1-cyanoallyl acetate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Qualifier:

according to guideline

Guideline:

other: DIN 38412

Principles of method if other than guideline:

Method: DIN 38412

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

yes

Details on test solutions:

560 mg of Acroleincyanhydrin-o-acetat was weighed and dissolved in 10 ml dimethylsulphoxide (DMSO), this solution was further diluted with DMSO. 1 ml of the concentrated solutions were added to 10 l of dilution water to prepare the test solution.

Test organisms (species):

Leuciscus idus

Details on test organisms:

Fishes were obtained from a commercial hatchery. Average length and weight were 6.1 +/-0.3 cm and 1.9 +/- 0.3 g.

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test temperature:

20 +/- 1°C

pH:

7.2 - 8.0

Dissolved oxygen:

> 6.1 mg/l

Nominal and measured concentrations:

nominal: 0.32, 0.56, 1, 1.8, 3.2, 4.2 and 5.6 mg/l

Reference substance (positive control):

no

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

0.32 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

behaviour

Duration:

48 h

Dose descriptor:

LC0

Effect conc.:

0.56 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

0.75 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: (0.56-1.0)

Duration:

48 h

Dose descriptor:

LC100

Effect conc.:

1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Reported statistics and error estimates:

LC50 values and their confidence intervals were calculated by means of a parametric model developed by Kooijman (1981).

Validity criteria fulfilled:

yes

Conclusions:

Based on the results of this study the LC50 is 0.75 mg/L.

Description of key information

In a study conducted according to DIN 38412 the acute toxicity of Acrolein cyanhydrin acetate (ACA) to the fresh-water fish Leuciscus idus was investigated. The 48h LC50 was determined to be 0.75 mg/l. (nominal).