Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
219-348-1
CAS no.:
2421-28-5
Index number:
607-100-00-9
Molecular formula:
C17H6O7
SMILES:
O=C(C1=CC2=C(C=C1)C(=O)OC2=O)C1=CC2=C(C=C1)C(=O)OC2=O
InChI:
InChI=1S/C17H6O7/c18-13(7-1-3-9-11(5-7)16(21)23-14(9)19)8-2-4-10-12(6-8)17(22)24-15(10)20/h1-6H
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
3
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful to aquatic life with long lasting effects and may cause an allergic skin reaction.

Breakdown of all 318 C&L notifications submitted to ECHA

Eye Irrit. 2 H319 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Aquatic Chronic 3 H412
Skin Sens. 1 H317
Skin Sens. 1A H317
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (33.33% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 2 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.

This substance is used by professional workers (widespread uses), at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of chemicals at dedicated facilities and non-industrial spraying.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • CABB Oy (OR of Jayhawk Fine Chemicals Corporation), Kemirantie 1 67900 Kokkola Finland

Substance names and other identifiers

1,3-Isobenzofurandione, 5,5'-carbonylbis-
Other
3,3',4,4'-Benzophenonetetracarboxylic acid dianhydride
Other
3,3',4,4'-Benzophenonetetracarboxylic dianhydride
Other
3,3',4,4'-Tetracarboxybenzophenone dianhydride
Other
4,4'-Carbonylbis(phthalic anhydride)
Other
4,4'-carbonyldi(phthalic anhydride)
C&L Inventory
4,4'-Carbonyldiphthalic anhydride
Other
4,4'-Diphthalic anhydride ketone
Other
benzophenone-3,3',4,4'-tetracarboxylic dianhydride
C&L Inventory
benzophenone-3,3',4,4'-tetracarboxylic dianhydride; 4,4'-carbonyldi(phthalic anhydride)
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
EC Inventory, REACH pre-registration
Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
REACH pre-registration, Other
Benzophenonetetracarboxylic acid anhydride
Other
Benzophenonetetracarboxylic acid dianhydride
Other
Benzophenonetetracarboxylic anhydride
Other
Benzophenonetetracarboxylic dianhydride
Other
Phthalic anhydride, 4,4'-carbonyldi- (8CI)
Other
3,3',4,4'-benzofenontetracarbonzuurdianhydride (nl)
C&L Inventory
3,3',4,4'-benzofenontetrakarboksylsyredianhydrid (no)
C&L Inventory
3,3',4,4'-benzofenontetrakarboxylsyradianhydrid (sv)
C&L Inventory
3,3',4,4'-Benzophenontetracarbonsäuredianhydrid (de)
C&L Inventory
3,3',4,4'-benzophenontetracarboxylsyredianhydrid (da)
C&L Inventory
4,4'- карбонилди (фталов анхидрид) (bg)
C&L Inventory
4,4'-carbonildi(ftalic anhidrida) (ro)
C&L Inventory
4,4'-Carbonyldiphthalsäureanhydrid (de)
C&L Inventory
4,4'-karbonil-di(ftal-anhidrid) (hr)
C&L Inventory
4,4'-karbonildi(ftalskābes anhidrīds) (lv)
C&L Inventory
4,4'-karbonildiftalio rūgšties anhidridas (lt)
C&L Inventory
4,4'-karbonyldi(ftalanhydrid) (sk)
C&L Inventory
4,4'-karbonyldiftalsyraanhydrid (sv)
C&L Inventory
4,4´-karbonylbis(ftalanhydrid) (cs)
C&L Inventory
4,4’-karbonildi(ftálsav-anhidrid) (hu)
C&L Inventory
4,4’-karbonüüldi(ftaalanhüdriid) (et)
C&L Inventory
Bensofenoon-3,3',4,4'-tetrakarboksüülhappe dianhüdriid (et)
C&L Inventory
Bentsofenoni-3,3',4,4'-tetrakarboksyylihappodianhydridi (fi)
C&L Inventory
benzfenono-3,3',4,4'-tetrakarboksirūgšties dianhidridas, (lt)
C&L Inventory
benzofenon-3,3',4,4'-tetrakarbonildianhidrīds (lv)
C&L Inventory
benzofenon-3,3’,4,4’-tetrakarbonsav-dianhidrid (hu)
C&L Inventory
benzofenon-3,4,3´,4´-tetrakarboxdianhydrid (cs)
C&L Inventory
benzofenona-3,3',4,4'-tetracarboxilic dianhidrida (ro)
C&L Inventory
dianhidrid 3,3',4,4'-benzofenontetrakarboksilne kisline (sl)
C&L Inventory
dianhidrid 4,4'-karbonildiftalne kisline (sl)
C&L Inventory
dianhidrid benzofenon-3,3',4,4'-tetrakarboksilne kiseline (hr)
C&L Inventory
dianhydrid kyseliny benzofenón-3,3',4,4'-tetrakarboxylovej (sk)
C&L Inventory
dianhydride 4,4'-carbonyldiphtalique (fr)
C&L Inventory
dianhydride benzophénone-3,3',4,4'-tétracarboxylique; anhydride 4,4'-carbonyldi(phtalique) (fr)
C&L Inventory
dianhídrido 3,3',4,4'-benzofenonatetracarboxílico (es)
C&L Inventory
dianidride 3,3',4,4'-benzofenontetracarbossilica (it)
C&L Inventory
dianidrido 3,4,3',4'-benzofenonatetracarboxílico (pt)
C&L Inventory
dianidrido 4,4'-carbonildiftálico (pt)
C&L Inventory
dibezwodnik 4,4`-karbonylodiftalowy (pl)
C&L Inventory
dibezwodnik benzofenono-3,3`,4,4`-tetrakarboksylowy (pl)
C&L Inventory
διανυδρίτης του 3,4:3,4'-βενζοφαινοτετρακαρβοξυλικού οξέος (el)
C&L Inventory
διανυδρίτης του 4,4'-καρβονυλοδιφθαλικού οξέος (el)
C&L Inventory
бензофенон -3,3',4,4'- тетракарбоксилов дианхидрид (bg)
C&L Inventory
1,3-Isobenzofurandione, 5,5'-carbonylbis-
Other
3,3',4,4'-Benzophenonetetracarboxylic dianhydride
C&L Inventory
3,3',4,4'-Benzophenonetetracarboxylic dianhydride (BTDA)
Registration dossier
4,4'-carbonyldi(phthalic anhydride)
C&L Inventory
5,5'-carbonylbis(2-benzofuran-1,3-dione)
C&L Inventory, Registration dossier
5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dione
Other
5-(1,3-dioxo-2-benzofuran-5-carbonyl)-2-benzofuran-1,3-dione
C&L Inventory, Other
benzophenone-3,3' 4,4'-tetracarboxylic dianhydride
C&L Inventory
BENZOPHENONE-3,3',4,4'-TETRACARBOXYLIC DIANHYDRIDE
C&L Inventory
benzophenone-3,3':4,4'-tetracarboxylic dianhydrid
C&L Inventory
benzophenone-3,3':4,4'-tetracarboxylic dianhydride
C&L Inventory
Benzophenonetetra carboxilicdianhydride
C&L Inventory
BTDA
Registration dossier
101505-15-1
CAS number
Other
101505-15-1
Deleted CAS number
Other
1156492-00-0
CAS number
Other
1156492-00-0
Deleted CAS number
Other
1189096-76-1
CAS number
Other
1189096-76-1
Deleted CAS number
Other
160903-84-4
CAS number
Other
160903-84-4
Deleted CAS number
Other
163915-23-9
CAS number
Other
163915-23-9
Deleted CAS number
Other
174612-63-6
CAS number
Other
174612-63-6
Deleted CAS number
Other
2421-28-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
55206-66-1
CAS number
Other
55206-66-1
Deleted CAS number
Other
607-100-00-9
Index number
C&L Inventory
64308-15-2
CAS number
Other
64308-15-2
Deleted CAS number
Other
65929-27-3
CAS number
Other
65929-27-3
Deleted CAS number
Other
68593-66-8
CAS number
Other
68593-66-8
Deleted CAS number
Other
86442-22-0
CAS number
Other
86442-22-0
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 1 study processed
R Melting / freezing point
218.67 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
218.67 °C

