Registration Dossier
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EC number: 243-697-9 | CAS number: 20292-08-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for for Scenedesmus subspicatus (DIN 38412, Part 9)
Key value for chemical safety assessment
Additional information
There are no studies on algal toxicity available for 2-ethylhexyl laurate (CAS No. 20292-08-4). The assessment was therefore based on a study conducted with the structurally most similar category member, for which data is available, isopropyl myristate (CAS No. 110-27-0). This is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of similarity, nearest physico-chemical properties) read-across substances were entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
This key study with isopropyl myristate (CAS No. 110-27-0) was performed as a limit test according to the EU Method C.3 and GLP (Rieche, 1995). The test organism Scenedesmus subspicatus was exposed to the test substance in a static system for 72 hours, at the nominal test concentration of 100 mg/L. The test was performed with and without separation of undissolved test substance. With undissolved test substance present, algal growth was significantly inhibited. However, when the undissolved phase was separated, no effects on growth were observed. It can, therefore, be concluded that the substance has no toxic effects on the test organism up to the limit of water solubility.
Thus, based on theabove mentioned result, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on algae are expected up tothe limit ofwater solubility for 2-ethylhexyl laurate (CAS No. 20292-08-4).
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