Titanium tetrapropanolate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

GLP compliance:

no

Remarks:

The hydrolysis rate is too fast and rigorous guideline test is not possible.

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Supplier: Borica Co., Ltd.
- Lot number: 200554x
- Expiration date of the lot/batch: 2018-May-24
- CAS number: 3087-37-4

Radiolabelling:

no

Analytical monitoring:

yes

Details on sampling:

Initial observations showed rapid degradation in minutes in diluted form.
Only performed at 'natural' pH; it is known that pH does not influence the rate of degradation of these highly unstable substances.
The concentration of test substance in the test sample was determined at time points between 0 & 60 minutes based on quantification of the hydrolysis product. Sampling point: 0, 5, 10, 25, 40, 60 min.

Buffers:

- pH: 7
Conc. 0.01 M
pH 7 Phosphate

Duration:

60 min

pH:

7

Temp.:

30 °C

Number of replicates:

2

Positive controls:

no

Negative controls:

yes

Remarks:

(Blank buffer solutions)

Preliminary study:

The hydrolysis products (transformation products) were identfied.

Transformation products:

yes

No.:

#1

Details on hydrolysis and appearance of transformation product(s):

The solution immediately became cloudy and white precipitation forms when water was added into the Test Substance, indicating the rapid hydrolysis behavior of the Test Substance.

Key result

pH:

7

Temp.:

30 °C

DT50:

<= 5 min

Validity criteria fulfilled:

yes

Conclusions:

The hydroylsis half-life of the test subsatnce was less than 5 minute.

Executive summary:

The recorded degradation products are titanium dioxide and 1-propanol.  The organic products are known to biodegrade readily.

Description of key information

Test conducted according to OECD guideline 111.

Key value for chemical safety assessment

Half-life for hydrolysis:

5 min

at the temperature of:

30 °C

Additional information

Degrades rapidly when diluted in water, with the visible formation of zirconium oxide as a precipitate within minutes of adding to water.  

Half-life not possible to measure, but considered to be less than 5 minutes.

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