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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

4,6-dichloro-1,3,5-triazine-2(1H)-one, sodium salt is

not irritating for the rabbit skin or eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05.03 - 13.03.1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
3 Minutes and 1 Hour and 4 hours
Observation period:
72 hours
Number of animals:
3
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 0
Max. score:
1
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible
Interpretation of results:
GHS criteria not met
Conclusions:
Aquacros is classified as non-irritant
Executive summary:

NHDT was applied at intact skin of 3 female rabbits for 3 Minutes, 1 hour and 4 hours.

at all applications no to very slight erythema were observed. This leads to a classification as non-irritant.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Sept 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.1 ml Solution of 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt, 8% in Water
Duration of treatment / exposure:
1 hour
Observation period (in vivo):
24/48/72 h
Number of animals or in vitro replicates:
3
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 0
Max. score:
0
Reversibility:
fully reversible
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 0
Max. score:
0
Reversibility:
fully reversible
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 0
Max. score:
0
Reversibility:
fully reversible
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 0
Max. score:
0
Reversibility:
fully reversible
Interpretation of results:
GHS criteria not met
Conclusions:
4,6-dichloro-1,3,5-triazine-2(1H)-one, sodium salt is not irritating for the rabbit eye.
Executive summary:

Under the test conditions a single instillation of 0.1 ml 4,6-dichloro-1,3,5-triazine-2(1H)-one, sodium salt 8% in Water per animal into the conjunctival sac of the right eye of three rabbits caused the following effects:

Conjunctival redness (grade 1) was noted in all animals 1 hour after instillation. The cornea and iris werde not affected by instillatoin of the test compound. There were no systemic intollerance reactions.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for selection of skin irritation / corrosion endpoint:
well documented guideline study

Justification for selection of eye irritation endpoint:
well documented guideline study

Justification for classification or non-classification

Two guideline studies for skin an eye irritation / corrosion gave no indicaton for irritatoin or corrosive effects. Therefore 4,6-dichloro-1,3,5-triazine-2(1H)-one, sodium salt was classified "not irritating" for skin and eye.