Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
411-290-7
CAS no.:
131538-00-6
Index number:
016-076-00-3
Molecular formula:
SMILES:
InChI:
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
3
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed and may cause damage to organs through prolonged or repeated exposure.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may cause damage to organs, is suspected of damaging fertility or the unborn child and may cause an allergic skin reaction.

Breakdown of all 4 C&L notifications submitted to ECHA

Aquatic Chronic 1 H410 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Acute Tox. 4 H302 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Repr. 2 H361
STOT SE 2 H371
Skin Sens. 1 H317
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (50% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 2 active registrations under REACH, 1 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 tonnes per annum.

This substance is used in articles, in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid.

This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following products: polymers.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers and laboratory chemicals.

This substance is used for the manufacture of: electrical, electronic and optical equipment and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, laboratory work and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; obtain special instructions before use; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. Collect spillage. Do not induce vomiting. If on skin: wash with soap and water.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • [Confidential], [Confidential]
  • Bruno Bock Chemische Fabrik GmbH & Co. KG, Eichholzer Straße 23 21436 Marschacht Lower Saxony Germany

Substance names and other identifiers

1-Propanethiol, 2,3-bis((2-mercaptoethyl)thio)-
Other
2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
EC Inventory, C&L Inventory, REACH pre-registration, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
2,3-Bis((2-mercaptoethyl)thio)-1-propanethiol
C&L Inventory, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
2,3-bis((2-mercapto-ethyl)thio)-1-propaanthiol (nl)
C&L Inventory
2,3-bis((2-mercapto-ethyl)thio)-1-propanthiol (da)
C&L Inventory
2,3-bis((2-mercapto-etil)tio)-1-propanotiol (es)
C&L Inventory
2,3-bis((2-mercapto-etil)tio)-1-propanotiol (pt)
C&L Inventory
2,3-bis((2-mercapto-etil)tio)-1-propantiolo (it)
C&L Inventory
2,3-bis((2-mercaptoetil)tio)-1-propan tiol (ro)
C&L Inventory
2,3-bis((2-mercaptoéthyl)thio)-1-propanethiol (fr)
C&L Inventory
2,3-bis((2-merkapto-etyl)tio)-1-propantiol (sv)
C&L Inventory
2,3-bis((2-Merkapto-etyyli)tio)-1-propaantioli (fi)
C&L Inventory
2,3-bis((2-merkaptoetil)tio)-1-propantiol (hr)
C&L Inventory
2,3-bis((2-merkaptoetil)tio)-1-propantiolis (lt)
C&L Inventory
2,3-bis((2-merkaptoetyl)tio)-1-propantiol (no)
C&L Inventory
2,3-bis((2-merkaptoetüül)tio)-1-propaantiool (et)
C&L Inventory
2,3-Bis(2-mercaptoethylsulfanyl)propan-1-thiol (de)
C&L Inventory
2,3-bis-((2-merkaptoetil)tio)-1-propāntiols (lv)
C&L Inventory
2,3-bis[(2-merkaptoetil)tio]propantiol (sl)
C&L Inventory
2,3-bis[(2-merkaptoetylo)tio]propano-1-tiol (pl)
C&L Inventory
2,3-bis[(2-sulfanylethyl)sulfanyl]propan-1-thiol (cs)
C&L Inventory
2,3-bis[(2-sulfanyletyl)sulfanyl]propán-1-tiol (sk)
C&L Inventory
2,3-bis[(2-sulfanyloetylo)sulfanylo]propano-1-tiol (pl)
C&L Inventory
2,3-bisz[(2-merkaptoetil)tio]-1-propántiol (hu)
C&L Inventory
2,3-δις((2-μερκαπτoαιθυλo)θειo)-1-πρoπανoθειόλη (el)
C&L Inventory
2,3-бис((2-меркаптоетил)тио)-1-пропантиол (bg)
C&L Inventory
1-Propanethiol, 2,3-bis[(2-mercaptoethyl)thio]-
Other
2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
C&L Inventory, Registration dossier
2,3-bis(2-sulfanylethylsulfanyl)propane-1-thiol
Other
2,3-bis[(2-sulfanylethyl)sulfanyl]propane-1-thiol
Other
GST
Registration dossier
THIOCURE DMPT
Registration dossier
2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
Registration dossier
THIOCURE DMPT
Registration dossier
016-076-00-3
Index number
C&L Inventory
131538-00-6
CAS number
C&L Inventory, Registration dossier, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
152048-82-3
CAS number
Other
152048-82-3
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 5 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]
C Form
Suspension (100%) [2]
C Odour
Characteristic of sulfur-containing compounds (100%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 5 studies submitted
  • 2 studies processed
R Melting / freezing point
-70 °C [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-70 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
300 °C [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
300 °C

