Registration Dossier
Registration Dossier
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EC number: 208-754-4 | CAS number: 540-72-7
Carcinogenicity
Administrative data
Description of key information
Thiocyanates are ubiquitous in living nature. Thiocyanates are not genotoxic, and there is no evidence from repeated dose studies that thiocyanate is able to induce hyperplasia and/or pre-neoplastic lesions.
Key value for chemical safety assessment
Justification for classification or non-classification
Available information indicates that thiocyanates are not genotoxic and do not lead to hyperplasia and/or pre-neoplastic lesions, and thus do not need to be classified.
Additional information
A chronic study (Lijinsky W, Kovatch RM Toxicol Ind Health 1989 Jan 5:1 25-9) in rats supplied with 0.32% thiocyanate together with sodium nitrite (0.2%) in their drinking water for at least for 2 years, showed no effects in survival, or in the incidence of any tumor that could be related to the treatment.
Thiocyanates are naturally occurring substances with ubiquitous presence in living nature. Many studies evaluated the background thiocyanate levels in serum of man showing levels between 23 to 50 µmol/L to up to 100 µmol/L in case of smokers. Thiocyanates are not genotoxic, and there is no evidence from repeated dose studies that thiocyanate is able to induce hyperplasia and/or pre-neoplastic lesions.
In view of the available information, further studies to evaluate possible carcinogenicity of Thiocyanates are not justified.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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