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EC number: 202-124-2 | CAS number: 92-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28-Sep-2018 to 19-Oct-2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Remarks:
- The flask method was followed by a kinetic study
Test material
- Reference substance name:
- N-[2-[(4-amino-m-tolyl)ethylamino]ethyl]methanesulphonamide
- EC Number:
- 202-124-2
- EC Name:
- N-[2-[(4-amino-m-tolyl)ethylamino]ethyl]methanesulphonamide
- Cas Number:
- 92-09-1
- Molecular formula:
- C12H21N3O2S
- IUPAC Name:
- N-{2-[(4-amino-3-methylphenyl)(ethyl)amino]ethyl}methanesulfonamide
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- ca. 4 g/L
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: The substance is not stable in contact with water.
- Details on results:
- Within 2 hours of contact with water a water solubility of approximately to 4 g/L at pH 7 and 20°C could be estimated, but clear deterioration of the sample occurred with 24 hours.
Any other information on results incl. tables
Results of preliminary test
The preliminary test proved that the amount of dissolved active substance falls in the range between 1-10 g/L.
Unfortunately, the water solubility test of the test item was compromised by its stability problems. Indeed, during this visual test a marked variation in the colour of the solution (from pink to black) was detected.
Results of main test
Session 1
At time = 0 the chromatographic response showed no evident differences between the solution in diluted methanol and the solution diluted in HP water.
The analysis of the same solutions after 24 hours showed the solution in water had degraded by ca. 34% compared to the solution in methanol, which remained stable.
Session 2
The degradation in this case was even more marked than the first test. After 24 hours the solution in water had reached ca. 58% of the initial sample area.
Along with the area decrease, other substantial changes occurred to the appearance of both the stock solution in water and the preliminary test samples in water. The solutions changed in colour from pink to black, thus confirming degradation of the active ingredient.
The chromatograms obtained from solutions at different time points compared with the solution at time = 0 showed a continuous decrease in the concentration of the analyte in all the tested solutions.
Time (hour) |
mg found |
REC% vs T30min |
Solubility (g/L) |
0.5 |
38.12 |
- |
3.81 |
1 |
35.94 |
94.3 |
3.59 |
1.5 |
35.76 |
93.8 |
3.58 |
2 |
35.11 |
92.1 |
3.51 |
3 |
32.74 |
85.9 |
3.27 |
4 |
29.12 |
76.4 |
2.91 |
24 |
22.06 |
57.9 |
2.21 |
The study results showed that the test item is unstable in aqueous solutions, as well as being severely light sensitivity. For this reason no quantification of the water solubility was possible. The times required by the OECD 105 guideline covers a range of several days, while this study showed a clear deterioration within 24 hours.
As reported in the guideline, the solubility in water can be performed on “…essentially pure substances which are stable in water and not volatile”. Since this statement cannot be applied to the test item, the guideline cannot be followed in this case.
Conclusion
Study results showed that the test item N-(2 -4 -amino-n-ethyl-m-toluidino)ethyl)methanesulphonamide is unstable in aqueous solutions and is also severely light sensitive.
Within 2 hours of contact with water a water solubility of approximately 4 g/L at pH 7 and 25°C could be estimated, but clear deterioration of the sample occurs with 24 hours.
For this reason it was not possible to quantify the water solubility.
Applicant's summary and conclusion
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