EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

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Last updated 21 January 2022. Database contains 4753 unique substances/entries.
Substance Name EC No. CAS No. EU CLP (1272/2008) EU_BA Directive 2000/54/EC EU REACH: List of SVHC
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Bis[(trimethylsilyl)methyl]mercury ecnumber: 236-315-7 | casnumber: 13294-23-0
2-ethoxyethylmercury chloride ecnumber: 204-670-7 | casnumber: 124-01-6
Mercury difulminate ecnumber: 211-057-8 | casnumber: 628-86-4
(bromodichloromethyl)phenylmercury ecnumber: 221-961-4 | casnumber: 3294-58-4
Mercury, iodo(trifluoromethyl)- ecnumber: - | casnumber: 421-11-4
6-methyl-3-nitrobenzoxamercurete ecnumber: 205-112-5 | casnumber: 133-58-4
(dihydroxyphenyl)phenylmercury ecnumber: 248-426-8 | casnumber: 27360-58-3
(2-carboxyphenyl)hydroxymercury ecnumber: 237-918-8 | casnumber: 14066-61-6
2-ethoxyethylmercury acetate ecnumber: 204-678-0 | casnumber: 124-08-3
Phenylmercury chloride ecnumber: 202-865-1 | casnumber: 100-56-1
Mercury, iodophenyl- ecnumber: 664-429-0 | casnumber: 823-04-1
(3-chloro-4-hydroxyphenyl)mercury;hydrate ecnumber: - | casnumber: 538-04-5
Phenyl(trichloromethyl)mercury ecnumber: 221-960-9 | casnumber: 3294-57-3
Iodomethylmercury ecnumber: 205-600-8 | casnumber: 143-36-2
Phenylmercury dimethyldithiocarbamate ecnumber: 251-026-6 | casnumber: 32407-99-1
4-aminophenylmercury acetate ecnumber: 228-497-1 | casnumber: 6283-24-5
Mercurate(2-), tetraiodo-, copper(2+) (1:1), (T-4)- ecnumber: - | casnumber: 27228-67-7
[μ-[orthoborato(2-)-O:O']]diphenyldimercury ecnumber: 228-465-7 | casnumber: 6273-99-0
Chipcote ecnumber: - | casnumber: 2597-97-9
Disuccinimidomercury ecnumber: 209-537-7 | casnumber: 584-43-0
(oleato)phenylmercury ecnumber: 203-218-6 | casnumber: 104-60-9
Dimethylmercury ecnumber: 209-805-3 | casnumber: 593-74-8
Di-o-tolylmercury ecnumber: 210-499-9 | casnumber: 616-99-9
4-(Chloromercuri)benzenesulfonic acid monosodium salt ecnumber: 683-356-5 | casnumber: 14110-97-5
Mercuderamide ecnumber: 208-371-2 | casnumber: 525-30-4
Amminephenylmercury(1+) acetate ecnumber: 245-006-6 | casnumber: 22450-90-4
Sodium timerfonate ecnumber: 227-741-4 | casnumber: 5964-24-9
Mercury(1+) trifluoroacetate ecnumber: 220-875-4 | casnumber: 2923-15-1
Chloromethylmercury ecnumber: 204-064-2 | casnumber: 115-09-3
Mercury(2+) chloroacetate ecnumber: 247-925-8 | casnumber: 26719-07-3
Tris(ethylmercury) phosphate ecnumber: 218-790-2 | casnumber: 2235-25-8
[2-ethylhexyl hydrogen maleato-O']phenylmercury ecnumber: 248-559-1 | casnumber: 27605-30-7
Mercury dibenzoate ecnumber: 209-499-1 | casnumber: 583-15-3
Ethylhydroxymercury ecnumber: - | casnumber: 107-28-8
Trimercury biscitrate ecnumber: 242-096-9 | casnumber: 18211-85-3
[μ-[(oxydiethylene but-2-enedioato)(2-)]]diphenyldimercury ecnumber: 301-791-8 | casnumber: 94070-92-5
Mercury, chloro(4-((2,4-dinitrophenyl)amino)phenyl)- ecnumber: - | casnumber: 15785-93-0
Diiodobis(5-iodopyridin-2-amine)mercury dihydroiodide ecnumber: 264-100-8 | casnumber: 63325-16-6
2-methoxyethylmercury chloride ecnumber: 204-659-7 | casnumber: 123-88-6
Methyl(pentachlorophenolato)mercury ecnumber: 227-596-7 | casnumber: 5902-76-1
