Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Compilation of available data was provided in a WoE approach.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1938-1946
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Studies reported in scientific journals using different species and routes of administration.
Qualifier:
no guideline followed
Principles of method if other than guideline:
For details see text below
GLP compliance:
no
Test type:
other: For details see text below
Limit test:
no
Specific details on test material used for the study:
no data
Species:
other: Rabbit, Rat, Guinea Pig
Details on test animals or test system and environmental conditions:
na data
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
For details see text below
No. of animals per sex per dose:
For details see text below
Control animals:
not specified
Details on study design:
For details see text below
Key result
Sex:
not specified
Dose descriptor:
LD50
Remarks:
based on studies in rats (Ormond, 1938; Meier 1940)
Effect level:
> 2 000 mg/kg bw
Based on:
not specified
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification