Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
221-221-0
CAS no.:
3033-77-0
Index number:
Molecular formula:
C6H14ClNO
SMILES:
[Cl-].C[N+](C)(C)CC1CO1
InChI:
InChI=1/C6H14NO.ClH/c1-7(2,3)4-6-5-8-6;/h6H,4-5H2,1-3H3;1H/q+1;/p-1
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
10
Of which contain:
2 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance may cause cancer, is harmful if swallowed, is harmful in contact with skin, causes serious eye damage, is suspected of causing genetic defects, is suspected of damaging fertility, may cause damage to organs through prolonged or repeated exposure, is harmful to aquatic life with long lasting effects and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is suspected of damaging fertility or the unborn child.

Breakdown of all 725 C&L notifications submitted to ECHA

Carc. 1B H350 Harmonised Classification
Acute Tox. 4 H302 Harmonised Classification
Acute Tox. 4 H312 Harmonised Classification
Eye Dam. 1 H318 Harmonised Classification
Muta. 2 H341 Harmonised Classification
Repr. 2 H361f Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Aquatic Chronic 3 H412 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (100% of REACH registrations).
  • M
Suspected to be Mutagenic (Harmonised C&L).
  • R
Suspected to be Toxic to Reproduction (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 16 active registrations under REACH, 1 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 - 10 tonnes per year.

This substance is used at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; obtain special instructions before use; do not eat, drink or smoke when using this product; use personal protective equipment as required.; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Follow specific measures (see label). If skin irritation occurs: follow instructions specified by manufacturer/supplier. If skin irritation or a rash occurs: get medical advice/attention. Get medical advice/attention if you feel unwell. If exposed or concerned: get medical advice/attention. Immediately call a poison center or doctor/physician. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Rinse the mouth. Get medical advice/attention. Follow specific treatment (see label). If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin: wash with soap and water.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • BASF Personal Care and Nutrition GmbH, Henkelstr. 67 40589 Düsseldorf Germany
  • Chemigate Oy, Simpsiöntie 682 62100 Lapua Finland
  • Dow Belgium B.V.B.A., Grotesteenweg 214 B-2600 Antwerpen (Berchem) Belgium Belgium
  • DOW BENELUX B.V. OR-4, Postbus 48 4530 AA Terneuzen Netherlands
  • KIST Europe, KIST Europe Campus E7.1 66123 Saarbrücken Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Europe Coordination Center BVBA 04, Chaussee De Wavre 1945 Brussels Belgium
  • Nouryon Surface Chemistry AB, Stenunge Allé S-44485 STENUNGSUND Sweden
  • Nouryon Surface Chemistry AB, Stenunge Allé 3 - S-44485 Stenungsund - Sweden
  • RHODIA OPERATIONS, 52 rue de la Haie Coq 93300 AUBERVILLIERS France
  • Ricardo-AEA, Shoreham Technical Centre Old Shoreham Road BN43 8FG Shoreham West Sussex United Kingdom
  • Sachem Europe BV, Van Voordenpark 15 5301 KP Zaltbommel Gelderland Netherlands
  • TIGI Haircare GmbH, Hertzstraße 6 71083 Herrenberg Germany
  • TÜV SÜD Industrie Service GmbH, IS-USR-MUC Westendstraße 199 80686 Munich Germany

Substance names and other identifiers

2,3-epoxypropyltrimethylammonium chloride
EC Inventory, REACH pre-registration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures
2,3-epoxypropyltrimethylammonium chloride ... %; glycidyl trimethylammonium chloride ... %
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
2,3-epoxypropyltrimethylammonium chloride ...%
C&L Inventory
2,3-epoxypropyltrimethylammonium chloride; glycidyl trimethylammonium chloride
Workplace Signs - minimum requirements & signs on containers and pipes, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes
2-Oxiranemethanaminium, N,N,N-trimethyl-, chloride (1:1)
Other
glycidyl trimethylammonium chloride
EU Ecolabels - Restrictions for Hazardous Substances/Mixtures
glycidyl trimethylammonium chloride ...%
C&L Inventory
(2,3-epoxypropyl)trimethylamonium- chlorid …% (cs)
C&L Inventory
(glycidyl)tri(metyl)amónium-chlorid ... % (sk)
C&L Inventory
2,3-epoksipropiltrimetilamonija hlorīds ...% (lv)
C&L Inventory
2,3-epoksipropiltrimetilamonijev klorid ... % (sl)
C&L Inventory
2,3-epoksipropiltrimetilamonijev klorid … % (hr)
C&L Inventory
2,3-epoksipropiltrimetilamonio chloridas ...% (lt)
C&L Inventory
2,3-epoksipropyylitrimetyyliammoniumkloridi …% (fi)
C&L Inventory
2,3-epoksypropyltrimetylammoniumklorid ... % (no)
C&L Inventory
2,3-epoksüpropüültrimetüülammooniumkloriid …% (et)
C&L Inventory
2,3-epoxipropiltrimetilammónium-klorid ...% (hu)
C&L Inventory
2,3-epoxipropyltrimetylammoniumklorid ...% (sv)
C&L Inventory
2,3-epoxypropyltrimethylammoniumchlorid ...% (da)
C&L Inventory
2,3-Epoxypropyltrimethylammoniumchlorid ... % (de)
C&L Inventory
2,3-epoxypropyltrimethylammoniumchloride ...% (nl)
C&L Inventory
2,3-епоксипропилтриметиламониев хлорид ...% (bg)
C&L Inventory
chlorek 2,3-epoksypropylotrimetyloamoniowy ...% (pl)
C&L Inventory
chlorek glicydylotrimetyloamoniowy ...% (pl)
C&L Inventory
chlorure de 2,3-époxypropyltriméthylammonium à....%; chlorure de glycidyle et de triméthylammonium à ....% (fr)
C&L Inventory
chlorure de glycidyl-triméthylammonium ...% (fr)
C&L Inventory
cloreto de 2,3-epoxipropiltrimetilamónio ... % (pt)
C&L Inventory
cloreto de glicidiltrimetilamónio a ... % (pt)
C&L Inventory
cloruro de 2,3-epoxipropiltrimetilamonio ... % (es)
C&L Inventory
cloruro de glicidiltrimetilamonio ...% (es)
C&L Inventory
cloruro di 2,3-epossipropiltrimetilammonio …% (it)
C&L Inventory
cloruro di glicidile trimetilammonio ...% (it)
C&L Inventory
clorură de 2,3-epoxipropiltrimetilamoniu ...% (ro)
C&L Inventory
clorură de glicidil trimetilamoniu ...% (ro)
C&L Inventory
glicidil trimetilamonijev klorid ... % (sl)
C&L Inventory
glicidil trimetilamonijev klorid … % (hr)
C&L Inventory
glicidil-trimetilammónium-klorid ...% (hu)
C&L Inventory
Glicidiltrimetilamonija hlorīds ...% (lv)
C&L Inventory
glicidiltrimetilamonio chloridas ...% (lt)
C&L Inventory
glycidyltrimethylammoniumchlorid ...% (da)
C&L Inventory
Glycidyltrimethylammoniumchlorid ... % (de)
C&L Inventory
glycidyltrimethylammoniumchloride ...% (nl)
C&L Inventory
glycidyltrimethylamoniumchlorid …% (cs)
C&L Inventory
glycidyltrimetylammoniumklorid ...% (no)
C&L Inventory
glysidyylitrimetyyliammoniumkloridi ...% (fi)
C&L Inventory
glütsidüültrimetüülammooniumkloriid ...% (et)
C&L Inventory
klorur tat-2,3-epossipropiltrimetilammonju ...% (mt)
C&L Inventory
klorur tat-trimetilammonju gliċidil ...% (mt)
C&L Inventory
trimetyl(oxiranylmetyl)amónium-chlorid ... % (sk)
C&L Inventory
χλωριούχο 2,3-εποξυπροπυλοτριμεθυλαμμώνιο ...%· (el)
C&L Inventory
χλωριούχο γλυκιδυλοτριμεθυλαμμώνιο ...% (el)
C&L Inventory
глицидил триметиламониев хлорид ...% (bg)
C&L Inventory
2,3-Epoxypropyltrimethylamminonium chloride
C&L Inventory
EPTAC
Registration dossier
Glycidyltrimethylammonium chloride
C&L Inventory
GMAC
Registration dossier
N,N,N-trimethyl(oxiran-2-yl)methanaminium chloride
Registration dossier
Quab 151
Registration dossier
trimethyl(oxiran-2-ylmethyl)azanium chloride
Registration dossier
trimethyl(oxiran-2-ylmethyl)azanium;chloride
Registration dossier, Other
trimethyl[(oxiran-2-yl)methyl]azanium chloride
Other
RAISACAT 151
Registration dossier
129829-22-7
CAS number
Other
3033-77-0
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
603-211-00-1
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [4]
C Form
Not specified (50%), Crystalline (50%) [4]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 10 studies submitted
  • 4 studies processed
R Melting / freezing point
118 - 126 °C [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
118 °C

Boiling point

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 10 studies submitted
  • 4 studies processed
R Relative density
1.178 - 1.18 @ 20 °C [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.178 - 1.18

Vapour pressure

Study results
  • 8 studies submitted
  • 4 studies processed
R Vapour pressure
0.001 Pa @ 22 °C [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 8 studies submitted
  • 4 studies processed
R Log Pow
-1.3 @ 25 °C and pH 4 - 9.01 [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 8 studies submitted
  • 4 studies processed
R Water solubility (mass/vol.)
852 g/L @ 20 °C and pH 11 - 11.6 [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Water solubility
852 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 4 studies submitted
  • 4 studies processed
R Surface tension
73 - 73.4 mN/m @ 1 g/L and 20 °C [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Surface tension at 20 °C
73 mN/m @ 1 000 mg/L

Flash point

Study results
  • 8 studies submitted
  • 2 studies processed
R Flash point
138 - 155 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
400 °C [2]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 8 studies submitted
  • 2 studies processed
C Interpretation of results
Highly flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Highly flammable (50%), Non flammable (50%)

Explosiveness

Study results
  • 4 studies submitted
  • 4 studies processed
C Interpretation of results
Non-explosive (100%) [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 2
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
5.9 months @ 12 °C

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 8 studies submitted
  • 3 studies processed
C Interpretation of results
Inherently biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study 1 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
53.8

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Data not provided by the registrant

Short–term toxicity to fish

Study results
  • 7 studies submitted
  • 5 studies processed
P/RResults
LC50 (4 days) 1.992 - 3.2 g/L [5]
LC50 (72 h) 2.114 g/L [1]
LC50 (48 h) 2.233 g/L [1]
LC50 (24 h) 2.532 g/L [1]
LC100 (4 days) 2.32 g/L [1]

Type of Study provided
Studies with data
Key study 1 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
1.992 g/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 5 studies processed
P/RResults
EC50 (48 h) 12.5 - 707 mg/L [5]
LC50 (48 h) 17.2 mg/L [1]
NOEC (48 h) 6.3 mg/L [3]

Type of Study provided
Studies with data
Key study 1 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
16.4 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
NOEC (21 days) 160 µg/L [3]
LOEC (21 days) 490 µg/L [3]
EC50 (21 days) 550 µg/L [3]

Type of Study provided
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
160 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 1 g/L [4]
NOEC (72 h) 580 mg/L [3]
EC10 (72 h) 625 - 814 mg/L [4]

Type of Study provided
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
1 g/L
EC10 or NOEC for freshwater algae
580 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (3 h) 2 g/L [3]
EC10 (3 h) 443 mg/L [3]

Type of Study provided
Studies with data
Key study 1 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
2 g/L
EC10 or NOEC for microorganisms
443 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Dermal: 0.685 %

Acute toxicity

Study results
oral
  • 12 studies submitted
  • 2 studies processed
P/RResults
LD50 1 088 mg/kg bw (rat) [2]
LD50 1.34 mL/kg bw (rat) [2]
M/CInterpretations of results
Toxicity Category IV [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 2 2
Data waiving
no waivers
inhalation
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other 2 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
dermal
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study 4
Weight of evidence
Other 2
Data waiving
no waivers
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other 1 2
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 3.16 mg/kg bw/day [1]
LOAEL (rat): 3.16 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 10
Weight of evidence
Other 6 2
Data waiving
no waivers
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: developmental
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant