Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
405-800-7
CAS no.:
27955-94-8
Index number:
604-048-00-9
Molecular formula:
C20H18O3
SMILES:
CC(C1=CC=C(O)C=C1)(C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
InChI:
InChI=1S/C20H18O3/c1-20(14-2-8-17(21)9-3-14,15-4-10-18(22)11-5-15)16-6-12-19(23)13-7-16/h2-13,21-23H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
9
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is toxic to aquatic life with long lasting effects.

Breakdown of all 94 C&L notifications submitted to ECHA

Aquatic Chronic 2 H411 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 3 active registrations under REACH, 2 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.

This substance is used at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and transfer of chemicals at dedicated facilities.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and transfer of chemicals at dedicated facilities.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment.

Response statements

In case of incident: Collect spillage.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • Only representative (No publishable name), null
  • SHPP B.V., Plasticslaan 1 4612PX Bergen op Zoom Netherlands
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority., null
  • Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority., null
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Henkel Nederland B.V., Brugwal 11 3432 NZ Nieuwegein Netherlands
  • Merck Performance Materials GmbH, Rheingaustrasse 190-196 65203 Wiesbaden Germany

Substance names and other identifiers

1,1,1-tris(4-hydroxyphenol)ethane
THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
1,1,1-Tris(4-hydroxyphenyl)ethane
THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
Other
4,4',4''-(ethan-1,1,1-triyl)triphenol
EC Inventory, C&L Inventory, REACH pre-registration, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
4,4',4''-(Ethan-1,1,1-triyl)triphenol
THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
C&L Inventory, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
4,4',4''-Ethylidynetrisphenol
THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
Other
Phenol, 4,4',4''-ethylidynetri- (8CI)
THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
Other
Phenol, 4,4',4''-ethylidynetris-
THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
Other
Tris(4-hydroxyphenyl)ethane
THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
Other
4,4',4"-(етан-1,1,1-триил)трифенол (bg)
C&L Inventory
4,4',4''-(etaan-1,1,1-triüül)trifenool (et)
C&L Inventory
4,4',4''-(etaani-1,1,1-triyyli)trifenoli (fi)
C&L Inventory
4,4',4''-(etan-1,1,1-triil)trifenol (hr)
C&L Inventory
4,4',4''-(etan-1,1,1-triil)trifenol (ro)
C&L Inventory
4,4',4''-(etan-1,1,1-triil)trifenol (sl)
C&L Inventory
4,4',4''-(etan-1,1,1-triil)trifenolis (lt)
C&L Inventory
4,4',4''-(etan-1,1,1-triil)trifenolo (it)
C&L Inventory
4,4',4''-(etan-1,1,1-triyl)trifenol (no)
C&L Inventory
4,4',4''-(etan-1,1,1-triyl)trifenol (sv)
C&L Inventory
4,4',4''-(etano-1,1,1-triil)trifenol (es)
C&L Inventory
4,4',4''-(etano-1,1,1-triil)trifenol (pt)
C&L Inventory
4,4',4''-(ethan-1,1,1-triyl)trifenol (cs)
C&L Inventory
4,4',4''-(ethan-1,1,1-triyl)trifenol (nl)
C&L Inventory
4,4',4''-(ethan-1,1,1-triyl)triphenol (da)
C&L Inventory
4,4',4''-(Ethan-1,1,1-triyl)triphenol (de)
C&L Inventory
4,4',4''-(etán-1,1,1-triyl)trifenol (sk)
C&L Inventory
4,4',4''-(etān-1,1,1-triil)trifenols (lv)
C&L Inventory
4,4',4''-(éthan-1,1,1-triyl)triphénol (fr)
C&L Inventory
4,4',4''-(αιθαν-1,1,1-τριϋλο)φαινόλ (el)
C&L Inventory
4,4`,4``-(etano-1,1,1-triylo)trifenol (pl)
C&L Inventory
4,4’,4”-etilidintrifenol (hu)
C&L Inventory
,4',4''-(ethan-1,1,1-triyl)triphenol
C&L Inventory
1,1,1-Tris(4-hydroxyphenyl)ethane
C&L Inventory, Registration dossier
4,4',4''-(ethan-1,1,1-triyl)triphenol
C&L Inventory, Registration dossier
4,4',4''-(ethan-1,1,1-triyl)triphenol
Registration dossier
4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol
C&L Inventory, Other
Phenol, 4,4',4''-ethylidynetris-
C&L Inventory
THPE
Registration dossier
ADDOLINK THPE
Registration dossier
THPE
Registration dossier
TRIS(PARA-HYDROXYPHENYL)ETHANE
Registration dossier
27955-94-8
CAS number
C&L Inventory, Registration dossier, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Waste Framework Directive, Annex III - Waste - Hazardous Properties
604-048-00-9
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 6 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Powder (100%) [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 5 studies submitted
  • 3 studies processed
R Melting / freezing point
244 - 248 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
246 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
470.92 °C @ 100 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
470.92 °C

