Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-466-5 | CAS number: 107-13-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The data overall suggest that acrylonitrile, while having an initial inhibitory effect on microorganisms, is of relatively low toxicity at concentrations below 100 mg/l.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 50 mg/L
Additional information
Results of biodegradation testing shows that acrylonitrile has an initial inhibitory effect on non-acclimated microorganisms, but following acclimation EC50s for microorganisms are generally in excess of 100 mg/l. The results of microbial toxicity tests and biodegradation studies on acrylonitrile indicate a potential effect on microorganisms in wastewater treatment plants, at least on start-up. The reported EC50s range from 1- >1,800 mg/l. Results with acclimated microbial populations and in simulation tests have indicated no inhibitory effect of acrylonitrile at levels as high as 200 mg/l, and a conservative estimate of 50 mg/l for a NOEC in such populations has been assumed (EU RAR 2004).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