Density

Study results
  • 5 studies submitted
  • 2 studies processed
R Relative density
1.258 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.26

Vapour pressure

Study results
  • 7 studies submitted
  • 2 studies processed
R Vapour pressure
56.2 Pa @ 20 °C [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
56.2 Pa @ 20 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 2 studies processed
R Log Pow
3.16 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
3.16 @ 25 °C

Water solubility

Study results
  • 5 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
12.1 mg/L @ 20 °C and pH 7 [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
12 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Solubility in mg/100g standard fat at 20 °C
13 190

Surface tension

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
70.5 mN/m

Flash point

Study results
  • 5 studies submitted
  • 2 studies processed
R Flash point
241 °C @ 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
241 °C

Auto flammability

Study results
  • 7 studies submitted
  • 4 studies processed
R Autoflammability / self-ignition
325 °C @ 99.2 - 101.5 kPa [4]

Type of Study provided
Studies with data
Key study 5
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
325 °C

Flammability

Study results
  • 8 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 3
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
43.2 min
Degradation rate constant with OH radicals
1.8 cm³ molecule-1 s-1

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life for hydrolysis
2.4 h @ 50 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 7 studies submitted
  • 2 studies processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 5 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - dimensionless
49

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
552.3

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 189 - 1 180 ng/L (3)
Intermittent releases (freshwater) 210 - 2 100 ng/L (3)
Marine water 18.9 - 118 ng/L (3)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 12.2 mg/L (1)
Sediment (freshwater) 11.1 - 69 µg/kg sediment dw (3)
Sediment (marine water) 1.11 - 6.9 µg/kg sediment dw (3)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil 2.11 - 13.3 µg/kg soil dw (3)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (3)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 210 µg/L [2]
NOEC (4 days) 80 µg/L [2]
LOEC (4 days) 160 µg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
LC50 (48 h) 220 µg/L [2]
LC50 (24 h) 470 µg/L [2]
EC0 (48 h) 62.5 µg/L [2]
EC0 (24 h) 62.5 µg/L [2]
NOEC (48 h) 31.25 µg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 32.1 - 101 µg/L [6]
EC10 (21 days) 59 - 69.6 µg/L [4]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 1.5 mg/L [2]
NOEC (72 h) 125 µg/L [2]
LOEC (72 h) 250 µg/L [2]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
1.5 mg/L
EC10 or NOEC for freshwater algae
125 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 235 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 333 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.76 mg/m³ effect on fertility
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 µg/kg bw/day effect on fertility
Acute /short term: No hazard identified
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 µg/kg bw/day effect on fertility
Acute /short term: (DNEL) 5 mg/kg bw/day acute toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 2 studies processed
P/RResults
LD50 3 428 - 3 643 mg/kg bw (rat) [6]
M/CInterpretations of results
Category 4 based on GHS criteria [2]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 9 studies submitted
  • 2 studies processed
M/CInterpretations of results
Category 3 based on GHS criteria [2]

inhalation
Studies with data
Key study 6
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [2]

dermal
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 3 577 mg/kg bw
Inhalation route:
No adverse effect observed LC50 5 000 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 50 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 50 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 10
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant