Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
912-664-7
CAS no.:
-
Index number:
Molecular formula:
SMILES:
InChI:
Type of substance:
Multi constituent substance
Origin:
Inorganic
Registered compositions:
22
Of which contain:
26 impurities relevant for classification
0 additives relevant for classification
Substance Listed:

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance may cause cancer, may damage fertility or the unborn child, is very toxic to aquatic life with long lasting effects, is very toxic to aquatic life, is suspected of causing genetic defects, may cause damage to organs through prolonged or repeated exposure, causes serious eye irritation, may cause an allergic skin reaction and may cause allergy or asthma symptoms or breathing difficulties if inhaled.

Breakdown of all 8 C&L notifications submitted to ECHA

Carc. 1B H350
Muta. 2 H341
Skin Sens. 1 H317
STOT RE 2 H373
Resp. Sens. 1B H334
Repr. 1A H360
Repr. 1B H360
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
Eye Irrit. 2 H319
Aquatic Chronic 2 H411
Aquatic Chronic 4 H413
Resp. Sens. 1A H334
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (100% of REACH registrations).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (100% of REACH registrations).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 1 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.

This substance is used at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance and as an intermediate step in further manufacturing of another substance (use of intermediates).

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: obtain special instructions before use; in case of inadequate ventilation wear respiratory protection; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; avoid release to the environment; use personal protective equipment as required.; do not handle until all safety precautions have been read and understood; do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; avoid breathing the dust, fume, gas, mist, vapours or spray; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If eye irritation persists get medical advice/attention. Get medical advice/attention if you feel unwell. Wash contaminated clothing before reuse. If inhaled: if breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. If exposed or concerned: get medical advice/attention. If experiencing respiratory symptoms: call a poison center or doctor/physician. Collect spillage. If skin irritation or a rash occurs: get medical advice/attention. If on skin: wash with soap and water. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Follow specific treatment (see label).

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Glencore Nikkelverk AS, Vesterveien 31 4606 Kristiansand Norway
  • Glencore Import BV, Prinses Beatrixlaan 582 2595 BM Den Haag Netherlands
  • Glencore International Import BV, Prinses Beatrixlaan 582 2595 BM Den Haag Netherlands
  • Umicore Finland Oy, Kobolttiaukio 1 67900 KOKKOLA Finland
  • Umicore NV/SA, Rue du Marais 31 1000 Brussels Belgium

Substance names and other identifiers

Reaction mass of cobalt and copper and iron
REACH pre-registration
cobalt copper iron
Other
Reaction mass of cobalt and copper and iron
Registration dossier
white alloy
Registration dossier
White alloy (Reaction Mass of Co Cu Fe)
Registration dossier
White alloy (Reaction mass of cobalt and copper and iron)
Registration dossier
Alliage blanc
Registration dossier
Cobalt alloy
Registration dossier
White alloy
Registration dossier

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Compact (100%) [1]
C Substance type
Inorganic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
600 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Boiling point

Study results
  • 1 study submitted
  • 1 study processed
R Boiling point
600 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 8 studies submitted
  • 3 studies processed
R Density
8.78 - 8.86 g/cm³ @ 20 °C [2]
R Relative density
8.86 - 8.92 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1 2
Supporting study 3
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Vapour pressure

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 13 studies submitted
  • 10 studies processed
R Water solubility (mass/vol.)
100 - 192 030 000 ng/L @ 20 - 37 °C and pH 4.03 - 8.98 [59]

Type of Study provided
Studies with data
Key study 9
Supporting study 1 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 152 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 36
Supporting study 43 1
Weight of evidence 13 5
Other 1 52
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 30 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 6 2
Weight of evidence 7 3
Other 2 10
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 63 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 25 3 3
Weight of evidence 12 19
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Data not provided by the registrant

Short–term toxicity to fish

Study results
  • 85 studies submitted
  • 50 studies processed
P/RResults
LC50 (4 days) 2.8 - 85 300 µg/L [273]
NOEC (4 days) 656.8 - 53 900 µg/L [8]
LOEC (4 days) 1.43 - 88.7 mg/L [8]

Type of Study provided
Studies with data
Key study 6 1
Supporting study 19 2
Weight of evidence 8 36
Other 12
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 51 studies submitted
  • 25 studies processed
P/RResults
NOEC (11 months) 14.5 - 33 µg/L [3]
NOEC (10.9 months) 10.6 µg/L [3]
NOEC (9 months) 66 µg/L [1]
NOEC (8.133 months) 17.4 µg/L [3]
NOEC (6.3 months) 9.5 µg/L [2]

Type of Study provided
Studies with data
Key study 7
Supporting study 19 2
Weight of evidence 18
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 140 studies submitted
  • 53 studies processed
P/RResults
EC50 (4 days) 2.827 mg/L [1]
EC50 (72 h) 2.321 mg/L [1]
EC50 (48 h) 33.8 - 5 890 µg/L [47]
LC50 (7 days) 2.24 - 11.7 mg/L [2]
LC50 (4 days) 3.29 - 429 mg/L [3]

Type of Study provided
Studies with data
Key study 39
Supporting study 50
Weight of evidence 9 5
Other 36
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 81 studies submitted
  • 58 studies processed
P/RResults
NOEC (8 months) 8.3 - 13.8 µg/L [2]
NOEC (3.767 months) 334.3 µg/L [1]
NOEC (3.333 months) 11 - 19.1 µg/L [2]
NOEC (63 days) 13 µg/L [1]
NOEC (56 days) 10 µg/L [1]

