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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-066-7 | CAS number: 13598-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.94 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 220.4 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Route-to-route extrapolation is applied in accordance with the ECHA REACH Guidance on Information Requirements R8 by dividing by the 8-hr respiratory volume of the rat (0.38 m3/kg bw), and corrected for light activity of the worker (6.7 m3/ 10 m3). The derived concentration is corrected for differences in oral and inhalation absorption with a default factor of 2, in accordance with the ECHA REACH Guidance, arriving at a NOAEC worker of 220.4 mg/m3.
- AF for dose response relationship:
- 1
- Justification:
- default factor for dose response relationship
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- allometric scaling is included in route-to-route extrapolation
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining interspecies differences
- AF for intraspecies differences:
- 5
- Justification:
- default factor for intraspecies differences for workers
- AF for the quality of the whole database:
- 1
- Justification:
- DNEL is derived from a reliable OECD 422 study
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.83 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Route-to-route extrapolation is applied in accordance with the ECHA REACH Guidance on Information Requirements R8. Based on the toxicokinetic assessment it is assumed that dermal absorption is similar to oral absorption and therefore no additional assessment factor had to be applied.
- AF for dose response relationship:
- 1
- Justification:
- default factor for dose response relationship
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default factor for allometric scaling from rat to human
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining interspecies differences
- AF for intraspecies differences:
- 5
- Justification:
- default factor for intraspecies differences for workers
- AF for the quality of the whole database:
- 1
- Justification:
- DNEL is derived from a reliable OECD 422 study
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
For systemic effects, DNELs were derived for inhalation, dermal and oral exposure using the oral OECD422 study in which a NOAEL of 250 mg/kg bw/d was obtained based on increased liver weights and increased centrilobular hepatocyte hypertrophy in males and females at the highest dose level.
No DNELs were derived for local effects, however, based on its corrosive properties and acute oral toxic effects, phosphonic acid should be regarded as a high hazard in accordance with the Guidance on Information Requirements and Chemical Safety Assessment, Part E Risk Characterisation.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.72 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 108.7 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Route-to-route extrapolation is applied by dividing by the 24-hr respiratory volume of the rat (1.15 m3/kg bw). The derived concentration is corrected for differences in oral and inhalation absorption with a default factor of 2, in accordance with the ECHA REACH Guidance, arriving at a NOAECgeneral public of 108.7 mg/m3.
- AF for dose response relationship:
- 1
- Justification:
- default factor for dose response relationhip
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor for sub-acute to chronic
- Justification:
- allometric scaling is included in route-to-route extrapolation
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining interspecies differences
- AF for intraspecies differences:
- 10
- Justification:
- default factor for intraspecies differences for general population
- AF for the quality of the whole database:
- 1
- Justification:
- DNEL is derived from a reliable OECD422 study
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.42 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Route-to-route extrapolation is applied in accordance with the ECHA REACH Guidance on Information Requirements R8. Based on the toxicokinetic assessment it is assumed that dermal absorption is similar to oral absorption and therefore no additional assessment factor had to be applied.
- AF for dose response relationship:
- 1
- Justification:
- default factor for dose response relationship
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default factor for allometric scaling from rat to human
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining interspecies differences
- AF for intraspecies differences:
- 10
- Justification:
- default factor for intraspecies differences for general population
- AF for the quality of the whole database:
- 1
- Justification:
- DNEL is derived from a reliable OECD422 study
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.42 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- default factor for dose response relationship
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default factor for allometric scaling from rat to human
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining interspecies differences
- AF for intraspecies differences:
- 10
- Justification:
- default factor for intraspecies differences for general population
- AF for the quality of the whole database:
- 1
- Justification:
- DNEL is derived from a reliable OECD422 study
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties identified
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
For systemic effects, DNELs were derived for inhalation, dermal and oral exposure using the oral OECD422 study in which a NOAEL of 250 mg/kg bw/d was obtained based on increased liver weights and increased centrilobular hepatocyte hypertrophy in males and females at the highest dose level.
No DNELs were derived for local effects, however, based on its corrosive properties and acute oral toxic effects, phosphonic acid should be regarded as a high hazard in accordance with the Guidance on Information Requirements and Chemical Safety Assessment, Part E Risk Characterisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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