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Annex III inventory

Annex III inventory

ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.

The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.

The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.

Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.

Download the full Annex III Inventory

You can download the full Annex III inventory as XLS format.

Download Annex III Inventory


Pentobarbital sodium

EC / List no.: 200-323-9 CAS no.: 57-33-0
Information source
# Suspected hazardous to the aquatic environment: The Danish QSAR database contains information indicating that the substance has a 96h EC50 to green algae of 9.78 mg/L # Suspected persistent in the environment: The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected skin sensitiser: The Toolbox profiler Protein binding alerts for skin sensitization by OASIS v1.3 gives an alert for skin sensitisation # Suspected toxic for reproduction: Developmental/Reproductive Toxicity library (PG) in VEGA (Q)SAR platform predicts that the chemical is Toxicant (good reliability); DART database in the Toolbox reports that this substance as Known developmental potential

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