Registration Dossier
Registration Dossier
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EC number: 203-372-4 | CAS number: 106-20-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Acutely toxic to fish.
Key value for chemical safety assessment
Additional information
In a BASF study conducted in 1983 the toxicity of the test substance on the Golden orfe (Leuciscus idus) was determined. Acetone was used in the preparation of the test solutions, but was removed prior to exposure. The test concentrations were not analytically verified. Undissolved test material was observed over the whole exposure period in the test concentrations 1.47 to 3.16 mg/L.The 96 -h LC50 was >1.5 and < 2.2 mg/L (BASF AG 83/228, 1983). The pH values were in the same magnitude in all concentrations throughout the test duration.
The supporting study (BASF SE 17F0454/11E135, 2013) was a screening test conducted with Danio rerio based on OECD 203. In this limit test, all fish died at the nominal concentration of 5 mg/L after 24 h of exposure.
The screening test was performed to proof the surprisingly high toxicity to fish of this substance compared to aquatic invertebrates and algae. Other members of this chemical class (amines) have a lower toxic effect to fish compared to the other trophic levels. In the available acute toxicity study (BASF AG, 1983; report no. 83/228) undissolved test substance was present in the test medium. In order to exclude that physical effects of these particles might have caused the high mortality instead of the inherent properties of the substance, the screening test was designed to eliminate the presence of undissolved test substance.
The test was designed as limit test with a test concentration slightly above the EC50 values for Daphnia and algae (5 mg/L). The number of fish was also minimised (n = 5). To ensure that the organisms were only exposed to dissolved test substance, the exposure was carried out in stainless steel aquaria into which are placed containment chambers consisting of a glass tube with a stainless steel mesh bottom. Undissolved substance remained on the water surface inside the containment chamber but no undissolved substance was observed outside.
All fish died within 24 h, which proved the high toxic effect of the test substance.
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