Sodium 4-hydroxymercuriobenzoate ecnumber: 205-340-5 | casnumber: 138-85-2
Diphenylmercury ecnumber: 209-606-1 | casnumber: 587-85-9
(lactato-O1,O2)mercury ecnumber: 242-673-5 | casnumber: 18918-06-4
Diiodo(5-iodopyridin-2-amine-N1)mercury ecnumber: 298-602-3 | casnumber: 93820-20-3
(acetato-O)diamminephenylmercury ecnumber: 269-247-1 | casnumber: 68201-97-8
(acetato-O)ethylmercury ecnumber: 203-688-2 | casnumber: 109-62-6
(2,3,4,5,6-pentachlorophenoxy)-phenylmercury ecnumber: - | casnumber: 1142-64-9
Ethylmercury chloride ecnumber: 203-478-0 | casnumber: 107-27-7
Phenylmercury hydroxide ecnumber: 202-866-7 | casnumber: 100-57-2
1H-Tetrazole, 5-nitro-, mercury(2+) salt ecnumber: - | casnumber: 60345-95-1
Diphenyl[μ-[(tetrapropenyl)succinato(2-)-O:O']]dimercury ecnumber: 248-355-2 | casnumber: 27236-65-3
[salicylato(2-)-O1,O2]mercury ecnumber: 227-760-8 | casnumber: 5970-32-1
Sodium 4-chloromercuriobenzoate ecnumber: 221-700-4 | casnumber: 3198-04-7
[μ-[(oxydiethylene phthalato)(2-)]]diphenylmercury ecnumber: 301-792-3 | casnumber: 94070-93-6
Merbromin ecnumber: 204-933-6 | casnumber: 129-16-8
Bromoethylmercury ecnumber: 203-477-5 | casnumber: 107-26-6
Amylmercury chloride ecnumber: - | casnumber: 544-15-0
Mercury acetate ecnumber: 209-766-2 | casnumber: 592-63-2
p-tolylmercury chloride ecnumber: 208-716-7 | casnumber: 539-43-5
Hydrogen [metasilicato(2-)-O](2-methoxyethyl)mercurate(1-) ecnumber: 264-920-6 | casnumber: 64491-92-5
Chlormerodrin ecnumber: 200-530-4 | casnumber: 62-37-3
Mercury, diheptyl- ecnumber: - | casnumber: 51622-02-7
Mercury succinate ecnumber: 209-656-4 | casnumber: 589-65-1
(metaborato-O)phenylmercury ecnumber: 250-518-8 | casnumber: 31224-71-2
Dihydrogen [orthoborato(3-)-O]phenylmercurate(2-) ecnumber: 203-068-1 | casnumber: 102-98-7
Mercury, (acetato-O)(methylphenyl)- ecnumber: - | casnumber: 1300-78-3
Methylmercury benzoate ecnumber: 222-834-6 | casnumber: 3626-13-9
[2,2',2''-nitrilotri(ethanol)-N,O,O',O'']phenylmercury lactate ecnumber: 245-581-3 | casnumber: 23319-66-6
Mercurous gluconate ecnumber: - | casnumber: 63937-14-4
Mercury, hydroxy(hydroxynitrophenyl)-, monosodium salt ecnumber: - | casnumber: 1300-34-1
(2-carboxy-m-tolyl)hydroxymercury, monosodium salt ecnumber: 258-195-5 | casnumber: 52795-88-7
Bromo(2-hydroxypropyl)mercury ecnumber: 242-613-8 | casnumber: 18832-83-2
Bis(ethylthio)mercury ecnumber: - | casnumber: 811-50-7
Octadecanoic acid, mercury(1+) salt ecnumber: - | casnumber: 86320-46-9
[naphthoato(1-)-O]phenylmercury ecnumber: 250-736-3 | casnumber: 31632-68-5
4-Chloromercuriphenol ecnumber: - | casnumber: 623-07-4
(phenylmercurio)urea ecnumber: 218-909-8 | casnumber: 2279-64-3
basic phenylmercury nitrate ecnumber: 620-403-0 | casnumber: 8003-05-2
(acetato-O)[3-(chloromethoxy)propyl-C,O]mercury ecnumber: 227-719-4 | casnumber: 5954-14-3
Mercury di(acetate) ecnumber: 216-491-1 | casnumber: 1600-27-7
Mercury, bis(phenylmethyl)- ecnumber: 677-698-4 | casnumber: 780-24-5
1-cyano-3-(methylmercurio)guanidine ecnumber: 207-935-5 | casnumber: 502-39-6
Bromomethylmercury ecnumber: 208-057-5 | casnumber: 506-83-2
Diethylmercury ecnumber: 211-000-7 | casnumber: 627-44-1
Bis(5-oxo-L-prolinato-N1,O2)mercury ecnumber: 305-388-8 | casnumber: 94481-62-6
Chloropropylmercury ecnumber: - | casnumber: 2440-40-6
Mercury bis(trifluoroacetate) ecnumber: 236-250-4 | casnumber: 13257-51-7
(Trifluoromethyl)mercuric bromide ecnumber: - | casnumber: 421-09-0
Mercurate(1-), [dodecenylbutanedioato(2-)-O']phenyl-, hydrogen ecnumber: 304-575-1 | casnumber: 94276-88-7
Diisopropylmercury ecnumber: - | casnumber: 1071-39-2
Phenylmercury stearate ecnumber: 203-217-0 | casnumber: 104-59-6
Bis(5-oxo-DL-prolinato-N1,O2)mercury ecnumber: 304-523-8 | casnumber: 94276-38-7
Dibutylrtut ecnumber: - | casnumber: 629-35-6
Mersalyl ecnumber: 207-748-9 | casnumber: 492-18-2
Mercurobutol ecnumber: 207-869-7 | casnumber: 498-73-7
Mersalyl acid ecnumber: 207-637-5 | casnumber: 486-67-9
Hydroxymercury nitrile ecnumber: - | casnumber: 31065-88-0
Phenyl(quinolin-8-olato-N1,O8)mercury ecnumber: 238-316-8 | casnumber: 14354-56-4
[benzoato(2-)-C2,O1]mercury ecnumber: 227-228-5 | casnumber: 5722-59-8
[μ-[metasilicato(2-)-O:O]]bis(2-methoxyethyl)dimercury ecnumber: 242-997-7 | casnumber: 19367-79-4
3-(Acetoxymercuri)pyridine ecnumber: - | casnumber: 102-99-8
Meralein sodium ecnumber: 224-498-6 | casnumber: 4386-35-0
Bis[(+)-lactato]mercury ecnumber: 251-657-7 | casnumber: 33724-17-3
Phenylmercuric phthalate ecnumber: 664-337-0 | casnumber: 84-70-8
Chloro-o-tolylmercury ecnumber: 220-469-7 | casnumber: 2777-37-9
Chloro(trans-2-methoxycyclooctyl)mercury ecnumber: - | casnumber: 5185-84-2
BMC ecnumber: 663-974-1 | casnumber: 543-63-5
4-Chloromercuribenzenesulfonate ecnumber: - | casnumber: 554-77-8
(neodecanoato-O)phenylmercury ecnumber: 247-783-7 | casnumber: 26545-49-3
2-Chloromercuri-4-nitrophenol ecnumber: - | casnumber: 24579-90-6
2-hydroxy-5-(1,1,3,3-tetramethylbutyl)phenylmercury acetate ecnumber: 209-534-0 | casnumber: 584-18-9
(maleoyldioxy)bis[phenylmercury] ecnumber: 220-286-2 | casnumber: 2701-61-3
(2-ethylhexanoato)phenylmercury ecnumber: 236-326-7 | casnumber: 13302-00-6
Mercury, bis(3-fluorophenyl)- ecnumber: - | casnumber: 1961-02-0
Mercury, (acetato)pyridyl- (8CI) ecnumber: - | casnumber: 1334-77-6
Phenylmercury nitrate ecnumber: 200-242-9 | casnumber: 55-68-5
Iodo(iodomethyl)mercury ecnumber: 205-485-4 | casnumber: 141-51-5
4-hydroxymercuric?phenyl sulfonic acid, sodium salt ecnumber: - | casnumber: 73548-15-9
Mercury hydrogen cyclohexanebutyrate ecnumber: 263-665-8 | casnumber: 62638-02-2
Disodium tetra(cyano-C)mercurate(2-) ecnumber: 239-766-8 | casnumber: 15682-88-9
mercury, chloro(3-hydroxyphenyl)- ecnumber: - | casnumber: 70538-27-1
Naphthenic acids, mercury salts ecnumber: 215-651-8 | casnumber: 1336-96-5
[(2-hydroxyethyl)amino]phenylmercury acetate ecnumber: 263-211-9 | casnumber: 61792-06-1
Chloro-m-tolylmercury ecnumber: 227-722-0 | casnumber: 5955-19-1
2-Acetoxymercurio-4-nitrophenol ecnumber: - | casnumber: 63468-53-1
Phenylmercury benzoate ecnumber: 202-331-8 | casnumber: 94-43-9
Bromophenylmercury ecnumber: 214-760-8 | casnumber: 1192-89-8
Di(phenylmercury) dodecylsuccinate ecnumber: - | casnumber: 24806-32-4
Mercaptomerin sodium ecnumber: 244-298-2 | casnumber: 21259-76-7
Phenylmercury propionate ecnumber: 203-094-3 | casnumber: 103-27-5
Mercury(2+) (9Z,12Z)-octadeca-9,12-dienoate ecnumber: 231-814-6 | casnumber: 7756-49-2
Mercury bis(4-chlorobenzoate) ecnumber: 239-548-2 | casnumber: 15516-76-4
Mercury, (nitrate-O)(trifluoromethyl)- ecnumber: - | casnumber: 461-40-5
Ethanethiolmercury chloride ecnumber: - | casnumber: 1785-43-9
Hydrargaphen ecnumber: 238-107-1 | casnumber: 14235-86-0
Dipropyl mercury ecnumber: - | casnumber: 628-85-3
Dimercury di(acetate) ecnumber: 211-161-3 | casnumber: 631-60-7
Bis(trichloromethyl)mercury ecnumber: 229-867-5 | casnumber: 6795-81-9
Chloro-2-thienylmercury ecnumber: 227-481-1 | casnumber: 5857-39-6
Methylmercury hydroxide ecnumber: 214-667-2 | casnumber: 1184-57-2
(Pentafluorophenyl)mercury ecnumber: - | casnumber: 973-17-1
Mercury(2+) tetrakis(thiocyanato-N)cobaltate(2-) ecnumber: 248-602-4 | casnumber: 27685-51-4
2-chloromercuriophenol ecnumber: 201-962-6 | casnumber: 90-03-9
Di(acetato-O)anilinemercury ecnumber: 264-306-8 | casnumber: 63549-47-3
Phenylmercury acetate ecnumber: 200-532-5 | casnumber: 62-38-4
Mercury(1+) ethyl sulphate ecnumber: 275-904-3 | casnumber: 71720-55-3
methylmercury salts ecnumber: 694-823-8 | casnumber: 22967-92-6
Dipotassium tetracyanomercurate ecnumber: 209-735-3 | casnumber: 591-89-9
Di-sec-butylmercury ecnumber: - | casnumber: 691-88-3
Mercury distearate ecnumber: 211-458-8 | casnumber: 645-99-8
N-(ethylmercurio)toluene-4-sulphonanilide ecnumber: 208-231-0 | casnumber: 517-16-8
Hydrogen μ-hydroxy[μ-[orthoborato(3-)-O:O']]diphenyldimercurate(1-) ecnumber: 304-637-8 | casnumber: 94277-53-9
Chloro(hydroxyphenyl)mercury ecnumber: 215-308-2 | casnumber: 1320-80-5
Chloro[p-[(2-hydroxy-1-naphthyl)azo]phenyl]mercury ecnumber: 221-358-6 | casnumber: 3076-91-3
Dimethyl[μ-[sulphato(2-)-O:O']]dimercury ecnumber: 223-288-1 | casnumber: 3810-81-9
Di-p-tolylmercury ecnumber: 208-672-9 | casnumber: 537-64-4
Chloromercuriferrocene ecnumber: 631-381-7 | casnumber: 1273-75-2
Mercury dithizonate ecnumber: 621-496-0 | casnumber: 14783-59-6
(4-((4-(Dimethylamino)phenyl)azo)phenyl)mercuric acetate ecnumber: 631-561-5 | casnumber: 19447-62-2
Ethyliodomercury ecnumber: 219-471-0 | casnumber: 2440-42-8
Mercury, chloropyridinyl- ecnumber: - | casnumber: 1334-75-4
Mercury bis(2-ethylhexanoate) ecnumber: 236-113-9 | casnumber: 13170-76-8
2-methoxyethylmercury acetate ecnumber: 205-790-2 | casnumber: 151-38-2
Phenylmercury salicylate ecnumber: 248-828-3 | casnumber: 28086-13-7
4-chloromercuriobenzoic acid ecnumber: 200-442-6 | casnumber: 59-85-8
Otimerate sodium ecnumber: 240-572-0 | casnumber: 16509-11-8
Mercury dioleate ecnumber: 214-741-4 | casnumber: 1191-80-6
Lactic acid, mercury(2+) salt (2:1) (8CI) ecnumber: - | casnumber: 814-82-4
(acetato-O)methylmercury ecnumber: 203-547-5 | casnumber: 108-07-6
Thiomersal ecnumber: 200-210-4 | casnumber: 54-64-8
Bis(ethylmercuri)phosphate ecnumber: - | casnumber: 2440-45-1
2-(ethylmercuriothio)benzoic acid ecnumber: 205-719-5 | casnumber: 148-61-8
Lactatophenylmercury ecnumber: 204-560-9 | casnumber: 122-64-5
Phenyl(tribromomethyl)mercury ecnumber: 221-963-5 | casnumber: 3294-60-8
Bis(lactato-O1,O2)mercury ecnumber: 242-667-2 | casnumber: 18917-83-4
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Acute Tox. 2; Acute Tox. 1; STOT RE 2

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