Type of Study provided
Studies with data
Key study 16
Supporting study 19 1
Weight of evidence 42
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 41 studies submitted
  • 21 studies processed
P/RResults
EC50 (10 days) 32 µg/L [1]
EC50 (7 days) 24.1 - 32 µg/L [2]
EC50 (4 days) 47 - 71 314 µg/L [2]
EC50 (72 h) 16.5 - 987 µg/L [89]
NOEC (19 days) 10.2 - 50.1 µg/L [3]

Type of Study provided
Studies with data
Key study 6
Supporting study 10
Weight of evidence 9 6
Other 9
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
197 µg/L
EC50 for marine water algae
24.1 µg/L
EC10 or NOEC for freshwater algae
66.9 µg/L
EC10 or NOEC for marine water algae
1.23 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 14 studies submitted
  • 4 studies processed
P/RResults
EC50 (7 days) 19.29 - 565.3 µg/L [13]
NOEC (7 days) 3 - 32.9 µg/L [14]
LOEC (7 days) 8.24 - 67.9 µg/L [13]
EC10 (7 days) 4.79 - 62.17 µg/L [13]
EC20 (7 days) 8.28 - 108.12 µg/L [12]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence 1
Other 6
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 20 studies submitted
  • 6 studies processed
P/RResults
EC50 (3.333 months) 25 µg/L [1]
EC50 (30 min) 120 mg/L [1]
NOEC (30 days) 230 - 450 µg/L [2]
NOEC (4 days) 3.818 mg/L [1]
NOEC (48 h) 3.563 - 3.8 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 10
Weight of evidence 5
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
120 mg/L
EC10 or NOEC for microorganisms
3.73 mg/L

Sediment toxicity

Study results
  • 23 studies submitted
  • 15 studies processed
P/RResults
NOEC (42 days) 469 - 1 786.7 mg/kg sediment dw [6]
NOEC (35 days) 30.6 - 97.4 mg/kg sediment dw [4]
NOEC (28 days) 18.3 - 4 384 mg/kg sediment dw [66]
NOEC (28 days) 9.84 - 23.56 mg/L [6]
NOEC (21 days) 23.4 - 44.9 mg/kg sediment dw [6]

Type of Study provided
Studies with data
Key study 8
Supporting study 4
Weight of evidence 7
Other 4
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
1 703 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
698 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 30 studies submitted
  • 24 studies processed
P/RResults
NOEC (10 years) 42.3 - 105.3 mg/kg soil dw [8]
NOEC (9.8 months) 139.6 mg/kg soil dw [1]
NOEC (4.833 months) 34 - 64.6 mg/kg soil dw [3]
NOEC (3.667 months) 73 - 150 mg/kg soil dw [2]
NOEC (84 days) 56 - 150 mg/kg soil dw [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 6
Weight of evidence 21
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 16 studies submitted
  • 15 studies processed
P/RResults
EC10 (28 days) 14.3 - 1 390 mg/kg soil dw [14]
EC10 (21 days) 141 - 888 mg/kg soil dw [6]
NOEC (56 days) 200 - 800 mg/kg soil dw [2]
NOEC (42 days) 200 - 1 000 mg/kg soil dw [2]
NOEC (28 days) 27.9 - 1 000 mg/kg soil dw [48]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence 12
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 34 studies submitted
  • 16 studies processed
P/RResults
NOEC (28 days) 42 mg/kg soil dw [1]
NOEC (21 days) 9 - 34 mg/kg soil dw [3]
NOEC (4 days) 42 - 180 mg/kg soil dw [4]
EC10 (7 months) 42 - 158 mg/kg soil dw [2]
EC10 (6.533 months) 181 - 192 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1 13
Supporting study 11 1
Weight of evidence 8
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 20 studies submitted
  • 14 studies processed
P/RResults
NOEC (1.573 years) 400 mg/kg soil dw [1]
NOEC (1.479 years) 55 - 400 mg/kg soil dw [3]
NOEC (1.342 years) 150 mg/kg soil dw [1]
NOEC (49 days) 118 - 468 mg/kg soil dw [3]
NOEC (28 days) 25 - 2 400 mg/kg soil dw [24]

Type of Study provided
Studies with data
Key study 3
Supporting study 5 1
Weight of evidence 11
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 3
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (3.733 months) 200 mg/kg diet [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 80 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 5
Supporting study 42 1
Weight of evidence 26 1
Other 5
Data waiving
no waivers
Study data: dermal absorption
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 4
Supporting study 1
Weight of evidence 4
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 4 studies processed
P/RResults
LD50 300 - 2 500 mg/kg bw (rat) [5]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 50 - 4 740 mg/m³ air (rat) [6]
LC0 (4 h) 1.14 mg/L air (rat) [1]
M/CInterpretations of results
Category 1 based on GHS criteria [1]

inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
dermal
  • 7 studies submitted
  • 6 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [6]
M/CInterpretations of results
GHS criteria not met [3]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 23 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 3 mg/kg bw/day [1]
NOAEL (rat): 1 000 ppm [1]
NOAEL (mouse): 1 000 ppm [1]
LOAEL (rat): 2 000 ppm [1]
LOAEL (mouse): 2 000 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 15
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study 10
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Genetic toxicity

Study results
Study data: in vitro
  • 54 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1
Supporting study
Weight of evidence 41
Other 9
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Study data: in vivo
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 1
Weight of evidence 12
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 11 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other 7
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant