EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

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Last updated 17 April 2024. Database contains 4753 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
EU REACH: List of SVHC
ε-caprolactam
203-313-2
105-60-2
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
α[2-[[[(2-hydroxyethyl)methylamino]acetyl]amino]propyl]-ω nonylphenoxy)poly[oxo(methyl-1,2-ethanediyl)]
PC-709
413-420-8
144736-29-8
Skin Corr. 1B; Skin Sens. 1
α-hydroxypoly(methyl-(3-(2,2,6,6-tetramethylpiperidin-4-yloxy)propyl)siloxane)
639-478-6
182635-99-0
Acute Tox. 4; Skin Corr. 1B
α-cypermethrin (ISO); racemate comprising (R)-α-cyano-3-phenoxybenzyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate; (S)-α-cyano-3-phenoxybenzyl(1R, 3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
614-054-3
67375-30-8
Acute Tox. 3; STOT RE 2; STOT SE 3
α-chlorotoluene; benzyl chloride
202-853-6
100-44-7
Carc. 1B; Acute Tox. 3; Acute Tox. 4; STOT RE 2; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
α-bromotoluene; benzyl bromide
202-847-3
100-39-0
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
α-[3-(1-oxoprop-2-enyl)l-1-oxypropyl]dimethoxysilyloxy-ω-[3(1-oxoprop-2-enyl)-1-oxypropyl]dimethoxysilyl poly(dimethylsiloxane)
ACRYLOXYPROPYL DIMETHOXYSILOXY TERMINATED POLYDIMETHYL SILOXANE
415-290-8
193159-06-7
Skin Sens. 1
α,α-Bis[4-(dimethylamino)phenyl]-4 (phenylamino)naphthalene-1-methanol; C.I. Solvent Blue 4
229-851-8
6786-83-0
yes
α, α-dimethylbenzyl hydroperoxide; cumene hydroperoxide
201-254-7
80-15-9
Org. Perox. E; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Skin Corr. 1B
α, α-dichlorotoluene; benzylidene chloride; benzal chloride
202-709-2
98-87-3
Carc. 2; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
α, α, α-trifluorotoluene; benzotrifluoride
202-635-0
98-08-8
Flam. Liq. 2
α, α, α-trichlorotoluene; benzotrichloride
202-634-5
98-07-7
Carc. 1B; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
α, α, α,4-tetrachlorotoluene; p-chlorobenzotrichloride
226-009-1
5216-25-1
Carc. 1B; Repr. 2; STOT RE 1; Acute Tox. 4; STOT SE 3; Skin Irrit. 2
zoxamide (ISO); (RS)-3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-p-toluamide
605-037-1
156052-68-5
Skin Sens. 1
zirconium powder (pyrophoric);zirconium powder, dry (non pyrophoric)
231-176-9
7440-67-7
Water-react. 1; Pyr. Sol. 1
zirconium powder (pyrophoric);zirconium powder, dry (non pyrophoric)
231-176-9
7440-67-7
Self-heat. 1
Zirconia Aluminosilicate Refractory Ceramic Fibres
936-037-2
-
yes
ziram (ISO); zinc bis dimethyldithiocarbamate
205-288-3
137-30-4
Acute Tox. 2; Acute Tox. 4; STOT RE 2; STOT SE 3; Eye Dam. 1; Skin Sens. 1
zineb (ISO); zinc ethylenebis(dithiocarbamate) (polymeric)
235-180-1
12122-67-7
STOT SE 3; Skin Sens. 1
zinc-bis(4-(n-octyloxycarbonylamino)salicylate) dihydrate
417-130-2
1379689-21-0
Eye Dam. 1
zinc sulphate (hydrous) (mono-, hexa-and hepta hydrate)
616-096-8
7446-19-7
Acute Tox. 4; Eye Dam. 1
zinc sulphate (anhydrous)
231-793-3
7733-02-0
Acute Tox. 4; Eye Dam. 1
zinc powder — zinc dust (pyrophoric)
231-175-3
7440-66-6
Water-react. 1; Pyr. Sol. 1
zinc hexacyanocobaltate(III), tertiary butyl alcohol/polypropylene glycol complex
425-240-7
-
Eye Dam. 1
zinc chromates including zinc potassium chromate
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C.I. Pigment Yellow 36 EC / List no: 609-398-6 | CAS no: 37300-23-5
Zinc dichromate EC / List no: 237-843-0 | CAS no: 14018-95-2
Chromic acid, potassium zinc salt EC / List no: 255-252-6 | CAS no: 41189-36-0
Zinc chromate EC / List no: 236-878-9 | CAS no: 13530-65-9
Pentazinc chromate octahydroxide EC / List no: 256-418-0 | CAS no: 49663-84-5
Potassium hydroxyoctaoxodizincatedichromate(1-) EC / List no: 234-329-8 | CAS no: 11103-86-9
-
-
Carc. 1A; Acute Tox. 4; Skin Sens. 1
zinc chloride
231-592-0
7646-85-7
Acute Tox. 4; Skin Corr. 1B
zinc bis(diethyldithiocarbamate)
238-270-9
14324-55-1
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
zinc bis(dibutyldithiocarbamate)
205-232-8
136-23-2
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
zinc 2-hydroxy-5-C13-18 alkylbenzoate
Z-6
402-280-3
149144-82-1
Eye Irrit. 2; Skin Irrit. 2
xylylcarb (ISO); 3,4-dimethylphenyl N-methylcarbamate; 3,4-xylyl methylcarbamate; MPMC
219-364-9
2425-10-7
Acute Tox. 4
xylidines with the exception of those specified elsewhere in this Annex; dimethyl anilines with the exception of those specified elsewhere in this Annex
215-091-4
1300-73-8
Acute Tox. 3; STOT RE 2
xylenol
215-089-3
1300-71-6
Acute Tox. 3; Skin Corr. 1B
xylene
215-535-7
1330-20-7
Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2
XMC; 3,5-xylyl methylcarbamate
607-955-8
2655-14-3
Acute Tox. 4
white phosphorus
601-810-2
12185-10-3
Pyr. Sol. 1; Acute Tox. 2; Skin Corr. 1A
Waste solids, coal-tar pitch coking; Coal Tar Solids Residue [The combination of wastes formed by the coking of bituminous coal tar pitch. It consists predominantly of carbon.]
The combination of wastes formed by the coking of bituminous coal tar pitch. It consists predominantly of carbon.
295-549-8
92062-34-5
Carc. 1B
warfarin (ISO); 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one;
201-377-6
81-81-2
Repr. 1A; Acute Tox. 1; Acute Tox. 2; STOT RE 1
vinyl chloride; chloroethylene
200-831-0
75-01-4
Press. Gas; Flam. Gas 1; Carc. 1A
vinyl acetate
203-545-4
108-05-4
Flam. Liq. 2; Carc. 2; Acute Tox. 4; STOT SE 3
vinclozolin (ISO); N-3,5-dichlorophenyl-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione
256-599-6
50471-44-8
Carc. 2; Repr. 1B; Skin Sens. 1
vernolate (ISO); S-propyl dipropylthiocarbamate
217-681-7
1929-77-7
Acute Tox. 4
vanadyl pyrophosphate
BTN; VPO CATALYST
406-260-5
58834-75-6
Eye Irrit. 2; Skin Sens. 1
vanadium(IV) oxide hydrogen phosphate hemihydrate, lithium, zinc, molybdenum, iron and chlorine-doped
424-390-0
