21 °C

Boiling point

Study results
  • 1 study submitted
  • 1 study processed
R Boiling point
252 - 254 °C @ 101.1 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1.21 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 5 studies submitted
  • 3 studies processed
R Vapour pressure
1.4 - 2.1 Pa @ 20 °C [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Log Pow
3.43 @ 22 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
3.43 @ 22 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
124 mg/L @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
124 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
131 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
131 °C

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
41.04 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
48 h

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
24 h @ 26.85 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
180

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 12.5 µg/L (1)
Intermittent releases (freshwater) 125 µg/L (1)
Marine water 1.25 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1 mg/L (1)
Sediment (freshwater) No exposure of sediment expected (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 1 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 133 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
133 mg/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (48 h) 12.5 mg/L [1]
EC0 (48 h) 1.6 mg/L [1]
EC100 (48 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
12.5 mg/L
EC50 / LC50 for marine invertebrates
18.3 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 1.1 mg/L [1]
LOEC (21 days) 2.2 mg/L [1]
EC50 (21 days) 2 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 3.23 - 4.3 g/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
4.3 g/L
EC50 for marine water algae
3.23 g/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 100 mg/L [1]
EC0 (3 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (14 days) 1 g/kg soil dw [2]
LC50 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (17 days) 1 g/kg soil dw [2]
NOEC (14 days) 1 g/kg soil dw [4]
EC50 (14 days) 1 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (Other toxicological threshold) 35 µg/m³ irritation (respiratory tract)
Acute /short term: (Other toxicological threshold) 140 µg/m³ irritation (respiratory tract)
Local Effects
Long-term: (Other toxicological threshold) 35 µg/m³ irritation (respiratory tract)
Acute /short term: (Other toxicological threshold) 140 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
EYE Exposure
Hazard unknown (no further information necessary as no exposure expected)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 2 studies processed
P/RResults
LD50 4 130 - 5 110 mg/kg bw (rat) [2]
LD50 4 130 - 5 620 mg/kg bw (mouse) [2]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (60 min) 66 ppm (rat) [1]
M/CInterpretations of results
Toxicity Category I [1]

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 9 400 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 0.05 ppm [2]
NOAEC (mouse): 0.05 ppm [1]
LOAEC (rat): 0.05 - 0.15 ppm [2]
LOAEC (mouse): 0.05 ppm [1]

Study data: inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: in vivo
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant