Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
270-728-3
CAS no.:
68477-39-4
Index number:
649-409-00-1
Molecular formula:
C35H46
SMILES:
*.CCC1=CC=CC=C1.CC1=CC=CC=C1C.CCC1=CC=CC=C1C.C1CC2C3CC(C=C3)C2C1
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
11
Of which contain:
5 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may be fatal if swallowed and enters airways.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is fatal if inhaled, is very toxic to aquatic life with long lasting effects, causes damage to organs through prolonged or repeated exposure, is toxic in contact with skin, is toxic if swallowed, is very toxic to aquatic life, may cause genetic defects, may cause cancer, is suspected of damaging fertility or the unborn child, causes serious eye irritation, is a highly flammable liquid and vapour, is suspected of causing cancer, causes skin irritation, may cause respiratory irritation, may cause an allergic skin reaction and may cause drowsiness or dizziness.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects, is a flammable liquid and vapour, is harmful in contact with skin, is harmful if inhaled and may cause damage to organs through prolonged or repeated exposure.

Breakdown of all 126 C&L notifications submitted to ECHA

Asp. Tox. 1 H304 Harmonised Classification
Repr. 2 H361
Skin Irrit. 2 H315
Acute Tox. 4 H312
Flam. Liq. 3 H226
Acute Tox. 4 H332
STOT RE 2 H373
Aquatic Chronic 2 H411
Muta. 1B H340
Carc. 1A H350
Eye Irrit. 2 H319
STOT SE 3 H335
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
Acute Tox. 4 H302
https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (18.75% of REACH registrations).
  • M
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Mutagenic (18.75% of REACH registrations).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (31.25% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 5 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Other release to the environment of this substance is likely to occur from: outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release, in processing aids at industrial sites, for thermoplastic manufacture and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; obtain special instructions before use; do not eat, drink or smoke when using this product; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Wash contaminated clothing before reuse. Get medical advice/attention if you feel unwell. If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. Collect spillage. If swallowed: rinse mouth. Do not induce vomiting. If inhaled: call a poison center or doctor/physician if you feel unwell. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Rinse the mouth. Do not induce vomiting. If eye irritation persists get medical advice/attention. Follow specific treatment (see label). If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin: wash with soap and water.

Storage statements

Store this substance in a dry place; locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • COVANCE CLINICAL DEVELOPMENT SA 168, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Monpou, 5-5 Planta 28050 Madrid Spain
  • MOL Petrochemicals Private Company Limited by Shares, TVK-Ipartelep, TVK Központi Irodaház (136. sz. épület, hrsz: 2119/3) 3581 Tiszaujvaros Hungary
  • RSI ChemRep Europe Ltd (K003), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy

Substance names and other identifiers

[A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydro-carbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129 °C to 194 °C (264 °F to 382 °F).]
A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264°F to 382°F).
C&L Inventory
Cracked kerosine
A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264°F to 382°F).
C&L Inventory
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction
EC Inventory, REACH pre-registration, Other
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction
A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264°F to 382°F).
C&L Inventory, REACH pre-registration, Other
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction; Cracked kerosine [A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264 °F to 382 °F).]
A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264°F to 382°F).
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction; Cracked kerosine
A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264°F to 382°F).
EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Workplace Signs - minimum requirements & signs on containers and pipes
Distillates, petroleum, cracked stripped steam-cracked petroleum distillates, C8-10 fraction
A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264°F to 382°F).
Other
(Keerumise koostisega süsivesinike segu, mis saadakse krakkimisel eraldatud aurkrakitud destillaatide destillatsioonil. Koosneb süsivesinikest, mille süsiniku aatomite arv on valdavalt vahemikus C8–C10, ning keeb vahemikus ligikaudu 129°C kuni 194°C.) (et)
C&L Inventory
(Složeni sastav ugljikovodika dobivena destilacijom produkata krekiranog stripiranog parnog krekiranog destilata. Sadrži pretežno ugljikovodike koji imaju broj ugljikovih atoma pretežito u rasponu od C8 do C10 i vrelište u rasponu od 129 °C do 194 °C.) (hr)
C&L Inventory
[Gőzkrakkolás desztillátumának párlata. Főleg C8-C10 szénhidrogéneket tartalmaz. Forráspont tartomány: 129 C° - 194 C° (264 °F - 382 °F).] (hu)
C&L Inventory
[Kompleks blanding av hydrokarboner dannet ved destillering av krakkede, strippede og dampkrakkede destillater. Består av hydrokarboner, C8 til C10, med omtrentlig kokepunktsintervall fra 129 °C til 194 °C (264 °F til 382 °F).] (no)
C&L Inventory
[Komplekss ogļūdeņražu savienojums, ko iegūst, destilējot destilātus bez vieglajām frakcijām pēc tvaika krekinga. Tā tajā ir pārsvarā ogļūdeņraži, kuros oglekļa atomu skaits ir galvenokārt diapazonā no C8 līdz C10, un aptuvens tā viršanas temperatūras diapazons ir no 129 °C līdz 194 °C (līdz 264 °F līdz 382 °F).] (lv)
C&L Inventory
[Komplexe Kombination von Kohlenwasserstoffen, erhalten durch Destillation gekrackter gestrippter Dampf-gekrackter Destillate. Besteht aus Kohlenwasserstoffen mit Kohlenstoffzahlen im Bereich von C8 bis C10 und siedet im Bereich von etwa 129°C bis 194°C.] (de)
C&L Inventory
[Komplexná kombinácia uhľovodíkov získaná stripovaním krakovaných destilátov z parného krakovania. Pozostáva z uhľovodíkov s počtom atómov uhlíka prevažne v rozmedzí od C8 do C10. Má teplotu varu v rozmedzí približne od 129 °C do 194 °C.] (sk)
C&L Inventory
[O combinaţie complexă de hidrocarburi, obţinuta prin distilarea unui distilat cracat cu abur deposedat-distilatelor de cracare. Se compune din hidrocarburi cu număr de atomi de carbon de la C8 la C10 şi interval de fierbere aproximativ de la 129 ° C la 194 ° C (264 din 382 de).] (ro)
C&L Inventory
[Složitá směs uhlovodíků získaná destilací krakovaných stripovaných pyrolyzních produktů. Je složena převážně z uhlovodíků s počtem uhlíkových atomů převážně v rozmezí C8 až C10 s rozmezím teplot varu přibližně 129 °C až 194 °C.] (cs)
C&L Inventory
[sudėtingas angliavandenilių mišinys, gautas distiliuojant krekinguotus desorbuotus garų fazėje krekinguotus naftos distiliatus. Jį sudaro angliavandeniliai, kurių anglies atomų skaičius yra tarp C8 ir C10, verdantys apytiksliai tarp 129°C ir 194°C (264°F ir 382°F) temperatūroje.] (lt)
C&L Inventory
[Комплексна комбинация от въглеводороди, получена при дестилация на крекирани ( stripped) дестилати от разделителната колона от паров крекинг. Състои се преобладаващо от въглеводороди с брой на въглеродните атоми преобладаващо в интервала от C8 до C10 включително и с температура на кипене приблизително в интервала от 129°C до 194°C (264°F до 382°F).] (bg)
C&L Inventory
Che-rosene da cracking (it)
C&L Inventory
Combinación compleja de hidrocarburos obtenida por destilación de destilados craqueados, craqueados a vapor y rectificados. Compuesta de hidrocarburos con un número de carbonos dentro del intervalo de C8 a C10 y con un intervalo de ebullición aproximado de 129°C a 194°C. (es)
C&L Inventory
Combinaison complexe d'hydrocarbures obtenue par distillation de distillats ayant subi vapocraquage, rectification et craquage. Se compose d'hydrocarbures dont le nombre de carbones se situe dans la gamme C8-10 et dont le point d'ébullition est compris approximativement entre 129°C et 194°C. (fr)
C&L Inventory
Combinazione complessa di idrocarburi ottenuta per distillazione di distillati crackizzati con vapore sottoposti a stripping-cracking. AE costituita da idrocarburi con numero di atomi di carbonio nell'intervallo C8-C10 e punto di ebollizione nell'intervallo 129°C-194°C ca. (it)
C&L Inventory
destilados (petróleo), de destilados de cracking e de stripping do steam-cracking de petróleo, fracção C8-10 (pt)
C&L Inventory
destilados (petróleo), destilados craqueados y rectificados del petróleo craqueado a vapor, fracción de C8-10 (es)
C&L Inventory
destilati (nafta), krekirani in z vodno paro krekirani naftnidestilati brez lahkih frakcij, C8–10 frakcija (sl)
C&L Inventory
Destilati (nafta), krekirani stripirani parom krekirani naftni destilati, C8-10 frakcija (hr)
C&L Inventory
Destillaadid (nafta),aurkrakkimise produktid, C8-10 fraktsioon (et)
C&L Inventory
destillat (petroleum), krackade strippade ångkrackade petroleumdestillat, C8-10-fraktion (sv)
C&L Inventory
Destillate (Erdöl), gekrackte gestrippte Dampf-gekrackte Erdöldestillate, C8-10-Fraktion (de)
C&L Inventory
destillaten (aardolie), gekraakte gestripte stoomgekraakte aardoliedestillaten, C8-10-fractie (nl)
C&L Inventory
destillater (petroleum), krakkede strippede dampkrakkede petroleumsdestillater, C8-10-fraksjon (no)
C&L Inventory
destillater (råolie), krakkede strippede dampkrakkede råoliedestillater, C8-10-fraktion (da)
C&L Inventory
Destiláty (ropné), destiláty z kraku a stripování pyrolyzovaných ropných destilátů, frakce C8-10; (cs)
C&L Inventory
destiláty (ropné), frakcia C8-10, krakované, stripované, destiláty z parného krakovania ropy (sk)
C&L Inventory
Destylaty (ropa naftowa), rektyfikowane produkty z krakingu parowego, frakcja C8-10 (pl)
C&L Inventory
Distilate (petroliere), cracate deposedat distilate de petrol cracate cu abur, fracţia C8-10 (ro)
C&L Inventory
distiliatai (nafta), krekinguoti desorbuoti garų fazėje krekinguoti naftos distiliatai, C8-10 frakcija (lt)
C&L Inventory
distillati (petrolio), distillati di petrolio crackizzati con vapore sottoposti a stripping-cracking, frazione C8-10 (it)
C&L Inventory
Distillats (pétrole), distillats pétroliers, vapocraquage, rectification et craquage, fraction en C8-10;kérosène de craquage;[combinaison complexe d'hydrocarbures obtenue par distillation de distillats ayant subi vapocraquage, rectification et craquage. Se compose d'hydrocarbures comportant majoritaitement entre 8 et 10 atomes de carbone (C8-C10) et dont l'intervalle d'ébullition est compris approximativement entre 129 et 194 oC (entre 264 et 382 oF).] (fr)
C&L Inventory
Een complexe verzameling koolwaterstoffen, verkregen door het destilleren van gekraakte gestripte stoomgekraakte destillaten. Bestaat uit koolwaterstoffen, overwegend C8 tot en met C10, met een kooktraject van ongeveer 129°C tot 194°C. (nl)
C&L Inventory
En sammensat blanding af carbonhydrider opnået ved at destillere krakkede, strippede, dampkrakkede destillater. Den består af carbonhydrider, C8 til og med C10, med kogeinterval omtrent fra 129°C til 194°C. (da)
C&L Inventory
Frakcja naftowa z krakowania (pl)
C&L Inventory
Gekraakte kerosine (nl)
C&L Inventory
Kerosen obtinut prin cracare (ro)
C&L Inventory
Kompleksna kombinacija ogljikovodikov dobljena z destilacijokrekiranih in z vodno paro krekiranih destilatovbrez lahkih frakcij. Sestoji iz ogljikovodikov, ki imajoštevilo ogljikov v območju od C8 do C10 in vreliščev območju od približno 129° C do 194° C (264° F do382° F). (sl)
C&L Inventory
Krackkerosin (de)
C&L Inventory
Krakattu kerosiini (fi)
C&L Inventory
krakket parafin (no)
C&L Inventory
Krakket petroleum (da)
C&L Inventory
Krakkolt kerozin (hu)
C&L Inventory
Krakkpetrooleum (et)
C&L Inventory
krakovaný petrolej (sk)
C&L Inventory
Krakový petrolej (cs)
C&L Inventory
krekiran kerozin (sl)
C&L Inventory
Krekirani petrolej (hr)
C&L Inventory
Kérosène de craquage (fr)
C&L Inventory
naftas destilāti bez vieglajām frakcijām pēc tvaika krekinga, C8-10 frakcija (lv)
C&L Inventory
petrolejas krekinga products (lv)
C&L Inventory
Párlatok (ásványolaj), gőzzel krakkolt ásványolaj desztillátum C8-C10 frakció (hu)
C&L Inventory
Que-roseno craqueado (es)
C&L Inventory
Que-roseno de cracking (pt)
C&L Inventory
Tisleet (maaöljy), krakatut stripatut höyrykrakatut maaöljytisleet, C8-10-fraktio (fi)
C&L Inventory
Uma combinação complexa de hidrocarbonetos obtida por destilação de destilados de cracking e de stripping do steam-cracking. BE constituída por hidrocarbonetos com números de átomos de carbono na gama de C8 até C10 e destila no intervalo de aproximadamente 129°C a 194°C. (pt)
C&L Inventory
Złożona mieszanina węglowodorów otrzymywana przez rektyfikację destylatów z krakingu z parą wodną. Składa się z węglowodorów o liczbie atomów węgla w zakresie od C8 do C10. Wrze w zakresie temp. od ok. 129°Cdo194°C (pl)
C&L Inventory
žibalo krekingas (lt)
C&L Inventory
Ααπόσταγμα (πετρελαίου), πυρολυμένων απογυμνωμένων ατμοπυρολυμένων αποσταγμάτων πετρελαίου, κλάσμα C8-10 (el)
C&L Inventory
Κηεροζξίνη από διάσπαση (el)
C&L Inventory
Дестилати (нефт), нефтени дестилати от крекинг процес, от разделителна колона ( stripped) на паров крекинг, C8-10 фракция (bg)
C&L Inventory
Крекиран керосин (bg)
C&L Inventory
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction
Other
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction
C&L Inventory, Registration dossier
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction
Registration dossier
649-409-00-1
Index number
C&L Inventory
68477-39-4
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 27 studies submitted
  • 26 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [26]
C Form
Other (91%), Viscous (9%) [11]
C Odour
Characteristic of aromatic compounds (75%), Other (21%) [24]
C Substance type
Petroleum product (67%), Organic (33%) [24]

Type of Study provided
Studies with data
Key study 9 17
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 9 studies submitted
  • 8 studies processed
R Melting / freezing point
-100 - -29 °C @ 101.3 kPa [10]

Type of Study provided
Studies with data
Key study 8
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 6 summaries processed
Melting / freezing point at 101 325 Pa
-95.15 - 32.2 °C

Boiling point

Study results
  • 24 studies submitted
  • 16 studies processed
R Boiling point
54.3 - 265 °C @ 100.7 - 101.33 kPa [18]

Type of Study provided
Studies with data
Key study 12 5
Supporting study 1 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 6 summaries processed
Boiling point at 101 325 Pa
80.09 - 172.2 °C

Density

Study results
  • 15 studies submitted
  • 6 studies processed
R Relative density
0.83 - 0.89 @ 20 °C [6]

Type of Study provided
Studies with data
Key study 8
Supporting study 1 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 9 summaries submitted
  • 9 summaries processed
Relative density at 20°C
0.87 - 866

Vapour pressure

Study results
  • 32 studies submitted
  • 24 studies processed
R Vapour pressure
2.5 - 550 hPa @ 20 - 50 °C [34]

Type of Study provided
Studies with data
Key study 24
Supporting study 3 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 6 summaries processed
Vapour pressure
1.86 - 111.4 hPa @ 20 - 21.1 °C

Partition coefficient

Study results
  • 10 studies submitted
  • 8 studies processed
R Log Pow
2.2 - 6.5 @ -248.15 - 25 °C and pH 6.2 - 7 [8]

Type of Study provided
Studies with data
Key study 8
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 6 summaries processed
Log Kow (Log Pow)
2.13 - 6.5 @ 20 °C

Water solubility

Study results
  • 8 studies submitted
  • 7 studies processed
R Water solubility (mass/vol.)
25 - 600 mg/L @ 20 °C and pH 5.2 - 9.1 [6]
R Water solubility (vol%)
0.1 - 0.7 vol% @ 20 °C and pH 6.4 [2]

Type of Study provided
Studies with data
Key study 7
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 6 summaries processed
Water solubility
20 - 1 880 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 7
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
71.1 - 71.8 mN/m @ 243 - 244 mg/L

Flash point

Study results
  • 10 studies submitted
  • 10 studies processed
R Flash point
-30 - 107 °C @ 101.3 kPa [12]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
7.4 - 73 °C

Auto flammability

Study results
  • 7 studies submitted
  • 7 studies processed
R Autoflammability / self-ignition
401 - 502 °C @ 100.6 - 101.3 kPa [7]

Type of Study provided
Studies with data
Key study 7
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
421 - 429 °C

Flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 10 studies submitted
  • 8 studies processed
R dynamic viscosity (in mPa s)
0.45 - 0.95 [12]
R kinematic viscosity (in mm²/s)
0.54 - 1.9 [16]

Type of Study provided
Studies with data
Key study 8
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Static viscosity at 20 °C
3.25 mm²/s
Dynamic viscosity at 20 °C
0.723 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
Not readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (80%), Readily biodegradable (20%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
150.1 L/kg ww
Bioaccumulation Factor (BCF) - dimensionless
1 112

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
3.04

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No data available: testing technically not feasible (2)
Intermittent releases (freshwater) No data available: testing technically not feasible (2)
Marine water No data available: testing technically not feasible (2)
Intermittent releases (marine water) No data available: testing technically not feasible (2)
Sewage treatment plant (STP) No data available: testing technically not feasible (2)
Sediment (freshwater) No data available: testing technically not feasible (2)
Sediment (marine water) No data available: testing technically not feasible (2)
Hazard for Air
Air Hazard related to composition of atmosphere identified (2)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 1 mg/L [1]
LL50 (4 days) 1.1 mg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 1.2 - 2.7 mg/L [2]
LL50 (48 h) 1.99 mg/L [1]
EL50 (48 h) 1.2 - 3.3 mg/L [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (4 days) 910 - 1 800 µg/L [4]
EC50 (72 h) 1.3 - 2 mg/L [2]
NOEC (4 days) 120 µg/L [1]
EL50 (4 days) 1.2 - 2.2 mg/L [4]
EL50 (72 h) 790 - 2 300 µg/L [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
790 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for microorganisms
28.99 mg/L

Sediment toxicity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 6 summaries submitted
  • 6 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.31 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 384 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 2.31 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 160.23 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 950 µg/kg bw/day repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 690 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 226 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 690 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 143.5 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 280 µg/kg bw/day repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 30 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 25.6 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 5 1
Supporting study 12 4
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: dermal absorption
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 6 5
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 3.6 %
Inhalation: 50 %

Acute toxicity

Study results
oral
  • 13 studies submitted
  • 13 studies processed
P/RResults
LD50 512 - 6 631 mg/kg bw (rat) [15]
LD50 5 251 - 5 627 mg/kg bw (mouse) [4]
M/CInterpretations of results
Practically nontoxic [1]

Type of Study provided
oral
Studies with data
Key study 13
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 14 studies submitted
  • 14 studies processed
P/RResults
LC50 (6 h) 1.723 mg/L air (rat) [1]
LC50 (6 h) 284 - 353 ppm (rat) [2]
LC50 (4 h) 5.14 - 43.767 mg/L air (rat) [11]
LC50 (4 h) 5 922 - 13 700 ppm (rat) [11]
LC50 (6 h) 738.5 mg/m³ air (mouse) [1]
M/CInterpretations of results
Toxic [2]

inhalation
Studies with data
Key study 13 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 11 studies submitted
  • 11 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
LD50 2 000 - 12 126 mg/kg bw (rabbit) [7]
LD50 5 000 mL/kg bw (rabbit) [2]
M/CInterpretations of results
Practically nontoxic [2]

dermal
Studies with data
Key study 9
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Oral route:
Adverse effect observed LD50 590 mg/kg bw
Inhalation route:
Adverse effect observed LC50 1 972 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5 5
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 5 1
Supporting study
Weight of evidence 3 3
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 23 studies submitted
  • 14 studies processed
P/RResults
NOAEL (rat): 4 - 625 mg/kg bw/day [15]
NOAEL (mouse): 625 mg/kg bw/day [2]
LOAEL (rat): 25 - 1 250 mg/kg bw/day [6]
LOAEL (mouse): 1 250 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 12 2
Supporting study 3
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 21 studies submitted
  • 19 studies processed
P/RResults
NOAEC (rat): 96 - 2 355 mg/m³ air [5]
NOAEC (rat): 30 - 7 000 ppm [20]
NOAEC (mouse): 32 - 96 mg/m³ air [2]
NOAEC (mouse): 5 - 2 000 ppm [5]
LOAEC (rat): 2.261 - 4.71 mg/L air [4]

Study data: inhalation
Studies with data
Key study 17 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
M/C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 4 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 2 000 mg/kg bw/day (subacute, rabbit)
Dermal route - local effects:
Adverse effect observed LOAEL 200 mg/cm² (subacute, rabbit)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 1 131 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 1 131 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 34 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 28 4
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 10 7
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 6 summaries submitted
  • 4 summaries processed
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 11 5
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 6 summaries submitted
  • 3 summaries processed
Oral route:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, rat)
Inhalation route:
No adverse effect observed NOAEC 4 522 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 9 1
Supporting study 2
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 19 3
Supporting study
Weight of evidence 1
Other 8
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 6 summaries submitted
  • 2 summaries processed
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 60 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 7 5
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant