Registration Dossier
Registration Dossier
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EC number: 206-839-0 | CAS number: 381-73-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Using the weight of evidence approach; the bio-accumulation potential of difluoroacetic acid which belongs to the similar category of chemicals “Dihaloacetates” (as do the read across chemicals Dichloroacetic acid (DCA) and Dibromoacetic acid (DBA)); the bio-accumulation potential of the target chemical difluoroacetic acid appears to be high. The reasons have been discussed in the discussion section, also the Bio-accumulation potential of difluoroacetic acid appears to be high.
Key value for chemical safety assessment
- Bioaccumulation potential:
- high bioaccumulation potential
Additional information
The toxicity and the metabolism ofdifluoroacetic acid has not been investigated in details and hence there is lack of literature on the same. However, after reading across from analogue chemicals dichloroacetic acid (DCA)and dibromoacetic acid (DBA), it is evident that DCA is eliminated at half the rate compared to DBA. This could be related to the reactivity of the halogens that decreases in the order fluorine > chlorine > bromine > iodine.
Thus, chlorine being more reactive than bromine is bound within the living system and eliminated out of the body slowly. Applying this rule, it shall follow thatdifluoroacetic acid shall be slowest in being eliminated out of the living system and thereby having a tendency to bio-accumulate. The chemical is also known to be a nephron-toxicantalthough the mechanism of DFA-induced nephrotoxicity is not understood.
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