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.545

Vapour pressure

Study results
  • 2 studies submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 1 study processed
R Log Pow
3.299 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
3.3 @ 25 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
13.84 mg/L @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
13.84 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
No (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
10 min @ 40 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
18.13 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 70 µg/L (1)
Intermittent releases (freshwater) 700 µg/L (1)
Marine water 7 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 40 mg/L (1)
Sediment (freshwater) 2.4 mg/kg sediment dw (1)
Sediment (marine water) 240 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 270 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (4 days) 5.592 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (48 h) 70.7 mg/L [1]
EC50 (24 h) 50 - 100 mg/L [1]
NOEC (48 h) 50 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (72 h) 51.9 - 68.6 mg/L [2]
NOEC (72 h) 25 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
68.6 mg/L
EC10 or NOEC for freshwater algae
25 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (3 h) 1 g/L [1]
NOEC (3 h) 320 mg/L [1]
EC10 (3 h) 418 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1 g/L
EC10 or NOEC for microorganisms
418 mg/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 600 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1.8 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 370 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1.1 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3 mg/kg bw/day repeated dose toxicity
Acute /short term: (No hazard identified) -
Local Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (High hazard (no threshold derived)) -
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 10 %
Dermal: 10 %
Inhalation: 10 %

Acute toxicity

Study results
oral
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 12 800 mg/kg bw (rat) [1]
M/CInterpretations of results
Study cannot be used for classification [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 1 study processed
P/RResults
LC0 (6 h) 4.44 mg/L air (rat) [1]
M/CInterpretations of results
Study cannot be used for classification [1]

inhalation
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD0 3 160 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Study cannot be used for classification [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 12 800 mg/kg bw
Inhalation route:
No adverse effect observed LC50 4.44 mg/L air
Dermal route:
No adverse effect observed LD50 3 160 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEL (rat): 300 mg/kg bw/day [1]
LOAEL (rat): 1 000 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 1 study processed
P/RResults
LOAEC (guinea pig): 136 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
Adverse effect observed LOAEC 135 mg/m³ (subacute, guinea pig)
Inhalation route - local effects:
Adverse effect observed NOAEC 55 mg/m³ (subacute, guinea pig)

Genetic toxicity

Study results
Study data: in vitro
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: developmental
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant