Registration Dossier
Registration Dossier
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EC number: 203-466-5 | CAS number: 107-13-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
An anonymous author (Japan MoE, 2011) reports a 48 -hour EC50 of 2.5 mg/L (mean measured) for acrylonitrile in Daphnia magna. This study was performed on behalf of the Japanese Ministry of the Environment in accordance with a Japanese national method equivalent to OECD TG 201 and in compliance with GLP. The test was conducted under static conditions in Elendt M4 medium with sealed test vessels to limit volatilisation losses of the test substance and maintain exposure concentrations.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.5 mg/L
Additional information
The Japan MoE (2011) study with D. magna was reliably performed, with appropriate measures to ensure that exposure to acrylonitrile was satisfactorily maintained, and is considered to provide the key acute toxicity endpoint for freshwater invertebrates. The 48 hour EC50 reported in Daphnia magna in four other studies is between 7.6-22 mg/L Neuparth et al. (2011) reported the results of a number of public domain studies where testing had been conducted on aquatic invertebrates. The 48-hour LC50 for Artemia salina was reported to be 14.34 mg/L. The 24 -hour LC50 for Crangon franciscorum was reported to be 10-33 mg/L.
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