93280-40-1
Acute Tox. 4; STOT RE 2; Eye Dam. 1
vamidothion (ISO); O,O-dimethyl S-2-(1-methylcarbamoylethylthio) ethyl phosphorothioate
218-894-8
2275-23-2
Acute Tox. 3; Acute Tox. 4
valinamide
D,L-VALINEAMIDE
402-840-7
20108-78-5
Repr. 2; Eye Irrit. 2; Skin Sens. 1
valeric acid
203-677-2
109-52-4
Skin Corr. 1B
UVCB condensation product of: tetrakis-hydroxymethylphosphonium chloride, urea and distilled hydrogenated C16-18 tallow alkylamine
ITC 826 CONCENTRATE
422-720-8
166242-53-1
Carc. 2; Acute Tox. 4; STOT RE 2; Skin Corr. 1B; Skin Sens. 1
urethane (INN); ethyl carbamate
200-123-1
51-79-6
Carc. 1B
uranium compounds with the exception of those specified elsewhere in this Annex
show/hide
Uranium trioxide EC / List no: 215-701-9 | CAS no: 1344-58-7
[oxalato(2-)-O,O']dioxouranium EC / List no: 217-986-5 | CAS no: 2031-89-2
Uranium tetrafluoride EC / List no: 233-170-1 | CAS no: 10049-14-6
Uranium hydride (UH3) EC / List no: - | CAS no: 13598-56-6
Uranium hexafluoride EC / List no: 232-028-6 | CAS no: 7783-81-5
Uranium fluoride (U2F9) EC / List no: - | CAS no: 12134-48-4
Uranium pentafluoride EC / List no: 237-405-9 | CAS no: 13775-07-0
Uranium EC / List no: 231-170-6 | CAS no: 7440-61-1
Bis(formato-O)dioxouranium EC / List no: 241-063-6 | CAS no: 16984-59-1
Uranium nitrate EC / List no: - | CAS no: 13826-82-9
Calcines, uranium ore-conc.
Calcined precipitates of ammonium, magnesium or sodium uranates obtained from natural uranium ores.
EC / List no: 297-819-0 | CAS no: 93763-02-1
Uranium dioxideperoxide EC / List no: 234-852-1 | CAS no: 12036-71-4
Lead uranate pigment EC / List no: 287-565-9 | CAS no: 85536-79-4
Dioxobis(pentane-2,4-dionato-O,O')uranium EC / List no: 241-951-3 | CAS no: 18039-69-5
Uranium carbide (UC) EC / List no: - | CAS no: 12070-09-6
Nickel uranyl tetraacetate, of uranium depleted in uranium-235 EC / List no: 275-994-4 | CAS no: 71767-12-9
Dichlorodioxouranium EC / List no: 232-246-1 | CAS no: 7791-26-6
Magnesium diuranium heptaoxide EC / List no: 236-982-4 | CAS no: 13568-61-1
Resin acids and Rosin acids, uranyl salts EC / List no: 273-325-0 | CAS no: 68956-97-8
Triuranium octaoxide EC / List no: 215-702-4 | CAS no: 1344-59-8
Uranium disilicide EC / List no: 234-906-4 | CAS no: 12039-85-9
Barium uranium oxide EC / List no: - | CAS no: 10380-31-1
polysilicate EC / List no: - | CAS no: 12427-14-4
Zinc bis(acetato-O)dioxouranate EC / List no: 233-390-8 | CAS no: 10138-94-0
Disodium uranium tetraoxide EC / List no: 236-846-4 | CAS no: 13510-99-1
Uranium tetrabromide EC / List no: 236-734-5 | CAS no: 13470-20-7
Uranium trifluoride EC / List no: 237-404-3 | CAS no: 13775-06-9
Magnesium uranium(4+) hexaacetate EC / List no: 243-905-8 | CAS no: 20596-93-4
Dipotassium heptaoxodiuranate EC / List no: 232-217-3 | CAS no: 7790-63-8
Uranyl acetate-2H2O EC / List no: 629-550-5 | CAS no: 6159-44-0
Uranium nitride EC / List no: - | CAS no: 12058-37-6
