Registration Dossier
Registration Dossier
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EC number: 243-473-0 | CAS number: 20030-30-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via inhalation route
- Dose descriptor:
- NOAEC
- 2 873 mg/m³
Additional information
Due to the lack of sufficient data regarding effects on fertility, data for the analogue substance 3,5,5-Trimethyl-2 -cyoclohexen-1-one (CAS No. 78-59-1) were taken into account. Male and female rats were exposed to 500 ppm (2873 mg/m³) by inhalation for three months prior to mating. No substance related effects on fertility and fetuses were found. Thus, it can be assumed, that due to the structural similarities 2,5,6- Trimethyl-2-cyoclohexen-1-one also would have no adverse effect on fertility.
Short description of key information:
Effects on fertility:
- NOAEC = 2873 mg/m^3 (rat, inhalative)
Effects on developmental toxicity
Description of key information
Developmental toxicity/teratogenicity:
- maternal: NOAEC = 0.644 mg/l = 644 mg/m^3 (rat, inhalative)
- teratogenic: NOAEC = 0.644 mg/l = 644 mg/m^3 (rat, inhalative)
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- NOAEC
- 664 mg/m³
Additional information
Due to the lack of sufficient data regarding developmental toxicity/teratogenicity, data for the analogue substance 3,5,5-Trimethyl-2 -cyoclohexen-1-one (CAS No. 78-59-1) were taken into account. In an inhalative study with rats, no substance related effects on dams and fetuses were found at doses of 0.144, 0.289 and 0.664 mg/l, so the resulting NOAEC was 0.644 mg/l or 644 mg/m^3, respectively.
Thus, it can be assumed, that due to the structural similarities 2,5,6- Trimethyl-2-cyoclohexen-1-one also would have no adverse effects on developmental toxicity/teratogenicity in the range of the tested concentrations.
Justification for classification or non-classification
Due to the results obtained in studies with the structural analogue 3,5,5-Trimethyl-2 -cyoclohexen-1-one (CAS No. 78-59-1) no classification for fertility or developmental toxicity/tertogenicity is necessary.
Additional information
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