Indole

Endpoint summary

Description of key information

Indole is skin sensitiser. Skin sens 1. (H317) May cause an allergic skin reaction.

The skin sensitization of the target Indole was predicted employing two different in silico approaches: the QSAR statistical model as provided by Vega and the decision rule system provided by Toxtree. In the case of the target Indole, Toxtree did not identify any skin sensitization reactivity domain alert, while Vega provided a positive prediction of moderate reliability. Thus, following a conservative approach, it was concluded that the target compound Indole is predicted as SKIN SENSITIZER and the prediction was assessed as moderate reliable.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in chemico

Remarks:

QSAR

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR

Principles of method if other than guideline:

QSAR

GLP compliance:

no

Details on the study design:

The skin sensitization of the target Indole was predicted employing two different in silico approaches: the QSAR statistical model as provided by Vega and the decision rule system provided by Toxtree. In the case of the target Indole, Toxtree did not identify any skin sensitization reactivity domain alert, while Vega provided a positive prediction of moderate reliability. Thus, following a conservative approach, it was concluded that the target compound Indole is predicted as SKIN SENSITIZER and the prediction was assessed as moderate reliable.

Key result

Run / experiment:

other: : the QSAR statistical model as provided by Vega and the decision rule system provided by Toxtree.

Parameter:

other: Skin sensitisation

Remarks:

QSAR

Vehicle controls validity:

not specified

Negative controls validity:

not specified

Positive controls validity:

not specified

Remarks on result:

positive indication of skin sensitisation

Interpretation of results:

Category 1 (skin sensitising) based on GHS criteria

Conclusions:

The skin sensitization of the target Indole was predicted employing two different in silico approaches: the QSAR statistical model as provided by Vega and the decision rule system provided by Toxtree. In the case of the target Indole, Toxtree did not identify any skin sensitization reactivity domain alert, while Vega provided a positive prediction of moderate reliability. Thus, following a conservative approach, it was concluded that the target compound Indole is predicted as SKIN SENSITIZER and the prediction was assessed as moderate reliable.

Indole is skin sensitiser. Skin sens 1. (H317) May cause an allergic skin reaction.

Executive summary:

Indole is skin sensitiser. Skin sens 1. (H317) May cause an allergic skin reaction.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (sensitising)

Additional information:

Indole is skin sensitiser. Skin sens 1. (H317) May cause an allergic skin reaction.