EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

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Last updated 24 April 2024. Database contains 4753 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
EU REACH: List of SVHC
dialuminium nickel tetraoxide
234-454-8
12004-35-2
Carc. 1A; STOT RE 1; Skin Sens. 1
diamminediisocyanatozinc
GENIPLEX A
401-610-3
122012-52-6
Acute Tox. 4; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diammonium 1-hydroxy-2-(4-(4-carboxyphenylazo)-2,5-dimethoxyphenylazo)-7-amino-3-naphthalenesulfonate
422-670-7
150202-11-2
Repr. 2; Acute Tox. 3; STOT RE 2
diammonium hexachloroplatinate
240-973-0
16919-58-7
Acute Tox. 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diammonium nickel bis(sulfate)
239-793-5
15699-18-0
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
diammonium nickel hexacyanoferrate
-
74195-78-1
Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
diammonium peroxodisulphate; ammonium persulphate
231-786-5
7727-54-0
Ox. Sol. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
diammonium tetrachloroplatinate
237-499-1
13820-41-2
Acute Tox. 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diarsenic pentaoxide; arsenic pentoxide; arsenic oxide
215-116-9
1303-28-2
Carc. 1A; Acute Tox. 3
yes
diarsenic trioxide; arsenic trioxide
215-481-4
1327-53-3
Carc. 1A; Acute Tox. 2; Skin Corr. 1B
yes
diazinon (ISO); O,O-diethyl O-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate
206-373-8
333-41-5
Acute Tox. 4
diazomethane
206-382-7
334-88-3
Carc. 1B
dibenz[a,h]anthracene
200-181-8
53-70-3
Carc. 1B
dibenzo[b,def]chrysene; dibenzo[a,h]pyrene
205-878-0
189-64-0
Carc. 1B; Muta. 2
dibenzo[def,p]chrysene; dibenzo[a,l]pyrene
205-886-4
191-30-0
Carc. 1B; Muta. 2
dibenzoyl peroxide; benzoyl peroxide
202-327-6
94-36-0
Org. Perox. B; Eye Irrit. 2; Skin Sens. 1
dibenzylphenylsulfonium hexafluoroantimonate
ZK RT 1507
417-760-8
134164-24-2
STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
diboron trioxide; boric oxide
215-125-8
1303-86-2
Repr. 1B
yes
dibromomethane
200-824-2
74-95-3
Acute Tox. 4
dibutyl phthalate; DBP
201-557-4
84-74-2
Repr. 1B
yes
dibutyl-3-(4-(5-ammonio-2-butyl)benzofuran-3-yl)carbonyl)phenoxy)propyl ammonium oxalate; (5-amino-2-butylbenzofuran-3-yl) [4-(3-dibutylaminopropoxy)phenyl]methanone, dioxalate
AMINODARONE OXALATE; SR33580A
448-700-9
500791-70-8
STOT RE 2; Eye Dam. 1; Skin Sens. 1
dibutylbis(pentane-2,4-dionato-O,O')tin
245-152-0
22673-19-4
Repr. 1B; STOT RE 1
yes
dibutyltin dichloride; (DBTC)
211-670-0
683-18-1
Muta. 2; Repr. 1B; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Corr. 1B
yes
dibutyltin dilaurate; dibutyl[bis(dodecanoyloxy)] stannane
201-039-8
77-58-7
Muta. 2; Repr. 1B; STOT RE 1
dibutyltin hydrogen borate
DBB
401-040-5
75113-37-0
Repr. 1B; Muta. 2; STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
dicamba (ISO); 2,5-dichloro-6-methoxybenzoic acid; 3,6-dichloro-2-methoxybenzoic acid
217-635-6
1918-00-9
Acute Tox. 4; Eye Dam. 1
dichlobenil (ISO); 2,6-dichlorobenzonitrile
214-787-5
1194-65-6
Acute Tox. 4
dichlofenthion (ISO); O—2,4-dichlorophenyl O,O-diethyl phosphorothioate
202-564-5
97-17-6
Acute Tox. 4
dichlofluanid (ISO); N-dichlorofluoromethylthio-N',N'-dimethyl-N-phenylsulfamide
214-118-7
1085-98-9
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
dichlone (ISO); 2,3-dichloro-1,4-naphthoquinone
204-210-5
117-80-6
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
dichloro-(3-(3-chloro-4-fluorophenyl)propyl)methylsilane
SILAN DCS
407-180-3
770722-36-6
Skin Corr. 1A