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Relative density
1.23 @ 20 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
1.23

Vapour pressure

Study results
  • 5 studies submitted
  • 3 studies processed
R Vapour pressure
0 - 0.01 Pa @ 25 - 181 °C [5]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 3 studies processed
R Log Pow
3.88 @ 20 °C and pH 6.53 - 6.77 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
3.88 @ 20 °C

Water solubility

Study results
  • 5 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
25.1 mg/L @ 20 °C and pH 4.37 - 5.62 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Water solubility
25.1 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Solubility in mg/100g standard fat at 20 °C
241

Surface tension

Study results
  • 5 studies submitted
  • 3 studies processed
R Surface tension
71.6 mN/m @ 22.6 mg/L and 25 - 25.5 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 11 studies submitted
  • 5 studies processed
C Interpretation of results
Non flammable (60%), GHS criteria not met (40%) [5]

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 7 studies submitted
  • 2 studies processed
C Interpretation of results
Non-explosive (50%), GHS criteria not met (50%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 5 studies submitted
  • 1 study processed
C Interpretation of results
GHS criteria not met (100%) [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 5 studies submitted
  • 5 studies processed
C Dissociating properties
No (100%) [5]
R Dissociation constant
9 - 11.3 @ 25 °C [11]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 2 2
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
pKa at 20 °C
9.99 - 10

Viscosity

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 14 studies submitted
  • 5 studies processed
R BOD5
60 mg O2/g test material [1]
R COD
2.41 g O2/g test material [1]
C Interpretation of results
Not inherently biodegradable (75%), Not readily biodegradable (25%) [4]

Type of Study provided
Studies with data
Key study 7
Supporting study
Weight of evidence
Other 7
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Koc at 20°C
174

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 3.2 - 8.6 µg/L (3)
Intermittent releases (freshwater) 8.6 - 86 µg/L (3)
Marine water 320 ng/L (2)
Intermittent releases (marine water) No data: aquatic toxicity unlikely (1)
Sewage treatment plant (STP) 1.1 mg/L (2)
Sediment (freshwater) 67.2 µg/kg sediment dw (2)
Sediment (marine water) 6.7 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 11.5 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 3.3 - 3 300 000 mg/kg food (2)

Short–term toxicity to fish

Study results
  • 10 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 18.5 mg/L [3]
NOEC (4 days) 18.5 mg/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 9 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 18 mg/L [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 160 µg/L [2]
EC50 (21 days) 910 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 7 studies submitted
  • 3 studies processed
P/RResults
NOEC (72 h) 230 µg/L [4]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for freshwater algae
3.6 - 8.6 mg/L
EC10 or NOEC for freshwater algae
230 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 11 mg/L [2]
EC10 (3 h) 11 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
11 mg/L
EC10 or NOEC for microorganisms
11 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 391 µg/m³ -
Acute /short term: (DNEL) 35 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 1.2 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 35 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 110 µg/kg bw/day -
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 97 µg/m³ -
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 56 µg/kg bw/day -
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 7 studies submitted
  • 3 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [3]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
dermal
  • 7 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [3]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 9 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 100 - 1 000 mg/kg bw/day [3]
LOAEL (rat): 1 000 mg/kg bw/day [3]
NOEL (rat): 10 mg/kg bw/day [3]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Study data: inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 2
Other
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 2
Other
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed LOAEL 1 000 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 5 2
Supporting study 2
Weight of evidence
Other 8 9
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other 2 6
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 4
Other
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 3
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant