Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
444-860-9
CAS no.:
474510-57-1
Index number:
606-140-00-4
Molecular formula:
C21H24O4
SMILES:
CC(C)(O)C(=O)C1=CC=C(CC2=CC=C(C=C2)C(=O)C(C)(C)O)C=C1
InChI:
InChI=1S/C21H24O4/c1-20(2,24)18(22)16-9-5-14(6-10-16)13-15-7-11-17(12-8-15)19(23)21(3,4)25/h5-12,24-25H,13H2,1-4H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
3
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects and may cause damage to organs through prolonged or repeated exposure.

Breakdown of all 105 C&L notifications submitted to ECHA

Aquatic Acute 1 H400 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Registration:
This substance has 2 active registrations under REACH, 1 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 tonnes per annum.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: inks and toners.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, treatment of articles by dipping and pouring, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), mixing in open batch processes and roller or brushing applications.

Other release to the environment of this substance is likely to occur from: indoor use.

This substance is used in the following products: inks and toners.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: inks and toners.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, treatment of articles by dipping and pouring, roller or brushing applications, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: as processing aid and in the production of articles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • IGM Resins B.V., Gompenstraat 49 5145 RA Waalwijk Netherlands
  • IGM Resins Italia S.r.l, Via Vincenzo Monti, 8 20123 Milano Italy
  • Colors & Effects France S.A.S., Rue de la Chapelle 28 68330 Huningue France
  • IGM Resins Ltd, c/o Baldwins, Wynyard Park House Wynyard Avenue TS22 5TB Wynyard Durham United Kingdom
  • WSP UK Ltd., WSP HOUSE 70 CHANCERY LANE WC2A 1AF LONDON United Kingdom

Substance names and other identifiers

2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropion)benzyl)phenyl)-2-methylpropane-1-one
Other
2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)-2-methylpropan-1-one
C&L Inventory, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Bis(4-(2-hydroxy-2-methylpropionyl)phenyl)methane
Other
2,2'-dihydroxy-2,2'-dimetyl-1,1'-[metylénbis(4,1-fenylén)]di(propán-1-ón) (sk)
C&L Inventory
2-hidroksi-1-(4-(4-(2-hidroksi-2-metilpropionil)benzil)fenil)-2-metilpropan-1-on (hr)
C&L Inventory
2-hidroksi-1-(4-(4-(2-hidroksi-2-metilpropionil)benzil)fenil)-2-metilpropan-1-on (sl)
C&L Inventory
2-hidroksi-1-(4-(4-(2-hidroksi-2-metilpropionil)benzil)fenil)-2-metilpropan-1-onas (lt)
C&L Inventory
2-hidroksi-1-(4-(4-(2-hidroksi-2-metilpropionil)benzil)fenil)-2-metilpropan-1-ons (lv)
C&L Inventory
2-hidroxi-1-(4-(4-(2-hidroxi-2-metilpropionil)bencil)fenil)-2-metilpropan-1-ona (es)
C&L Inventory
2-hidroxi-1-(4-(4-(2-hidroxi-2-metilpropionil)benzil)fenil)-2-metil-propán-1-on (hu)
C&L Inventory
2-hidroxi-1-(4-(4-(2-hidroxi-2-metilpropionil)benzil)fenil)-2-metilpropan-1-ona (pt)
C&L Inventory
2-hidroxi-1-(4-(4-(2-hidroxi-2-metilpropionil)benzil)fenil)-2-metilpropan-1-onă (ro)
C&L Inventory
2-hydroksi-1-(4-(4-(2-hydroksi-2-metyylipropionyyli)bentsyyli)fenyyli)-2-metyylipropan-1-oni (fi)
C&L Inventory
2-hydroksy-1-(4-(4-(2-hydroksy-2-metylopropionylo)benzylo)fenylo)-2-metylopropan-1-on (pl)
C&L Inventory
2-hydroksy-1-(4-(4-(2-hydroksy-2-metylpropionyl)benzyl)fenyl)-2-metylpropan-1-on (no)
C&L Inventory
2-hydroxi-1-(4-(4-(2-hydroxi-2-metylpropionyl)benzyl)fenyl)-2-metylpropan-1-on (sv)
C&L Inventory
2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)fenyl)-2-methylpropaan-1-on (nl)
C&L Inventory
2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)-2-methylpropan-1-on (da)
C&L Inventory
2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)-2-methylpropan-1-on (de)
C&L Inventory
2-hydroxy-1-(4-(4-(2-hydroxy-2-méthylpropionyl)benzyl)phényl)-2-méthylpropan-1-one (fr)
C&L Inventory
2-hydroxy-1-{4-[4-(2-hydroxy- 2-methylpropanoyl)- benzyl]fenyl}-2-methylpropan- 1-on (cs)
C&L Inventory
2-hüdroksü-1-(4-(4-(2-hüdroksü-2-metüülpropionüül)bensüül)fenüül)-2-metüülpropaan-1-oon (et)
C&L Inventory
2-idrossi-1-(4-(4-(2-idrossi-2-metilpropionil)benzil)fenil)-2-metilpropan-1-one (it)
C&L Inventory
2-idrossi-1-(4-(4-(2-idrossi-2-metilpropjonil)benżil)fenil)-2-metilpropan-1-on (mt)
C&L Inventory
2-υδροξυ-1-(4-(4-(2-υδροξυ-2-μεθυλοπροπιονυλο)βενζυλο)φαινυλο)-2-μεθυλοπροπανόνη-1 (el)
C&L Inventory
2-хидрокси-1-(4-(4-(2-хидрокси-2-метилпропионил)бензил)фенил)-2-метилпропан-1-он (bg)
C&L Inventory
1-Propanone, 1,1'-(methylene-di-4,1-phenylene)bis[2-hydroxy-2-methyl-
Other
1-Propanone, 1,1'-(methylene-di-4,1-phenylene)bis[2-hydroxy-2-methyl-
C&L Inventory
2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl) benzyl) phenyl)-2-methylpropan-1-one
Registration dossier
2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl) benzyl) phenyl)-2-methylpropan-1-one
Registration dossier
2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)-2-methylpropan-1-one
C&L Inventory
2-hydroxy-1-(4-{[4-(2-hydroxy-2-methylpropanoyl)phenyl]methyl}phenyl)-2-methylpropan-1-one
C&L Inventory, Other
2-Hydroxy-1-[4-[[-(2-hydroxy-2-methylpropanoyl)phenyl]methyl]phenyl]-2-methylpropan-1-one
C&L Inventory
2-hydroxy-1-[4-[[4-(2-hydroxy-2-methylpropanoyl)phenyl]methyl]phenyl]-2-methylpropan-1-one
C&L Inventory, Other
2-idrossi-1-(4-(4-(2-idrossi-2metilpropionil)benzil)fenil)-2-metilpropan-1-one
C&L Inventory
1,1'-[Methylenebis(4,1-phenylene)]bis(2-hydroxy-2-methyl-1-propanone)
C&L Inventory
CGI 827
Registration dossier
Omnirad 127
Registration dossier
Photoinitiator 127
C&L Inventory
PI-127
C&L Inventory
1233234-05-3
Deleted CAS number
Other
474510-57-1
CAS number
C&L Inventory, Registration dossier, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
606-140-00-4
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [4]
C Form
Powder (100%) [4]
C Substance type
Organic (100%) [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 2 studies processed
R Melting / freezing point
84.3 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
84.3 °C

Boiling point

Study results
  • 2 studies submitted
  • 2 studies processed
R Boiling point
332.7 °C @ 97.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Boiling point at 101 325 Pa
332.7 °C

Density

Study results
  • 2 studies submitted
  • 2 studies processed
R Density
1.195 g/cm³ @ 19.7 °C [2]
R Relative density
1.195 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.195

Vapour pressure

Study results
  • 2 studies submitted
  • 2 studies processed
R Vapour pressure
0 - 0 Pa @ 50 - 60 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 2 studies processed
R Log Pow
2.3 @ 25 °C and pH 4.5 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
2.3 @ 25 °C

Water solubility

Study results
  • 2 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
9.9 mg/L @ 20 °C and pH 7.11 - 7.15 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
9.9 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Surface tension at 20 °C
67.3 mN/m

Flash point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 6 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
12.8 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life for hydrolysis
1 years @ 50 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 4 studies submitted
  • 2 studies processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
104

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
0.012 Pa m³/mol @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Henry's law constant
0.012 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 560 ng/L (2)
Intermittent releases (freshwater) 5.6 µg/L (2)
Marine water 56 ng/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (2)
Sediment (freshwater) 7.84 µg/kg sediment dw (2)
Sediment (marine water) 784 ng/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 1 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 3.5 - 6.8 mg/L [4]
LC0 (4 days) 2.7 - 4.6 mg/L [4]
NOEC (4 days) 2.7 - 4.6 mg/L [4]
LOEC (4 days) 4.6 - 10 mg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 560 - 680 µg/L [4]
EC0 (48 h) 420 - 460 µg/L [4]
EC100 (48 h) 760 - 1 000 µg/L [4]
NOEC (48 h) 420 - 460 µg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 3 - 100 mg/L [4]
NOEC (72 h) 530 - 1 000 µg/L [4]
LOEC (72 h) 1.5 - 3.2 mg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
3 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 100 mg/L [2]
NOEC (3 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for microorganisms
100 mg/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
LC10 (14 days) 1 g/kg soil dw [2]
LC50 (14 days) 1 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw
Long-term EC10 / LC10 / NOEC
1 g/kg soil dw

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 710 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 170 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 50 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 50 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Practically nontoxic [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Practically nontoxic [2]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 8 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 30 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 30 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 30 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 30 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant

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