dichloro-1,3,5-triazinetrione; dichloroisocyanuric acid
220-487-5
2782-57-2
Ox. Sol. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
dichloroacetic acid
201-207-0
79-43-6
Skin Corr. 1A
dichloroacetyl chloride
201-199-9
79-36-7
Skin Corr. 1A
dichloroacetylene
620-404-6
7572-29-4
Unst. Expl.; Carc. 2; STOT RE 2
dichlorodioctyl stannane
222-583-2
3542-36-7
Repr. 1B; Acute Tox. 2; STOT RE 1
dichloromethane; methylene chloride
200-838-9
75-09-2
Carc. 2
dichlorophen (ISO)
202-567-1
97-23-4
Acute Tox. 4; Eye Irrit. 2
dichlorprop (ISO); 2-(2,4-dichlorophenoxy)propionic acid
204-390-5
120-36-5
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
dichlorprop-P (ISO); (+)-R-2-(2,4-dichlorophenoxy)propionic acid
D-2,4-DP; DICHLORPROP-P; DUPLOSAN DP-ACID
403-980-1
15165-67-0
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
dichlorvos (ISO); 2,2-dichlorovinyl dimethyl phosphate
200-547-7
62-73-7
Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
Dichromic acid
236-881-5
13530-68-2
yes
dichromium tris(chromate); chromium III chromate; chromic chromate
246-356-2
24613-89-6
Ox. Sol. 1; Carc. 1B; Skin Corr. 1A; Skin Sens. 1
yes
diclobutrazole (ISO);(R*, R*)-(±)-β-[(2,4-dichlorop henyl)methyl]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; (2RS, 3RS)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2- (1H—1,2,4-triazol-1yl)pentan-3-ol
620-436-0
75736-33-3
Eye Irrit. 2
diclofop-methyl (ISO)methyl 2-(4-(2,4-dichlorophenoxy)phenoxy)propionate; methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate
257-141-8
51338-27-3
Acute Tox. 4; Skin Sens. 1
dicofol (ISO); 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol
204-082-0
115-32-2
Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
dicopper chloride trihydroxide
215-572-9
1332-65-6
Acute Tox. 4; Acute Tox. 3
dicopper oxide; copper (I) oxide
215-270-7
1317-39-1
Acute Tox. 4; Eye Dam. 1
dicoumarol; 4,4'-dihydroxy-3,3'-methylenebis(2H-chromen-2-one)
200-632-9
66-76-2
STOT RE 1; Acute Tox. 4
dicrotophos (ISO); (Z)-2-dimethylcarbamoyl-1-methylvinyl dimethyl phosphate
205-494-3
141-66-2
Acute Tox. 2; Acute Tox. 3
dicyclohexyl phthalate
201-545-9
84-61-7
Repr. 1B; Skin Sens. 1
yes
dicyclohexylamine
202-980-7
101-83-7
Acute Tox. 4; Skin Corr. 1B
dicyclohexylammonium nitrite
221-515-9
3129-91-7
Acute Tox. 4
dicyclohexylcarbodiimide
208-704-1
538-75-0
Acute Tox. 3; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
dicyclopentyldimethoxysilane
DCPMS; DYNASYLAN 9415; EURENOR 5023; SAN-30; WACKER SILAN CP2-DIMETHOXY; Z-6228
404-370-8
126990-35-0
Skin Irrit. 2; Eye Dam. 1
didecyldimethylammonium chloride
230-525-2
7173-51-5
Acute Tox. 4; Skin Corr. 1B
dieldrin (ISO)
200-484-5
60-57-1
Carc. 2; Acute Tox. 1; Acute Tox. 3; STOT RE 1
diethanolamine perfluorooctane sulfonate
274-460-8
70225-14-8
Carc. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Lact.
diethanolamine salt of 4-CPA
-
-
Acute Tox. 4
diethyl 2,4-dihydroxycyclodisiloxane-2,4-diylbis(trimethylene)diphosphonate, tetrasodium salt, reaction products with disodium metasilicate
SIFOSIL; SIFOSIL KONZENTRAT G 96-00 FEST
401-770-4
148324-78-1
Skin Corr. 1B; Acute Tox. 4
diethyl ether; ether
200-467-2
60-29-7
Flam. Liq. 1; Acute Tox. 4; STOT SE 3
diethyl sulphate
200-589-6
64-67-5
Carc. 1B; Muta. 1B; Acute Tox. 4; Skin Corr. 1B
yes
diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
DAMA
426-790-0
162208-27-7
Acute Tox. 4; STOT RE 2; Skin Sens. 1
diethyl(ethyldimethylsilanolato) aluminium
CS 100; SILOXAL
401-160-8
55426-95-4
Water-react. 1; Pyr. Liq. 1; Skin Corr. 1A
diethyl[(p-ethoxyanilino)methylene]malonate
431-430-0
103976-28-9
Acute Tox. 4
diethylamine
203-716-3
109-89-7
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
diethylcarbamoyl chloride
201-798-5
88-10-8
Carc. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
diethyldimethylammonium hydroxide
DIETHYLDIMETHYLAMMONIUMHYDROXIDE
419-400-5
95500-19-9
Acute Tox. 4; Skin Corr. 1A
diethylmercury
211-000-7
627-44-1
Acute Tox. 2; Acute Tox. 1; STOT RE 2
diethylmethoxyborane
425-380-9
7397-46-8
Pyr. Liq. 1; Acute Tox. 4; STOT RE 2; Skin Corr. 1B; Skin Sens. 1
diethylmethylbenzenediamine
270-877-4
68479-98-1
Acute Tox. 4; STOT RE 2; Eye Irrit. 2
diethylzinc
209-161-3
557-20-0
Pyr. Liq. 1; Water-react. 1; Skin Corr. 1B
diethyl{4-[1,5,5-tris(4-diethylaminophenyl)penta-2,4-dienylidene]cyclohexa-2,5-dienylidene}ammonium butyltriphenylborate
IRB
418-070-1
141714-54-7
Skin Sens. 1
difethialone (ISO); 3-[3-(4'-bromobiphenyl-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2H-1-benzothiopyran-2-one
600-594-7
104653-34-1
Repr. 1B; Acute Tox. 1; STOT RE 1
digitoxin
200-760-5
71-63-6
Acute Tox. 3; STOT RE 2
dihexyl phthalate
201-559-5
84-75-3
Repr. 1B
yes
diisobutyl phthalate
201-553-2
84-69-5
Repr. 1B
yes
diisohexyl phthalate
276-090-2
71850-09-4
Repr. 1B
yes
diisooctyl phthalate
248-523-5
27554-26-3
Repr. 1B
diisopentylphthalate
210-088-4
605-50-5
Repr. 1B
yes
diisopropyl ether
203-560-6
108-20-3
Flam. Liq. 2; STOT SE 3
diisopropylamine
203-558-5
108-18-9
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1B
diketene; diketen
211-617-1
674-82-8
Flam. Liq. 3; Acute Tox. 4
dilauroyl peroxide
203-326-3
105-74-8
Org. Perox. D
dilithium 6-acetamido-4-hydroxy-3-(4-((2-sulphonatooxy)ethylsulphonyl) phenylazo)naphthalene-2-sulphonate
REACTIVE ORANGE F-64 258 FW
401-010-1
106027-83-2
Skin Sens. 1
dilithium disodium (5,5'-diamino-(μ-4,4'-dihydroxy-1:2κ-2,O4,O4',-3,3'-[3,3'-dihydroxy-1:2-κ-2-O3,O3'-biphenyl-4,4'-ylenebisazo-1:2-(N3, N4-η:N3', N4'-η)]-dinaphthalene-2,7-disulfonato(8)))dicuprate(2-)
BLUE GS 1259 R5
407-230-4
126637-70-5
Acute Tox. 4; Skin Sens. 1
dimefox (ISO); tetramethylphosphorodiamidic fluoride
204-076-8
115-26-4
Acute Tox. 1; Acute Tox. 2
dimepiperate (ISO);S-(1-methyl-1-phenylethyl) piperidine-1-carbothioate
262-784-2
61432-55-1
Acute Tox. 4
dimercury dichloride; mercurous chloride; calomel
233-307-5
10112-91-1
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
dimercury dicyanide oxide; mercuric oxycyanide
215-629-8
1335-31-5
Expl. 1.1; Acute Tox. 3; STOT RE 2
dimethachlor (ISO); 2-chloro-N-(2,6-dimethylphenyl)-N-(2-methoxyethyl)acetamide
256-625-6
50563-36-5
Acute Tox. 4; Skin Sens. 1
dimethenamid-P (ISO); 2-chloro-N-(2,4-dimethyl-3- thienyl)-N-[(2S)-1-methoxypropan-2-yl]acetamide
605-329-9
163515-14-8
Acute Tox. 4; Skin Sens. 1
dimethoate (ISO); O, O-dimethyl methylcarbamoylmethyl phosphorodithioate
200-480-3
60-51-5
Acute Tox. 4
dimethyl (2S)-2-hydroxysuccinate
432-310-0
617-55-0
Flam. Liq. 3; Eye Dam. 1; Skin Sens. 1
dimethyl (3-methyl-4-(5-nitro-3-ethoxycarbonyl-2-thienyl)azo)phenylnitrilodipropionate
C.I. DISPERSE BLUE 356
400-460-6
118578-14-6
Skin Sens. 1
dimethyl 4-(methylthio)phenyl phosphate
620-379-1
3254-63-5
Acute Tox. 1; Acute Tox. 2
dimethyl carbonate
210-478-4
616-38-6
Flam. Liq. 2
dimethyl disulphide
210-871-0
624-92-0
Flam. Liq. 2; Acute Tox. 3; STOT SE 3; STOT SE 1; Eye Irrit. 2; Skin Sens. 1
dimethyl ether
204-065-8
115-10-6
Flam. Gas 1; Press. Gas
dimethyl sulphate
201-058-1
77-78-1
Carc. 1B; Muta. 2; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
yes
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