1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Endpoint summary

Description of key information

skin irritation (OECD 404): not classified
eye irritation (OECD 405): not classified

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Additional information

Skin

Skin irritation by triallyl isocyanurate was evaluated in a GLP study according to OECD guideline 404 (2003-0178-DGT). 0.5 mL test item was applied to the shaved skin of 3 Himalayan rabbits under semi-occlusive conditions for 4 hours. In one animal erythema of grade 1 were noted at the 24, 48 and 72 h and 4 day reading time point. No further skin reactions were noted in any of the animals. Thus, the mean scores out of all 3 animals over 24, 48 and 72 h were 0.3 and 0 for erythema and edema, respectively. No systemic toxicological reactions were noted.

Under the conditions of this GLP guideline study triallyl isocyanurate is considered not to be irritating to skin.

In a non-guideline study with one single rabbit, repeated applications of 15% triallyl isocyanurate for 3 consecutive days on the abraded abdomen as well as the response to 10 applications of 15% triallyl isocyanurate over 14 days to the ear and intact abdomen were examined (TSCA Section 8(e), Doc-ID 88-920002607). Readings were performed on each application day and thereafter on day 15 and 21 using a 6-grade scoring system for hyperemia, edema, necrosis, exfoliation, hair loss, scab and scar. Slight hyperemia (grade 3) was observed after test substance application on the intact and abraded abdomen. However this skin response was reversible after treatment had stopped. Slight exfoliation (grade 3) was noted on the intact and abraded abdomen starting from day 7. On the ear slight hyperemia (grade 3) was observed on day 9 as well as slight exfoliation (grade 3) on day 7, 14 and 21. In conclusion, repeated prolonged exposures to triallyl isocyanurate may cause slight irritation.

Eye

Eye irritation by triallyl isocyanuarate was examined in a GLP study according to OECD guideline 405 (2003-0180-DGT). 0.1 mL test item was instilled into the the right eyes of 3 Himalayan rabbits (no washout). The untreated left eye of each animal served as control. The eye reactions were examined 1, 24, 48 and 72 h after application and resulted in mean scores of 0 for corneal opacity, iris, conjunctival redness and chemosis, respectively. The fluorescein test 24 h after test item instillation revealed no pathological findings. There were no systemic intolerance reactions.

Under the conditions of this study, triallyl isocyanurate is considered not to be an irritant to eyes.

In a poorly reported non-guideline study, triallyl isocyanurate was instilled in both eyes of one male rabbit (TSCA Section 8(e), Doc-ID 88-920002607). The right eye was rinsed after 30 sec and the left eye was washed after the first fluorescein staining of the eye at the 1 h reading time point. Further readings were performed immediately after instillation as well as 24 h, 48 h and 7 days after test item application using a 6-grade scoring system with grade 1 indicating no effect and grade 6 representing severe reactions.

Immediately after test substance application a slight conjunctivae response (grade 3) was observed in both eyes. At the 1 h reading time point, pupils did not react properly. In addition, the degree of of constrictions was much less than normal. The slight conjunctivae response (grade 3) observed immediately after treatment was still present after 1 h in both eyes and persisted in the right eye to 24 h after treatment. At the 48 h reading time point the pupils were normal and no more response on conjunctivae was noted in the right eye. No corneal and iris response was observed at any reading time point. In conclusion, under the conditions of this non-guideline study slight transient conjunctival irritation was observed.

 

Justification for classification or non-classification

The available data on skin and eye irritation of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.