Registration Dossier
Registration Dossier
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EC number: 241-793-5 | CAS number: 17832-28-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
4-(vinyloxy)butan-1-ol is acutely harmful to fish.
Key value for chemical safety assessment
Additional information
Key information on toxicity of the substance to fish is derived from a study with the close structural analogue 2-methyl-1-(vinyloxy)propane (CAS 109 -53 -5). In this study performed according to OECD TG 203 and GLP criteria with zebra fish (D. rerio) were exposed to test substance concentrations of 0 (control), 5, 10, 22, 50 and 100 mg/L for 96 hours under semi-static conditions (24 -h test medium renewal). Test substance concentrations were analytically verified and determined at 71.4 - 92.3% of nominal at the start and 62.2 - 88.0% of nominal at the end. At test termination a LC50 of 28.3 mg/L was determined based on (geomean) measured concentrations. After correction for difference in molecular weight between the read-across source and target substances, the 96 -h LC50 for 4-(vinyloxy)butan-1-ol is 32.8 mg/L.
An acute fish toxicity study is also available for 4-(vinyloxy)butan-1-ol itself. In this study, which is performed according to the German Standard DIN 38412 part L15, groups of fish (L. idus) were exposed to 0 (control), 21.5, 46.4, 100, 215, and 464 mg/L for 96 hours under static conditions. No analytical verification of nominal test concentrations was performed. A 96 -h LC50 of 104 mg/L was determined. As no test substance analysis was performed, this study is considered as supporting information that the substance has limited toxicity to fish.
The 96 -h LC50 value of 32.8 mg/L from the study with 2-methyl-1-(vinyloxy)propane (CAS 109 -53 -5) is used for assessment.
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