2,6-di-tert-butyl-p-cresol

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

No guideline was followed and no GLP. However, it provides some scientific valid information for the weight of evidence analysis.

Principles of method if other than guideline:

Solubilites of BHT were determined either by a radiotracer technique for low concentrations or by visually observing the dissolution process as the temperature of a mixture is changed.

GLP compliance:

not specified

Key result

Medium:

other: n-heptane

Solubility:

55.9 other: wt %

Temp.:

29.5 °C

Key result

Medium:

ethanol

Solubility:

34 other: wt %

Temp.:

28.7 °C

Key result

Medium:

n-octanol

Solubility:

31.1 other: wt %

Temp.:

29.5 °C

Test substance stable:

not determined

Conclusions:

The solubility of BHT in various solvents was measured as follows:
Solubility of BHT in n-heptane at 29.5 ºC is 55.9 wt%
Solubility of BHT in ethanol at 28.7 ºC is 34 wt%
Solubility of BHT in 1-octanol at 29.5 ºC is 31.1 wt%

Executive summary:

The solubility of BHT in various solvents was measured as follows:

Solubility of BHT in n-heptane at 29.5 ºC is 55.9 wt%

Solubility of BHT in ethanol at 28.7 ºC is 34 wt%

Solubility of BHT in 1-octanol at 29.5 ºC is 31.1 wt%

Reference 2

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Peer reviewed data.

Principles of method if other than guideline:

No data provided on the test method.

GLP compliance:

not specified

Freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.

Conclusions:

Freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.

Executive summary:

Freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.

Description of key information

 Based on the data included in the handbook, BHT is freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.

 

Based on the experimental results from the scientific article, the solubility of BHT in various solvents was measured as follows:

Solubility of BHT in n-heptane at 29.5 ºC is 55.9 wt%

Solubility of BHT in ethanol at 28.7 ºC is 34 wt%

Solubility of BHT in 1-octanol at 29.5 ºC is 31.1 wt%

Additional information

Weight of evidence: Experimental results from a handbook and a scientific article.