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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

3- Phenylpropyl acetate is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is frompeer-reviewed journal
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Acute oral toxicity study was conducted on rats for the test compound 3- Phenylpropyl acetate
GLP compliance:
no
Test type:
other: No data
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
2220, 3330, 5000 and 7000 mg/Kg
No. of animals per sex per dose:
Total: 40 2220 mg/kg :10 rats3330 mg/kg :10 rats5000 mg/kg :10 rats7000 mg/kg :10 rats
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: clinical signs and mortality
Statistics:
No data available
Preliminary study:
No data available
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 700 mg/kg bw
Based on:
test mat.
95% CL:
3 840 - 5 560
Remarks on result:
other: No effect on survival and clinical sign
Mortality:
9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing
Clinical signs:
other: When treated with 3330 and 7000 mg/kg, piloerection were observed in treated rats. When treated with 5000 and 7000 mg/kg,depression and a negative righting reflex were observed in treated rats.
Gross pathology:
No data available
Other findings:
No data available

Dose (mg/Kg)

Mortality

2220

0

3330

2

5000

6

7000

9
Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
Executive summary:

In a acute oral toxicity study, group of 10 rats were treated with 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
4 700 mg/kg bw
Quality of whole database:
Data is Klimisch 2 and from peer-revieed journal

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer-reviewed journal
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Acute dermal toxicity study was conducted on rabbits to evaluate toxic nature of 3- Phenylpropyl acetate.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available
Type of coverage:
other: dermally
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/Kg
No. of animals per sex per dose:
10 rabbits
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: Mortality and clinical sign were observed.
Statistics:
No data available
Preliminary study:
No data available
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No effect on survival and clinical sign
Mortality:
When treated wtih 5000 mg/kg bw, 1 rabbit were died.
Clinical signs:
other: No clinical signs of toxicity were observed in treated rabbits.
Gross pathology:
No data available
Other findings:
No data available
Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
Executive summary:

In a acute dermal toxicity study, group of 10 rabbits were treated with 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
Data is Klimisch 2 and from peer-revieed journal

Additional information

Acute oral toxicity:

Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) for acute oral toxicity is summarized below

In a study given by McGintyet al(2012) and Morenoet al(1979), acute oral toxicity was evaluated in group of 10 rats by using 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.

In a study given by Belsitoet al(2012), acute oral toxicity was evaluated in 10 rats by using 3- Phenylpropyl acetate in the concentration of 4700 orally. 50 % mortality was observed at 4700 mg/kg bw.. Therefore, LD50 was considered to be 4700 mg/kg (3800-5600) when rats were treated with 3- Phenylpropyl acetate orally.

Thus, Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) is likely to be non hazardous by oral route of exposure in rats.

Acute dermal toxicity:

Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and it’s 80-90% similar read across benzyl acetate (CAS no 144-11-4) for acute dermal toxicity is summarized below

In a study given by McGintyet al(2012), acute dermal toxicity was evaluated in group of 10 rabbits by using 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.

In a study given by Morenoet al(1979), acute dermal toxicity was evaluated in group of rabbits by using Phenylpropyl acetate in the concentration of 5000 mg/Kg orally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Phenylpropyl acetate dermally.

In a study given by McGintyet al(2012), acute dermal toxicity was evaluated rabbits treated with benzyl acetate in the concentration of 5000 mg/kg bw dermally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with benzyl acetate topically.

Thus, Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and its 80-90% similar read across benzyl acetate (CAS no 144-11-4) is likely to be non hazardous by dermal route of exposure in rabbits.

Justification for selection of acute toxicity – oral endpoint

LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.

Justification for selection of acute toxicity – dermal endpoint

LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.

Justification for classification or non-classification

Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and its 80-90% similar read across benzyl acetate (CAS no 144-11-4) is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.