Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
401-100-0
CAS no.:
109037-78-7
Index number:
015-142-00-9
Molecular formula:
C24H56O13P2Ti2
SMILES:
[Ti+4].[Ti+4].CC[O-].CC[O-].CC[O-].CCC[O-].CCC[O-].CCCCOP([O-])([O-])=O.CCCCOP([O-])(=O)OCCCC
InChI:
InChI=1S/C8H19O4P.C4H11O4P.2C3H7O.3C2H5O.2Ti/c1-3-5-7-11-13(9,10)12-8-6-4-2;1-2-3-4-8-9(5,6)7;2*1-2-3-4;3*1-2-3;;/h3-8H2,1-2H3,(H,9,10);2-4H2,1H3,(H2,5,6,7);2*2-3H2,1H3;3*2H2,1H3;;/q;;5*-1;2*+4/p-3
Type of substance:
UVCB
Origin:
Organic, Organometallic
Registered compositions:
6
Of which contain:
0 impurities relevant for classification
2 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is toxic to aquatic life with long lasting effects, is a highly flammable liquid and vapour and causes serious eye irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may cause drowsiness or dizziness.

Breakdown of all 109 C&L notifications submitted to ECHA

Aquatic Chronic 2 H411 Harmonised Classification
Flam. Liq. 2 H225 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
STOT SE 3 H336
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 5 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and in the production of articles.

This substance can be found in products with material based on: paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and plastic (e.g. food packaging and storage, toys, mobile phones).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following products: inks and toners.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and in the production of articles.

This substance is used in the following products: inks and toners.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: ground and bond container and receiving equipment; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use explosion-proof equipment (electrical/ventilating/lighting/etc.); use non-sparking tools; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Borica Europe BVBA, Elzenstraat 31 3950 Bocholt Belgium
  • Flint Group Italia S.p.A., Via Margherita de'Vizzi, 51/a 20092 Cinisello Balsamo (MI) Italy
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Johnson Matthey PLC, 5th Floor, 25 Farringdon Street EC4A 4AB London United Kingdom

Substance names and other identifiers

butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium (trialkyloxy)titanium phosphate
TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
C&L Inventory, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
EC Inventory, REACH pre-registration
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
REACH pre-registration, Other
Titanium, (butyl phosphate, ethyl alcohol, isopropyl alcohol) complexes
TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
Other
Titanium, Bu phosphate Et alc. iso-Pr alc. complexes
TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
Other
butil (dialkiloxi(dibutoxifosforiloxi))titaniu (trialkiloxi)titaniu fosfat (ro)
C&L Inventory
butil(dialkiloksi(dibutoksifosforiloksi)titan)fosfatas (lt)
C&L Inventory
butil(dialkiloksi(dibutoksifosforiloksi)titān) (trialkiloksititāna)fosfāts (lv)
C&L Inventory
butil(dialkiloksi)(dibutoksifosforiloksi)titanov fosfat (sl)
C&L Inventory
butil(dialkiloxi)dibutoxi-foszforiloxi-titán-tri(alkiloxi)-titán-foszfát (hu)
C&L Inventory
butil-(dialkil-oksi(dibutoksifosforil-oksi))titanijev (trialkil-oksi)titanijev fosfat (hr)
C&L Inventory
butyl(dialkyloxy(dibutoxyfosforyloxy)titaan)(trialkyloxytitaan)fosfaat (nl)
C&L Inventory
butyl(dialkyloxy(dibutoxyphosphoryloxy)titan)phosphat (da)
C&L Inventory
Butyl(dialkyloxy(dibutoxyphosphoryloxy)titan)phosphat (de)
C&L Inventory
butyl-[dialkyloxy(dibutoxyfosforyloxy)titánium]-(trialkyloxytitánium)-fosfát (sk)
C&L Inventory
butyl-{bis(alkyloxy)[(dibutoxyfosforyl)oxy]titanyl}-[tris(alkyloxy)titanyl]-fosfát (cs)
C&L Inventory
butyl[dialkyloksy(dibutoksyfosforyloksy)titan](trialkyloksytitan)fosfat (no)
C&L Inventory
butyl[dialkyloxi(dibutoxifosforyloxi)titan]trialkyloxititanfosfat (sv)
C&L Inventory
Butyyli(dialkyylioksi(dibutoksifosforyylioksi))titaani(trialkyylioksi)titaanifosfaatti (fi)
C&L Inventory
Butüül(dialkoksü(dibutoksüfosforüüloksü))titaan(trialküüloksü) titaanfosfaat (et)
C&L Inventory
fosfato de butilo, dialquiloxi(dibutoxifosforiloxi)titanio e trialquiloxititanio (pt)
C&L Inventory
fosfato de butilo, dialquiloxi(dibutoxifosforiloxi)titanio y trialquiloxititanio (es)
C&L Inventory
fosfato di butile, dialchilossi(dibutossifosforilossi)titanio e trialchilossititanio (it)
C&L Inventory
fosforan butylu-dialkoksy(dibutoksyfosforyloksy)tytanu(IV)-trialkoksytytanu(IV) (pl)
C&L Inventory
phosphate de butyle, de (dialkyloxy(dibutoxyphosphoryloxy))titane et de (trialkyloxy)titane (fr)
C&L Inventory
φωσφορικό βουτύλιο διαλκυλοξυ(διβουτοξυφωσφορυλοξυ)τιτάνιο τριαλκυλοξυτιτάνιο (el)
C&L Inventory
бутил (диалкилокси(дибутоксифосфорилокси))титанов) (триалкилокси)титанов фосфат (bg)
C&L Inventory
Titanium, Bu phosphate Et alc. iso-Pr alc. complexes
Other
butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
C&L Inventory, Registration dossier
Butyl [dialkoxy(dibutyl-phosphato)titanium] (trialkoxytitanium)phosphate
Registration dossier
Butyl(dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
Registration dossier
dititanium(4+) ion triethanolate bis(propan-1-olate) dibutyl phosphate butyl phosphate
Registration dossier
dititanium(4+) triethanolate bis(propan-1-olate) dibutyl phosphate butyl phosphate
Other
PRINTCAT 508
Registration dossier
PUREti Ti-C 30
Registration dossier
Reaction mass of 109037-78-7 and 64-17-5 and 67-63-0
C&L Inventory
Titanium, Bu phosphate Et alc. iso-Pr alc. complexes
Registration dossier
Tytan AP100
Registration dossier
Tytanium phosphate complex
C&L Inventory
INSOCAT 110
Registration dossier
PRINTCAT 508
Registration dossier
PUREti Ti-C 30
Registration dossier
PureTi-C 30
Registration dossier
TYTAN AP 100
Registration dossier
TYTAN CA 100
Registration dossier
TYTAN CX 35
Registration dossier
TYZOR IAM
Registration dossier
VERTEC IA10
Registration dossier
VERTEC IA11
Registration dossier
015-142-00-9
Index number
C&L Inventory
109037-78-7
CAS number
C&L Inventory, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 6 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [3]
C Form
Other (67%), Liquid (33%) [3]
C Odour
Other (100%) [2]
C Substance type
Organometallic (100%) [2]

Type of Study provided
Studies with data
Key study 3 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 2 studies processed
R Melting / freezing point
-80 - -13.4 °C @ 96.707 - 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-90 - -13.4 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
79.8 - 84 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Boiling point at 101 325 Pa
79.8 - 84 °C

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Density
0.99 - 1.1 g/cm³ @ 25 °C [1]
R Relative density
1 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
1 - 1.005

Vapour pressure

Study results
  • 5 studies submitted
  • 3 studies processed
R Vapour pressure
54.82 hPa @ 25 °C [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Vapour pressure
54.82 hPa @ 25 °C

