Registration Dossier
Registration Dossier
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EC number: 228-067-3 | CAS number: 6107-56-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 May 2018 to 25 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < 1
- Temp.:
- 20 °C
- Remarks on result:
- other: Determination of partition coefficient is not strictly applicable to surface active substances, but the test item eluted before the first reference standard therefore the log Pow is determined to be <1.
- Details on results:
- The test item eluted at approximately the same time as the dead time standard and was seen as a partially resolve peak just next to the deadtime standard peak.
As there was no retention using the detailed HPLC conditions, it was concluded that although the method was not strictly applicable to the test item, the partition coefficient of the compound is less than that of the earliest eluting standard assessed (acetanilide) with a log10Pow value less than 1.0. - Conclusions:
- Determination of partition coefficient is not strictly applicable to surface active substances, but the test item eluted before the first reference standard therefore the log Pow is determined to be <1.
- Executive summary:
The partition coefficient of the test item was determined in an OECD 117 and EC Method A.8 guideline study, by the HPLC method. The Log Pow of the test item was determined to be <1.
The study is a GLP compliant guideline experimental study fully acceptable for assessment of this endpoint.
Reference
Description of key information
Determination of partition coefficient is not strictly applicable to this substance as it is surface active, however the Log Pow of the test item was determined to be <1.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1
Additional information
Determination of partition coefficient is not strictly applicable for surface active substances. However, an attempt has been made to determine that partition coefficient of the test item in an OECD 117 and EC Method A.8 guideline study, by the HPLC method (Dunning 2018). The study is a GLP compliant guideline experimental study fully acceptable for assessment of this endpoint. The Log Pow of the test item was determined to be <1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
