Registration Dossier
Registration Dossier
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EC number: 231-999-3 | CAS number: 7783-47-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Selected endpoints for the human health hazard assessment are addressed by read-across, using a combination of data on the fluoride moiety and the tin moiety (or one of its readily soluble salts). This way forward is acceptable, since tin difluoride dissociates to the fluoride anion and the tin cation upon dissolution in aqueous media.
Once the individual constituents of tin difluoride become bioavailable (i.e. in the acidic environment in the gastric passage or after phagocytosis by pulmonary macrophages), the “overall” toxicity of the dissociated substance can be described by the toxicity of the “individual” constituents. Since synergistic effects are not expected, the human health hazard assessment consists of an individual assessment of the tin cation and the fluoride anion.
Tin difluoride readily dissociates to the corresponding tin cations and fluoride anions. The tin cation and the fluoride anion are considered to represent the overall toxicity of tin difluoride in a manner proportionate to the fluoride and the metal (represented by one of its readily soluble salts). Based on the above information, unrestricted read-across is considered feasible and justified.
Effects on developmental toxicity
Additional information
Selected endpoints for the human health hazard assessment are addressed by read-across, using a combination of data on the fluoride moiety and the tin moiety (or one of its readily soluble salts). This way forward is acceptable, since tin difluoride dissociates to the fluoride anion and the tin cation upon dissolution in aqueous media.
Once the individual constituents of tin difluoride become bioavailable (i.e. in the acidic environment in the gastric passage or after phagocytosis by pulmonary macrophages), the “overall” toxicity of the dissociated substance can be described by the toxicity of the “individual” constituents. Since synergistic effects are not expected, the human health hazard assessment consists of an individual assessment of the tin cation and the fluoride anion.
Tin difluoride readily dissociates to the corresponding tin cations and fluoride anions. The tin cation and the fluoride anion are considered to represent the overall toxicity of tin difluoride in a manner proportionate to the fluoride and the metal (represented by one of its readily soluble salts). Based on the above information, unrestricted read-across is considered feasible and justified.
Justification for classification or non-classification
Additional information
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