Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-997-9 | CAS number: 14154-09-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.2 mg/m³
- Most sensitive endpoint:
- neurotoxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: adaptation of SCOEL TWA IOEL (SCOEL/SUM/127, June 2011)
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: SCOEL IOEL (inhalable)
- Value:
- 0.2 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- SCOEL IOEL is used for risk assessment purposes
- AF for differences in duration of exposure:
- 1
- Justification:
- SCOEL used human epidemiological data for the derivation of an IOEL
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required, since SCOEL IOEL is based on human epidemiological data in workers
- AF for other interspecies differences:
- 1
- Justification:
- not required, since SCOEL IOEL is based on human epidemiological data in workers
- AF for intraspecies differences:
- 1
- Justification:
- not required, since SCOEL IOEL is based on human epidemiological data in workers
- AF for the quality of the whole database:
- 1
- Justification:
- weight of evidence was applied in the derication of the IOEL, taking into account all available information
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.2 mg/m³
- Most sensitive endpoint:
- neurotoxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: adaptation of SCOEL TWA IOEL (SCOEL/SUM/127, June 2011)
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: SCOEL IOEL (inhalable)
- Value:
- 0.2 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- SCOEL IOEL is used for risk assessment purposes
- AF for differences in duration of exposure:
- 1
- Justification:
- SCOEL used human epidemiological data for the derivation of an IOEL
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required, since SCOEL IOEL is based on human epidemiological data in workers
- AF for other interspecies differences:
- 1
- Justification:
- not required, since SCOEL IOEL is based on human epidemiological data in workers
- AF for intraspecies differences:
- 1
- Justification:
- not required, since SCOEL IOEL is based on human epidemiological data in workers
- AF for the quality of the whole database:
- 1
- Justification:
- weight of evidence was applied in the derivation of the IOEL, taking into account all available information
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