Uranium tetrachloride EC / List no: 233-057-7 | CAS no: 10026-10-5
Triuranium tetraphosphide EC / List no: 234-871-5 | CAS no: 12037-84-2
Acetic acid, uranium(4+) zinc salt EC / List no: 243-904-2 | CAS no: 20596-91-2
Difluorodioxouranium EC / List no: 236-898-8 | CAS no: 13536-84-0
Uranium carbide (UC2) EC / List no: - | CAS no: 12071-33-9
Uranium hydride EC / List no: 257-346-2 | CAS no: 51680-55-8
Sodium tris(benzeneacetato-O)dioxouranate(1-) EC / List no: 309-040-6 | CAS no: 99800-13-2
Uranium ditelluride EC / List no: 235-249-6 | CAS no: 12138-37-3
Disodium heptaoxodiuranate, of uranium depleted in uranium-235 EC / List no: 237-286-3 | CAS no: 13721-34-1
Uranium disulphide EC / List no: 234-884-6 | CAS no: 12039-14-4
Titanate(4-), oxobis[phosphato(3-)]-, barium (1:2), uranium-doped EC / List no: 309-550-9 | CAS no: 100403-10-9
Bis(2-ethylhexanoato-O)dioxouranium EC / List no: 267-849-9 | CAS no: 67939-77-9
Uranate(2-), tetrakis(acetato-O)-dioxo-, magnesium (1:1), (OC-6-11)- EC / List no: - | CAS no: 66735-86-2
Sodium uranyl triacetate, of uranium depleted in uranium-235 EC / List no: 241-714-4 | CAS no: 17712-38-8
Nickel triuranium decaoxide EC / List no: 239-876-6 | CAS no: 15780-33-3
Bis(nitrato-O,O')dioxouranium EC / List no: 253-053-9 | CAS no: 36478-76-9
Bis(acetato-O)dioxouranium EC / List no: 208-767-5 | CAS no: 541-09-3
Uranium diselenide EC / List no: 235-245-4 | CAS no: 12138-21-5
Uranium tetraiodide EC / List no: 236-735-0 | CAS no: 13470-22-9
Dioxo[sulphato(2-)-O]uranium EC / List no: 215-240-3 | CAS no: 1314-64-3
Tetrakis(pentane-2,4-dionato-O,O')uranium EC / List no: 265-498-6 | CAS no: 65137-03-3
Oxobis(pentane-2,4-dionato-O,O')uranium EC / List no: 254-311-3 | CAS no: 39136-40-8
Dipotassium uranyl bis(sulphate), of uranium depleted in uranium-235 EC / List no: 262-284-4 | CAS no: 60542-74-7
Diammonium diuranium heptaoxide EC / List no: 231-986-2 | CAS no: 7783-22-4
Uranium diboride EC / List no: 234-508-0 | CAS no: 12007-36-2
Tetraammonium uranyl tricarbonate, of uranium depleted in uranium-235 EC / List no: 241-988-5 | CAS no: 18077-77-5
Uranium dioxide EC / List no: 215-700-3 | CAS no: 1344-57-6
Calcium diuranium heptaoxide EC / List no: 237-428-4 | CAS no: 13780-21-7
Nitric acid, uranium salt EC / List no: - | CAS no: 15905-86-9
Nitric acid, uranium(6+) salt EC / List no: - | CAS no: 20820-60-4
Uranium tetraboride EC / List no: 234-520-6 | CAS no: 12007-84-0
Nasturan EC / List no: 690-098-7 | CAS no: 1317-99-3
Bis(nitrato-O)dioxouranium EC / List no: 233-266-3 | CAS no: 10102-06-4
Uranium triiodide EC / List no: 237-406-4 | CAS no: 13775-18-3
Zinc tetrakis(acetato-O)dioxouranate EC / List no: 251-762-8 | CAS no: 33959-50-1
Hydrogen dioxo[phosphato(3-)-O,O']uranate(1-) EC / List no: 242-306-9 | CAS no: 18433-48-2
-
-
Acute Tox. 2; STOT RE 2
uranium
231-170-6
7440-61-1
Acute Tox. 2; STOT RE 2
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