Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name:
  • IUPAC name: Essential oil of Lime obtained from the peel of Citrus aurantifolia, Rutaceae by expression and/or distillation, including cold-pressed, distilled, terpenes and essence qualities
  • Substance names and other identifiers
EC / List no.:
290-010-3
CAS no.:
90063-52-8
Index number:
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Other
Registered compositions:
39
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance may be fatal if swallowed and enters airways, is toxic to aquatic life with long lasting effects, is a flammable liquid and vapour, causes skin irritation and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is very toxic to aquatic life with long lasting effects and is very toxic to aquatic life.

Breakdown of all 1813 C&L notifications submitted to ECHA

Asp. Tox. 1 H304
Skin Irrit. 2 H315
Skin Sens. 1 H317
Flam. Liq. 3 H226
Aquatic Chronic 1 H410
Aquatic Acute 1 H400
Aquatic Chronic 2 H411
Eye Irrit. 2 H319
Acute Tox. 4 H302
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 28 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: air care products, cosmetics and personal care products, polishes and waxes, washing & cleaning products and biocides (e.g. disinfectants, pest control products).

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: polishes and waxes, washing & cleaning products and cosmetics and personal care products.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, closed, continuous processes with occasional controlled exposure, non-industrial spraying, treatment of articles by dipping and pouring, closed processes with no likelihood of exposure and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

This substance is used in the following products: perfumes and fragrances, air care products, biocides (e.g. disinfectants, pest control products), polishes and waxes and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: washing & cleaning products, biocides (e.g. disinfectants, pest control products) and metal surface treatment products.

This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, industrial spraying, roller or brushing applications, treatment of articles by dipping and pouring, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and in the production of articles.

This substance is used in the following activities or processes at workplace: batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals at dedicated facilities, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use explosion-proof equipment (electrical/ventilating/lighting/etc.); avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Do not induce vomiting.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ASTIER-DEMAREST S.A., 60, route de la Paoute 06130 GRASSE France
  • Blue Frog Scientific EURL, 967 Route de la Plaine La Plaine 26400 Chabrillan France
  • BONTOUX S.A.S., Le clôt 26170 Saint Auban sur l'Ouvèze France
  • Capua 1880 S.r.l., Zona Industriale 89052 Campo Calabro Reggio Calabria Italy
  • CILIONE S.r.l., via S. Antonio Arangea 89132 Reggio Calabria Italy
  • CITROFLOR S.R.L., Contrada Vivo snc 89030 Condofuri Marina RC-CALABRIA Italy
  • DALLANT, Carretera Laureà Miró 392 088980 ST.FELIU DE LLOBREGAT - BARCELONA Spain
  • Erich Ziegler GmbH, Am Weiher 133 91347 Aufsess Germany
  • ERNESTO VENTOS, S.A., Carretera Reial 120B 08960 Sant Just Desvern Spain
  • F.D.Copeland & Sons (Europe) Limited, 38 Upper Mount street D02 PR89 Dublin Ireland
  • FIRMENICH GRASSE SAS OR 1, Parc Industriel Les Bois de Grasse 06130 Grasse France
  • FIRMENICH GRASSE SAS OR 8, Parc Industriel Les Bois de Grasse 06130 Grasse France
  • Frey + Lau GmbH, Immenhacken 12 DE-24558 Henstedt-Ulzburg Germany
  • Givaudan France SAS - OR1, 55, Rue de la voie des Bans CS500024 95102 Argenteuil Cedex France
  • Givaudan France SAS - OR2, 55, Rue de la voie des Bans 95102 Argenteuil Cedex France
  • Givaudan France SAS - OR7, 55, Rue de la voie des Bans 95102 Argenteuil Cedex France
  • J C Buck Europe S.L.U. , Guillem de Muntanyans 139-149 08223 Terrassa Barcelona Spain
  • Johann Voegele KG, Bahnhofstrasse 143 74348 Lauffen Baden-Württemberg Germany
  • LLUCH ESSENCE, S.L.U., Lo Gaiter, 160 08820 EL PRAT DE LLOBREGAT CATALUÑA Spain
  • MCI Miritz Citrus GmbH & Co. KG, Citrusstraße 3 37318 Kirchgandern Germany
  • Misitano & Stracuzzi S.p.A., Via Ghibellina, 64 98122 Messina Italy
  • PRODARESS, P.A. du Pilon, Lot N° 3 06460 SAINT VALLIER DE THIEY France
  • Ramboll Belgium bvba, 46 Meersbloem-Melden 9700 Oudenaarde Belgium
  • Robertet, 37 Avenue Sidi Brahim 06130 Grasse France
  • Sintropia, S.L.U, C/ De Xaloc, 1 1º 4ª Edificio CNV- Polígono Industrial Can Volard 08150 Parets del Vallès Barcelona Spain
  • ULTRA INTERNATIONAL B.V., Malledijk 3H, 3208 LA Spijkenisse, (Loods 12-15) NETHERLANDS Netherlands
  • Univar Solutions B.V., Schouwburgplein 30-34 NL-3012 CL Rotterdam Netherlands
  • Yordas GmbH, Äußere Nürnberger Str. 6 91301 Forchheim Germany

Substance names and other identifiers

Lime (Citrus aurantifolia), ext.
EC Inventory
Lime (Citrus aurantifolia), ext.
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus aurantifolia, Rutaceae.
REACH pre-registration
Citrus aurantiifolia, ext.
Other
Citrus aurantifolia
C&L Inventory
Citrus aurantifolia ext.
Registration dossier
Essential oil extract of Citrus aurantifolia (Rutaceae) peel
C&L Inventory
Essential oil of Lime obtained from the peel of Citrus aurantifolia, Rutaceae by expression and/or distillation, including cold-pressed, distilled, terpenes and essence qualities
Registration dossier
Essential oil of Lime obtained from the peel of Citrus aurantifolia, Rutaceae by expression and/or distillation, including cold-pressed, distilled, terpenes and essence qualities
Registration dossier
Essential oil of Lime obtained from the peel of Citrus aurantifolia, Rutaceae by expression and/or distillation, including cold-pressed, distilled, terpenes and essence qualities.
Registration dossier
HE Citrus aurantifolia
C&L Inventory
Lime (Citrus aurantifolia) ext.
C&L Inventory
Lime (Citrus aurantifolia), essential oil
C&L Inventory
Lime (Citrus aurantifolia), ext
C&L Inventory, Registration dossier
Lime (Citrus aurantifolia), ext.
C&L Inventory, Registration dossier
Lime (Citrus aurantifolia), ext.
Registration dossier
Lime essential oil
C&L Inventory
Lime Oil
C&L Inventory, Registration dossier
Lime Oil
Registration dossier
Lime oil, extracts
C&L Inventory
Lime oil. Essential oil of Lime obtained from the peel of Citrus aurantifolia, Rutaceae by expression and/or distillation, including cold-pressed, distilled, terpenes and essence qualities
Registration dossier
Lime, essential oil
C&L Inventory
Cold Pressed Lime Oil Type A
Registration dossier
Cold Pressed Lime Oil Type B
Registration dossier
Cold Pressed Lime Oil Type B 4X
Registration dossier
Distilled Lime Oil
Registration dossier
Distilled Lime Oil 4X
Registration dossier
Heavy Oxygenated Fraction of Essential Lime Oil
Registration dossier
Key Lime Oil
Registration dossier
Lime distilled
Registration dossier
Lime Distilled Terpenes Topnote
Registration dossier
LIME DM
Registration dossier
LIME EO
Registration dossier
Lime Essence Oil
Registration dossier
Lime Expressed Residue
Registration dossier
LIME FOLD
Registration dossier
Lime Furocoumarinefree
Registration dossier
LIME OIL
Registration dossier
Lime Oil Citrus aurantifolia
C&L Inventory
Lime Oil Cold Pressed
Registration dossier
Lime Oil Cold Pressed 1-Fold
Registration dossier
Lime Oil Cold Pressed Type A
Registration dossier
Lime Oil Cold Pressed Type B
Registration dossier
Lime Oil Cold Pressed X-Fold
Registration dossier
Lime Oil Cold Pressed X-Fold (X = Folding Factor)
Registration dossier
Lime Oil Cold Pressed, Lime Oil Distilled, Lime Oil Lime Oil Dist folded, Lime Oil CP folded, Lime Terpenes Cold Pressed, Lime Terpenes Distilled, Lime Essence Oil, Lime Essence Oil folded, LimeFraction, Lime Oil CLK, Lime Oil terpenfree, Lime Oil terpenless, Lime Oil Tahiti, Lime Oil Key A,Lime Oil Key B, Lime Oil Tahiti terpenless, Lime Oil CLC
Registration dossier
Lime Oil Concentrate
Registration dossier
Lime oil Decolorized
Registration dossier
Lime Oil Distilled
Registration dossier
Lime Oil Distilled 1-Fold
Registration dossier
Lime Oil Distilled Terpenes
Registration dossier
Lime Oil Distilled West Indian
Registration dossier
Lime oil distilled X-Fold
Registration dossier
Lime Oil Distilled X-Fold (X = Folding Factor)
Registration dossier
Lime Oil Expressed
Registration dossier
Lime Oil Expressed Terpenes
Registration dossier
Lime oil Folded
Registration dossier
Lime Oil Mex. Dest.
Registration dossier
Lime Oil Terpenes
Registration dossier
Lime Oil Washed
Registration dossier
Lime Terpenes
Registration dossier
MID Oxygenated Fraction of Distilled Lime Oil
Registration dossier
Oxygenated Fraction of Distilled Lime Oil
Registration dossier
Persian Lime Oil
Registration dossier
Sri Lanka Organic Lime Oil (Distilled).
C&L Inventory
Tahiti Lime Oil
Registration dossier
Taiti Lime Oil
Registration dossier
68917-71-5
CAS number
C&L Inventory
8008-26-2
CAS number
C&L Inventory
84696-34-4
Deleted CAS number
Other
84929-37-3
Deleted CAS number
Other
90063-52-8
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Other (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Natural substance (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
-25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 2 studies submitted
  • 1 study processed
R Boiling point
130 °C @ 103 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
130 °C

