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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
9 577 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
26 590 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
4 353 mg/kg bw

Additional information

Oral Toxicity

The acute oral toxicity of Norbornene was determined in groups of 5 male Carworth-Wistar rats, each receiving an oral dose of the test substance by gavage. Dosage range was spaced in a logarithmic spacing of a factor 2. The observation period was 14d. The LD50 was determined with a range of +/-1.96 standard deviations according to the calculation method of Thomson (1947). Overall the study was conducted similar to OECD 401 (retracted). The acute oral LD50 was 9577 mg/kg b.w. in male rats (Smyth, 1969)

Dermal Toxicity

the acute dermal toxicity was determined in groups of 4 male albino New Zealand rabbits, each receiving a graduate single dose of test substance followed by 24h occlusive wrapping and 14 d observation. From mortality data the LD50 was calculated as > 5 ml/kg corresponding to > 4353 mg/kg. (Smyth, 1969)

Inhalative toxicity

In an acute inhalation toxicity study, norbonene was applied as an aerosol at 26.59 mg/l air to groups of 5 young adult male and female Wistar rats in an nose only type of experiment. The animals observed for 14d. Clinical symptons were reversible within two days. Two male rats dies shortly after exposure. The combined LC50 > 26.59 mg/l air. (Hofmann, 1995)

Justification for classification or non-classification

in dermal and inhalative acute toxicity testing the dose range did not suffice to determine LD50 values. The observed values are LD50: oral 9577 mg/kg; dermal > 4353 mg/kg, inhalative >26.59 mg/l (aerosol)

Based on these values, no classification according to EU criteria is required.