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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from NTP
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Metabolism and disposition of C.1. Pigment Red 23 in rats
GLP compliance:
not specified
Specific details on test material used for the study:
Name: 3-hydroxy-4-[(2-methoxy-5-nitrophenyl)azo]-N-(3-nitrophenyl)naphthalene-2-carboxamide
SMILES:COc1ccc(N(=O)=O)cc1N=Nc1c2ccccc2cc(C(=O)Nc2cccc(N(=O)=O)c2)c1O
InChI:1S/C24H17N5O7/c1-36-21-10-9-17(29(34)35)13-20(21)26-27-22-18-8-3-2-5-14(18)11-19(23(22)30)24(31)25-15-6-4-7-16(12-15)28(32)33/h2-13,30H,1H3,(H,25,31)/b27-26+
Molecular Formula: C24H17N5O7
Molecular Weight: 487.4263 g/mole
Radiolabelling:
no
Species:
rat
Strain:
Fischer 344
Sex:
male
Details on test animals or test system and environmental conditions:
- Age at study initiation: 7 to 8 weeks old)
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on exposure:
not specified
Duration and frequency of treatment / exposure:
single dose
Dose / conc.:
5.3 mg/kg bw/day
No. of animals per sex per dose / concentration:
not specified
Control animals:
not specified
Positive control reference chemical:
not specified
Details on study design:
not specified
Details on dosing and sampling:
not specified
Statistics:
not specified
Preliminary studies:
not specified
Type:
excretion
Results:
Nearly all of the pigment (93% ± 16%) was recovered in the feces 48 hours after administration. No pigment was found in plasma, whole blood, liver, kidney, or lungs of treated animals at any time period even after administering 10 times this dose
Details on absorption:
not specified
Details on distribution in tissues:
not specified
Details on excretion:
Nearly all of the pigment (93% ± 16%) was recovered in the feces 48 hours after administration. No pigment was found in plasma, whole blood, liver, kidney, or lungs of treated animals at any time period even after administering 10 times this dose
Metabolites identified:
no
Details on metabolites:
not specified
Bioaccessibility (or Bioavailability) testing results:
not specified
Conclusions:
C.1. Pigment Red 23 was considered to be have Low bio-accumulation potential in rats based on study results.
Executive summary:

Upon oral administration, C.1. Pigment Red 23 were Nearly all of the pigment (93% ± 16%) was recovered in the feces 48 hours after administration. No pigment was found in plasma, whole blood, liver, kidney, or lungs of treated animals at any time period even after administering 10 times this dose. Therefore, C.1. Pigment Red 23 was considered to be have Low bio-accumulation potential in rats based on study results.

Description of key information

C.1. Pigment Red 23 was considered to be have Low bio-accumulation potential in rats based on study results.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

Upon oral administration, C.1. Pigment Red 23 were Nearly all of the pigment (93% ± 16%) was recovered in the feces 48 hours after administration. No pigment was found in plasma, whole blood, liver, kidney, or lungs of treated animals at any time period even after administering 10 times this dose. Therefore, C.1. Pigment Red 23 was considered to be have Low bio-accumulation potential in rats based on study results.