Registration Dossier
Registration Dossier
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EC number: 231-665-7 | CAS number: 7681-38-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Sodium hydrogensulfate can safely be expected to dissociate under physiological conditions to sodium and sulfate ions, whoch is why read across to these ions is considered reasonable. Skin sensitisation of sulfuric acid and sodium sulfate however unlikely, since the human body contains large amounts of sodium and sulfate ions, experience from occupational exposure and human patch testing to sulfuric acid did not elicit any allergic reactions, and experimental testing of sodium sulfate has failed to elicit any skin sensiting reaction.
Migrated from Short description of key information:
Sodium hydrogensulfate can safely be expected to dissociate under physiological conditions to sodium and sulfate ions, whoch is why read across to these ions is considered reasonable. Skin sensitisation of sulfuric acid and sodium sulfate however unlikely, since the human body contains large amounts of sodium and sulfate ions, experience from occupational exposure and human patch testing to sulfuric acid did not elicit any allergic reactions, and experimental testing of sodium sulfate has failed to elicit any skin sensiting reaction.
Furthermore, the test findings in an adjuvant sensitisation test (M&K-test) in guinea pigs and in accordance to Regulation (EC) No 1272/2008, sodium sulphate does not have to be classified as a skin sensitizer.
Based on the read-across concept it can be concluded that sodium hydrogensulfate does not have sensitising properties.
Justification for classification or non-classification
Based on testing of sodium sulfate in an adjuvant sensitisation test (M&K-test) in guinea pigs, and by way of read-across from sodium sulfate and sulfuric acid to sodium hydrogensulfate, sodium hydrogensulfate does not require classification for skin or respiratiory sensitisation.
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