Registration Dossier
Registration Dossier
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EC number: 231-210-2 | CAS number: 7447-39-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
- According to Directive 67/548/EEC: Irritant (Xi). R38, Irritating to skin.
- According to CLP/GHS: H315: Causes Skin Irritation. Category 2.
- According to Directive 67/548/EEC: Irritant (Xi). R41, risk of serious damage to eyes.
- According to CLP/GHS: Eye Damage 1, H318: Causes serious eye damage.
Acute toxicity, irritation and sensitisation data for copper dichloride have been read across from the closely analogous substance copper chloride. These substances are chemically similar; copper dichloride contains only cupric copper and ionic chlorine, whereas copper chloride contains cuprous copper and ionic chlorine. Available data on (cuprous) dicopper oxide and (cupric) copper oxide show that cuprous copper is inherently more acutely toxic and irritant than the cupric form (neither compound is a skin sensitiser). The results of an acute oral toxicity test available in the public literature (Singh and Junnarkar, 1991) confirm that this principle can also be applied to the cuprous and cupric chlorides. On this basis, and in order to minimise animal testing, a worst-case approach has been adopted in which data generated using copper choride has been directly read across to copper dichloride.
Skin irritation/corrosivity:
Based on the results of the available copper chloride skin irritation study (BASF AG, 1978b), copper dichloride could be deemed corrosive to the skin. However, the exposure period (20 h) used in this study was excessive when compared to modern guidelines. In reviewing the skin sensitisation study, although irritation was observed in the guinea pig, corrosivity was not observed at any time in the study. Taken together, it is concluded that there is insufficient evidence to classify copper dichloride as corrosive to skin. Copper dichloride is therefore classified as follows on the basis of its skin irritation potential:
Eye irritation/corrosivity:
A GLP-compliant study was conducted in the rabbit in accordance with internationally accepted guidelines (BASF AG, 1978b). Adverse effects associated with the analogous compound copper chloride were found not to be fully reversible at the end of the obseravtion period. It is therefore concluded that copper dichloride is classified as follows on the basis of eye irritation/corrosivity:
These classification criteria are applicable to anhydrous and hydrated forms of the compound.
Justification for classification or non-classification
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