Registration Dossier
Registration Dossier
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EC number: 232-311-4 | CAS number: 8002-50-4 Extractives and their physically modified derivatives such as proteins, carbohydrates, lipids, nucleic acids, inorganic ions, etc. obtained from Brevoortia tyrannis.
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the ECOSAR Class (Esters) and the Neutral Organic Structure Analysis Relationship (baseline toxicity).
- Specific details on test material used for the study:
- SMILES : CCCCCCCCCCCCCCCC(=O)(OCC(COC(=O)(CCCCCCCC=CCC=CCCCCC))OC(=O)(CCCCCCCCCCCCCCCCCCC)); MOL FOR: C57 H106 O6; MOL WT : 887.48; Log Kow: 23.506 (EPISuite Kowwin v1.68 Estimate); Wat Sol: 1.619E-020 (mg/L, EPISuite WSKowwin v1.43 Estimate); Calculation is based on the structure and / or properties of oils, menhaden.
- Analytical monitoring:
- not required
- Test type:
- other: Calculation
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0 mg/L
- Basis for effect:
- mortality (fish)
- Details on results:
- Asterisk designates: Chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The lowest calculated LC50 to fish for oils, menhaden is 3.27e-011 mg/L.
- Executive summary:
The short-term toxicity to fish is calculated by ECOSAR v1.11. Lowest LC50 value for fish, 96 h, is 3.27E-11 mg/L derived by calculation from ECOSAR class Esters. The calculated LC50 Neutral Organic Structure Analysis Relationship (baseline toxicity) for fish is 3.54E-17 mg/L. Since the estimated partition coefficient (LogKow=23.506) is greater than the endpoint specific cut-off (LogKow=5.0), no effects at saturation are expected for this endpoint.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Reference
Description of key information
The short-term toxicity to fish is calculated by ECOSAR v1.11. Lowest LC50 value for fish, 96 h, is 3.27E-11 mg/L derived by calculation from ECOSAR class Esters. The calculated LC50 Neutral Organic Structure Analysis Relationship (baseline toxicity) for fish is 3.54E-17 mg/L. Since the estimated partition coefficient (LogKow=23.506) is greater than the endpoint specific cut-off (LogKow=5.0), no effects at saturation are expected for this endpoint.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Key value for chemical safety assessment
Additional information
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