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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-528-1 | CAS number: 107-87-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_guidance-on-safe-use.png)
Guidance on Safe Use
Administrative data
First-aid measures
4.1 Description of first aid measures
Inhalation: Move to fresh air. Treat symptomatically. Get medical attention if symptoms persist.
Eye contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact lenses. Get medical attention. In case of irritation from airborne exposure, move to fresh air. Get medical attention if symptoms persist.
Skin contact: Wash with soap and water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes.
Ingestion: Seek medical advice.
4.2 Most important symptoms and effects, both acute and delayed: Respiratory tract irritation. May irritate and cause redness and pain.
4.3 Indication of any immediate medical attention and special treatment needed
Hazards: Vapors have a narcotic effect and may cause headache, fatigue, dizziness and nausea.
Treatment: Treat symptomatically.
Fire-fighting measures
General fire hazards: Flammable liquid and vapor.
5.1 Extinguishing media
Suitable extinguishing media: Water spray. Dry chemical. Carbon Dioxide. Foam.
Unsuitable extinguishing media: None known.
5.2 Special hazards arising from the substance or mixture: Vapors may cause a flash fire or ignite explosively. Vapors may travel considerable distance to a source of ignition and flash back. Prevent buildup of vapors or gases to explosive concentrations. May form peroxides of unknown stability.
5.3 Advice for firefighters
Special fire fighting procedures: Water may be ineffective in fighting the fire. Use water spray to keep fire-exposed containers cool.
Special protective equipment for fire-fighters: Self-contained breathing apparatus and full protective clothing must be worn in case of fire.
Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures: Wear appropriate personal protective equipment.
6.2 Environmental precautions: Avoid release to the environment.
6.3 Methods and material for containment and cleaning up: Eliminate sources of ignition. Absorb spill with vermiculite or other inert material, then place in a container for chemical waste. Large Spillages: Use water spray to disperse vapors and dilute spill to a nonflammable mixture. Prevent runoff from entering drains, sewers, or streams. Dike for later disposal.
Notification Procedures: In the event of a spill or accidental release, notify relevant authorities in accordance with all applicable regulations.
Handling and storage
7.1 Precautions for safe handling: Avoid breathing mists or vapors. Avoid contact with eyes, skin, and clothing. Do not taste or swallow. Use only with adequate ventilation. Wash thoroughly after handling. Minimize exposure to air. After opening, purge container with nitrogen before reclosing. Periodically test for peroxide formation on long-term storage. Do not allow to evaporate to near dryness. Do not distill to near dryness. Addition of water or appropriate reducing materials will lessen peroxide formation.
7.2 Conditions for safe storage, including any incompatibilities: Keep container tightly closed and in a well-ventilated place. Keep away from food, drink and animal feedingstuffs. Store away from heat and light.
7.3 Specific end use(s): Solvent
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 1224
Shipping information
- Proper shipping name and description:
- KETONES, LIQUID, N.O.S.
- Chemical name:
- (methyl propyl ketone,methyl isobutyl ketone mixture)
- Language:
- English
- Labels:
- 3
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- 1224
Shipping information
- Proper shipping name and description:
- KETONES, LIQUID, N.O.S.
- Chemical name:
- (methyl propyl ketone,methyl isobutyl ketone mixture)
- Language:
- English
- Labels:
- 3
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 1224
Shipping information
- Proper shipping name and description:
- KETONES, LIQUID, N.O.S.
- Chemical name:
- (methyl propyl ketone,methyl isobutyl ketone mixture)
- Labels:
- 3
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 1224
Shipping information
- Proper shipping name and description:
- KETONES, LIQUID, N.O.S.
- Chemical name:
- (methyl propyl ketone,methyl isobutyl ketone mixture)
- Labels:
- 3
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
8.1 Control parameters
Occupational exposure limits
If exposure limits have not been established, maintain airborne levels to an acceptable level.
Chemical name Type Exposure Limit values Source
4-methylpentan-2-one; isobutyl methyl ketone
TWA 20 ppm 83 mg/m3 EU. Indicative Exposure Limit Values in Directives 91/322/EEC, 2000/39/EC, 2006/15/EC, 2009/161/EU (12 2009)
STEL 50 ppm 208 mg/m3 EU. Indicative Exposure Limit Values in Directives 91/322/EEC, 2000/39/EC, 2006/15/EC, 2009/161/EU (12 2009)
8.2 Exposure controls
Appropriate engineering controls: Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level.
Individual protection measures, such as personal protective equipment
General information: Eye bath. Washing facilities.
Eye/face protection: Wear safety glasses with side shields (or goggles). Wear a full-face respirator, if needed.
Skin protection
Hand protection: Wear chemical-resistant gloves, footwear, and protective clothing appropriate for the risk of exposure. Contact health and safety professional or manufacturer for specific information.
Other: No data available.
Respiratory Protection: If engineering controls do not maintain airborne concentrations below recommended exposure limits (where applicable) or to an acceptable level (in countries where exposure limits have not been established), an approved respirator must be worn. Respirator type: Air-purifying respirator with an appropriate, government approved (where applicable), air-purifying filter, cartridge or canister. Contact health and safety professional or manufacturer for specific information.
Hygiene measures: Observe good industrial hygiene practices.
Environmental Controls: No data available.
Stability and reactivity
10.1 Reactivity: None known.
10.2 Chemical stability: Stable
10.3 Possibility of hazardous reactions: May form peroxides of unknown stability.
10.4 Conditions to avoid: Heat, sparks, flames.
10.5 Incompatible materials: Strong oxidizing agents.
10.6 Hazardous decomposition products: Carbon Dioxide. Carbon Monoxide.
Disposal considerations
13.1 Waste treatment methods
General information: No data available.
Disposal methods: Dispose of waste and residues in accordance with local authority requirements. Mix with compatible chemical which is less flammable and incinerate. Since emptied containers retain product residue, follow label warnings even after container is emptied. Residual vapors may explode on ignition; do not cut, drill, grind, or weld on or near this container.
European Waste Codes
Comply with requirements of waste disposal legislation and any local authority requirements.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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