Partition coefficient

Study results
  • 15 studies submitted
  • 2 studies processed
R Log Pow
-0.5 - 3.2 @ 23 °C and pH 2.7 - 2.8 [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 9
Other 2
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
0.25 - 3.2 @ 25 °C

Water solubility

Study results
  • 5 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
55.21 mg/L @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Water solubility
55.21 - 66 000 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 5 studies submitted
  • 3 studies processed
R Surface tension
49 mN/m @ 100 g/L and 20 °C [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Surface tension at 20 °C
49 mN/m @ 100 - 100 000 mg/L

Flash point

Study results
  • 7 studies submitted
  • 4 studies processed
R Flash point
12 - 15.6 °C @ 100 kPa [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
12 - 15.6 °C

Auto flammability

Study results
  • 5 studies submitted
  • 3 studies processed
R Autoflammability / self-ignition
386 °C @ 1.014 hPa [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
386 °C

Flammability

Study results
  • 6 studies submitted
  • 2 studies processed
C Interpretation of results
Highly flammable (100%) [2]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Highly flammable (50%), Flammable (50%)

Explosiveness

Study results
  • 5 studies submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Oxidising
Non oxidising (50%), No (50%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 4 studies submitted
  • 2 studies processed
R Other:
16 - 24 [1]
R dynamic viscosity (in mPa s)
23.56 - 37.44 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Static viscosity at 20 °C
22.22 mm²/s
Dynamic viscosity at 20 °C
23.56 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Half-life for hydrolysis
15 min @ 25 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 5 studies submitted
  • 3 studies processed
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 8 studies submitted
  • 1 study processed
R log Koc
9.386 dimensionless [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 2
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
9.4 - 2 434 000 000

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 4 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1.45 - 125 µg/L (4)
Intermittent releases (freshwater) 14.5 - 125 µg/L (4)
Marine water 145 - 1 250 ng/L (3)
Intermittent releases (marine water) 1.45 µg/L (2)
Sewage treatment plant (STP) 10 - 100 mg/L (2)
Sediment (freshwater) 57 - 353 000 000 µg/kg sediment dw (2)
Sediment (marine water) 5.7 - 35 300 000 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 3.8 - 70 600 000 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 26.67 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 10 mg/L [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
NOEC (14 days) 10 mg/L [2]
LC50 (21 days) 10 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 10 mg/L [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 3.2 mg/L [1]
LOEC (21 days) 10 mg/L [1]
EC50 (21 days) 45 - 100 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
EC50 (72 h) 1.45 mg/L [4]
NOEC (72 h) 125 µg/L [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for freshwater algae
1.45 mg/L
EC10 or NOEC for freshwater algae
125 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
IC50 (3 h) 1 g/L [2]
IC50 (30 min) 320 - 1 000 mg/L [2]
NOEC (3 h) 1 g/L [2]
NOEC (30 min) 320 mg/L [1]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
320 - 1 000 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 3
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.4 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 56.4 mg/m³ repeated dose toxicity
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 670 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 8 mg/kg bw/day -
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 987 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 2.32 mg/m³ -
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 667 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 670 µg/kg bw/day -
Local Effects
Long-term: DNEL
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 667 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 670 µg/kg bw/day -
EYE Exposure
High hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Absorption values
Oral: 30 %
Dermal: 30 %
Inhalation: 30 %

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 3 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [3]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 7 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 5.14 - 22.9 mg/L air (rat) [2]
M/CInterpretations of results
Other [2]

inhalation
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
dermal
  • 5 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [4]
M/CInterpretations of results
Practically nontoxic [1]

dermal
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 22.9 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 400 mg/kg bw/day [2]
NOEL (rat): 0 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study
Weight of evidence 1
Other 2
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
No adverse effect observed NOAEL 400 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 10
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence 1 1
Other 4
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 770 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant