Registration Dossier
Registration Dossier
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EC number: 215-223-0 | CAS number: 1314-15-4
Endpoint summary
Administrative data
Description of key information
According to a brief summary in an Expert Group report (DECOS, 2008) of a 40-year-old study, male Sprague-Dawley rats received platinum(IV) oxide in the diet at a level corresponding to a dose of about 815 mg/kg bw/day for 4 weeks. No effect on growth was apparent (Holbrook, 1976; Holbrook et al., 1976). Marginal effects on a small number of clinical chemistry parameters [likely including aniline hydroxylase and cytochrome b5 activity] were noted following such treatment (Holbrook et al., 1976).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
According to a brief summary in an Expert Group report (DECOS, 2008) of a 40-year-old study, male Sprague-Dawley rats received platinum(IV) oxide in the diet at a level corresponding to a dose of about 815 mg/kg bw/day for 4 weeks. No effect on growth was apparent (Holbrook, 1976; Holbrook et al., 1976). Marginal effects on a small number of clinical chemistry parameters [likely including aniline hydroxylase and cytochrome b5 activity] were noted following such treatment (Holbrook et al., 1976).
References (not included elsewhere in this IUCLID dossier)
DECOS (2008). Dutch Expert Committee on Occupational Standards. Platinum and Platinum Compounds. Health-based recommended occupational exposure limit. Gezondheidsraad, 2008/12OSH.https://www.gezondheidsraad.nl/en/publications/gezonde-arbeidsomstandigheden/platinum-and-platinum-compounds-health-based-recommended
Holbrook DJ (1976). Assessment of toxicity of automotive metallic emissions. vol 1: Assessment of fuel additives emission toxicity via selected assays of nucleic and protein synthesis, Research Triangle Park, North Carolina, US Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratories, 67 pp (EPA/600/1-76/010a) [cited in DECOS, 2008].
Holbrook DJ et al. (1976). Effects of platinum and palladium salts on parameters of drug metabolism in rat liver. J Toxicol Environ Health 1:1067-1079 [cited in DECOS, 2008].
Justification for classification or non-classification
No evidence of specific target organ toxicity was noted in the limited repeated dose studies identified. As such, classification for STOT-RE is not considered appropriate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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