Registration Dossier
Registration Dossier
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EC number: 204-593-9 | CAS number: 123-03-5
Endpoint summary
Administrative data
Description of key information
The substance is moderately irritating to the skin and causes severe damage to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an OECD guideline study, CPC resulted in a Primary Dermal Irritation Index of 4.9, and is thus considered a moderate skin irritant. When instilled into the eyes of three rabbits, the substance caused severe eye damage (corneal opacity, iritis and conjuctivitis),
with sustained effects through at least 4 days.
Justification for selection of eye irritation endpoint:
experimental result
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Based on the findings in guideline in vivo studies, CPC is a moderate skin irritant and is classified as Category 2, Irritant.
It caused severe corneal opacity, iritis and conjunctivitis to the eye, and is classified as Category 1, causes serious eye damage. A STOT-SE Category 3 for respiratory irritation (H335) is also applied.
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