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EC number: 204-254-5 | CAS number: 118-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The predicted data suggests the effective concentration (EC50) for the test compound PyrazoloneTwas estimated to be 572.70123291mg/L on the basis of mortality.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 572.701 mg/L
Additional information
Various predicted data for chemical PyrazoloneTalong with its read across substance were reviewed to summarize the following information:
48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound PyrazoloneT(CAS no 118-47-8) and the results were predicted. The study was based on the effects of the test compound on the Zebra fish in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound PyrazoloneTwas estimated to be 572.70123291mg/L on the basis of mortality.
48 hrs aquatic toxicity study (EPI suite, 2016) was conducted to assess toxic effects of the test compoundPyrazoloneT(CAS no118-47-8) and the results were predicted. The study was based on the effects of the test compound on fish in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the test compoundPyrazoloneTwas estimated to be 6.46 x 105mg/l.
Short term toxicity study (Yaushide TONOGAL, Masahiro IWAIDA, Masatomo TATI, Youki OSE and Takahiko SATO,1978) toOryzias latipeswas carried out for 48 hrs and survival rate (in %) was determined. Himedaka (Oryzias latipes) of same age (2 cm long and 0.2 in weights) was used for the study. The test fishes were acclimatized for 10 days in tap water. In 1 litre solution of pH 7.0 containing 3,000 mg/l of test substance Tartrazine, ten fishes were kept in the tank without direct sunlight for 48 hrs and survival rate was determined. Water temperature was 20⁰C and aeration was provided with bubbler. Median Tolerance Limit (TLm) was also determined after 24 and 48 hrs. The TLm value was not reported. As no mortality of test animal was observed after 48 hrs, the LC0 value was found to be 3,000 mg/l. Thus, the survival rate of fish after 48 hrs was found to be 100%.
Short term toxicity study (Data bank of Environmental Properties of Chemicals (EnviChem))toOryzias latipeswas carried out for 48 hrs. The 48 hrs LC50 value to test organismOryzias latipeswas found to be greater than 1000 mg/l.
On the basis of results of various predictions and read across, the chemicalPyrazoloneT can be considered as not likely to be toxic to fishes at environmentally relevant concentrations and can be classified as non- hazardous as per the criteria of CLP regulation
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