Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Link to relevant study records
Reference
Endpoint:
toxicity to reproduction
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Reproductive effects observed:
not specified
Effect on fertility: via oral route
Endpoint conclusion:
no study available
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.

Testing HfCl4 for long term toxicity and then reprotoxicity, is for this reason not relevant at all, but degradation products have to be considered.

Hydrogen chloride was already registered in the frame of REACh and is not classified for reprotoxicity.

HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.

For these reasons, no study was performed with HfCl4 and all concerned endpoints are waived.


Short description of key information:
On the basis of column 2 of REACH annex VIII, and in accordance with REACH Annex XI, section 2, testing is technically not feasible since the registered substance is not stable and degrades instantaneously. In these conditions, the toxicity to the reproduction is not relevant and the substance needs to be estimated considering the toxicity of its degradation products, that is to say HCl and HfOCl2/ HfO2.

Effects on developmental toxicity

Description of key information
On the basis of column 2 of REACH annex VIII, and in accordance with REACH Annex XI, section 2, testing is technically not feasible since the registered substance is not stable and degrades instantaneously. In these conditions, the toxicity to the reproduction is not relevant and the substance needs to be estimated considering the toxicity of its degradation products, that is to say HCl and HfOCl2/ HfO2.
Link to relevant study records
Reference
Endpoint:
developmental toxicity
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Abnormalities:
not specified
Developmental effects observed:
not specified
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.

Testing HfCl4 for long term toxicity and then reprotoxicity, is for this reason not relevant at all, but degradation products have to be considered.

Hydrogen chloride was already registered in the frame of REACh and is not classified for reprotoxicity.

HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.

For these reasons, no study was performed with HfCl4 and all concerned endpoints are waived.

Justification for classification or non-classification

Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.

Testing HfCl4 for toxicity to the reproduction is for this reason not relevant at all, in the same way, no classification is needed.

Nevertheless, degradation products have to be considered, and they are already classified :

- Hydrogen chloride was registered in the frame of REACh in 2010 and is not classified for reprotoxicity.

- HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.

Additional information