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Density
0.862 g/cm³ @ 20 °C [1]
R Relative density
0.864 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.864

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
1.709 hPa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
1.709 hPa @ 25 °C

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Log Pow
3.33 - 7.12 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
4.38

Water solubility

Study results
  • 1 study submitted
  • 1 study processed
R Water solubility (mass/vol.)
70 - 1 767 000 µg/L @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
53.4 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
53.4 °C

Auto flammability

Study results
  • 1 study submitted
  • 1 study processed
R Autoflammability / self-ignition
240 °C @ 101.56 - 102 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
240 °C

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
1.33 [1]
R kinematic viscosity (in mm²/s)
1.54 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
1.33 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 5.4 µg/L (1)
Intermittent releases (freshwater) 5.77 µg/L (1)
Marine water 540 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 2.1 mg/L (1)
Sediment (freshwater) 1.3 mg/kg sediment dw (1)
Sediment (marine water) 130 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 290 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 44.44 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LL50 (4 days) 18 mg/L [1]
EL0 (4 days) 18 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EL50 (48 h) 5 mg/L [1]
EL50 (24 h) 15 mg/L [1]
NOELR (48 h) 2.2 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EL10 (72 h) 5.1 mg/L [1]
EL50 (72 h) 8 mg/L [1]
NOELR (72 h) 3.2 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
8 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 18.7 mg/m³ repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5.34 mg/kg bw/day repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: (DNEL) 185.8 µg/cm² sensitisation (skin)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.67 mg/m³ repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.66 mg/kg bw/day repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: (DNEL) 92.9 µg/cm² sensitisation (skin)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.66 mg/kg bw/day repeated dose toxicity
Acute /short term: - -
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 4 367 mg/kg bw (rat) [2]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 4 367 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Not classified [2]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 11 studies submitted
  • 6 studies processed
P/RResults
NOAEL (rat): 600 mg/kg bw/day [4]
NOAEL (mouse): 500 mg/kg bw/day [2]
NOAEL (dog): 100 mg/kg bw/day [2]
LOAEL (rat): 1 200 mg/kg bw/day [4]
LOAEL (mouse): 1 000 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 2 2
Weight of evidence 3 3
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2 1
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence 3 1
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant