Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-370-1 | CAS number: 2425-77-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 33 476 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 1 674 mg/kg bw
Additional information
Experimental studies of 5 representatives of the category of Guerbet alcohols show a very low acute oral toxicity. Mortalities were only observed after application of the shortest chain Guerbet alcohol 2 -Butyl-octan-1-ol (C12) but only at doses of about 15,000 mg/kg bw and above. No clinical symptoma were observed for Alcohols C16 -20, branched and longer chain guerbet alcohols after application of very high doses. No pathological findings were observed at dissection of the animals.
Acute dermal toxicity studies of C16 and C20 Guerbet alcohol also show a low dermal toxicity at doses of up to 2 ml/kg. The test substances were applied on intact as well as on scarificed skin with a damaged skin barrier. No deaths occurred at any of the doses applied. In case of the experiment with scarificed skin it should be considered that doses systemically available were actually much higher.
Based on the available data it can be concluded that all Guerbet alcohols of the category are of very low acute oral and dermal toxicity.
Justification for classification or non-classification
Available data are conclusive but not sufficient for classification of 2-hexyldecan-1-ol with regard to acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
