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EC number: 221-375-9 | CAS number: 3081-14-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine (77PD) to fish (pimephales promela) was conducted in a flow-through mortality test which is similar to the later OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study). After 14 d of exposure a LC 50 value of 0.05 mg/L and after 96h a LC 50 value of 0.06mg/L was obtained,
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.06 mg/L
Additional information
Tests with fish
Obviously, fish is the most sensitive organism for the family of PPDs and their degradation products. The lowest effect values were found for 6PPD (0.028 mg/L) and for p-hydroquinone (0.044 mg/L) which is rather close to the value for 77PD (0.06 mg/L).
For 4-HDPA, N-phenylbenzoquinone-imine and 1,4-dimethylpentyl-p-aminophenol only calculated values are available. The calculated values should be used only for a rough estimation due to the high uncertainty of the method. However they show a trend: The effect values of these three intermediate compounds to fish are at a higher level and there is no indication for a higher toxicity exceeding those for 6PPD or p-hydroquinone.
Toxicity of Tyre wear particles (TWP) to fish:
TWPs are produced containing antioxidants like 7PPD in a concentration of about 1%. The toxicities of the TWP elutriates to Pimephales promelas were determined in 96-h static toxicity tests performed according to OECD Test Method 203. In this study the toxicity of such particles mixed in sediment was evaluated. Water-sediment systems are considered the likely reservoir of tire wear particles in the environment.
Under standard test temperature conditions, no response in the tested concentration range (100, 500, 1000 or 10000 mg/l TWP) was observed. LC50 values were greater than 10,000 mg/l. Based on the high LC50 values and the limited conditions under which toxicity was observed, TWP are assumed to pose a low risk to fish.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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