Registration Dossier
Registration Dossier
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EC number: 203-328-4 | CAS number: 105-76-0
Endpoint summary
Administrative data
Description of key information
Dibutyl maleate is slightly irritating to the skin (RL1) and to the eyes (RL1).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The results of a semi-occlusive skin irritation study in rabbits performed with DBM (key study) showed lesions that were resolved by day 8. The test material was determined to be slightly irritating in all three rabbits during the observation period. However, one animal showed a well-defined dermal irritanting response on days 2 -3 only. There were other studies evaluated including some responses in humans. Information was limited but reliable enough for evaluation. Collectively, data suggest that DBM is a slightly to well defined irritating to the skin.
In addition, DBM was evaluated in an eye irritation/corrosion test. Based on the results from several reports, it was determined that the test substance may cause a well-defined conjunctival irritantion with a short recovery period of one or two days after exposure. Collectively, it was concluded that DBM is not irritating to the eyes.
Based on the overall response, DBM is considered slightly irritating to the skin and to the eyes.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
According to criteria in regulation (EC) No. 1272/2008, the substance is a mild or slightly skin irritant but does not require classification.
According to criteria in regulation (EC) No. 1272/2008, the substance is non classifiable as irritating to the eye.
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