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EC number: 211-708-6 | CAS number: 688-84-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
WoE evaluation based on two valid acute studies with Daphnia magna (MoE, 1998) and (Safepharm 1995): 48 h-EC50 = 2.18 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.18 mg/L
Additional information
Acute toxicity data of the substance to daphnia are available from four different test reports, 2 acute guideline studies with Daphnia magna and 48 h toxicity data from two chronic invertebrate studies. The two acute studies have deficiencies because of the use of /solvent/dispersant in order to overcome the limited solubility of the test material. In addition, the two results are not very consistent.
In the first one (MoE 1998) several of the concentrations tested were above the solubility limit in pure water, and the obtained EC50-48h is about 5.6 mg/L. In the second one (Safepharm 1995), a solvent (DMF) was used to help to dissolve the substance in the medium. Although use of solvent is not encouraged, DMF is among those listed in the OECD "Guidance document on aquatic toxicity testing of difficult substances and mixtures" (OECD, 2000). The EC50 -48h in this study was 0.85 mg/L.
As the two results are not very consistent, further information can be drawn from the two chronic studies in order to gain more confidence in the evaluation. In both studies the toxicity of 2-EHMA to the parental Daphnia was monitored. In one reproduction toxicity test (Fraunhofer 2004, see section 6.1.4) there was no toxicity to parental daphnia after 48 h of exposure up to the highest test concentration of 2.75 mg/L. At the same concentration 80 % of the parental daphnids were immobilised after 72h. This is consistent with the results of the other Daphnia reproduction study where no immobilisation was observed after 48 h at 2.2 mg/L (nominal/1.51 mg/L(measured) while 40 % immobilisation of the parental daphnids were observed at 5 mg/L (nominal) /3.82 mg/L(measured). The results of these two tests are consistent and indicate that the 48h-EC50 is more likely in a range between 2 and 3 mg/L. Therefore, the geometric mean of the two acute studies is used as the relevant parameter for the assessment: 2.18 mg/L.
There are no data on the toxicity of 2-EHMA to marine invertebrates, but studies with the common metabolite of the category, methacrylic acid, indicate that marine species are not expected to be more sensitive to methacrylates than freshwater species (Sverdrup, 2001).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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