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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November / December 1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
Test animal, application of the test chemical, dose level
GLP compliance:
not specified
Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
Housing and feeding conditions:
The temperature of the experimental animal room was 20°C. The relative humidity was 50%. Lighting was artificial, the sequence was 12 hours light, 12 hours dark. Food and water was provided at discretion.
Type of coverage:
open
Preparation of test site:
shaved
Vehicle:
other: vaseline
Controls:
not specified
Amount / concentration applied:
200 ppm
Duration of treatment / exposure:
7 d
Observation period:
daily
Number of animals:
12
Irritation parameter:
erythema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Interpretation of results:
GHS criteria not met
Conclusions:
After daily application of the test substance 2-lauroyloxyethyltrimethylammonium chloride in vaseline no skin irritation could be observed, after one week. The test substance can be stated as non-irritating.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November / December 1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
DRAIZE test
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
Dose level
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
Housing and feeding conditions:
The temperature of the experimental animal room was 20°C. The relative humidity was 50%. Lighting was artificial, the sequence was 12 hours light, 12 hours dark. Food and water was provided at discretion.
Vehicle:
physiological saline
Controls:
yes, concurrent negative control
Amount / concentration applied:
physiological saline with 2000 ppm of the test substance 2-lauroyloxyethyltrimethylammonium chloride
Duration of treatment / exposure:
4 d
Observation period (in vivo):
daily
Number of animals or in vitro replicates:
8
Details on study design:
One minute after application the treated eye was rinsed with 10-20 mL of lukewarm physiological saline, at one half of the test animals (4 animals).
Irritation parameter:
cornea opacity score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Remarks:
even after 96h
Irritation parameter:
iris score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Remarks:
even after 96h
Irritation parameter:
conjunctivae score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Remarks:
even after 96h
Irritation parameter:
chemosis score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Remarks:
even after 96h
Interpretation of results:
GHS criteria not met
Conclusions:
After daily application of the test substance 2-lauroyloxyethyltrimethylammonium chloride in physiological saline no eye irritation could be observed, after overall 4 days. The test substance can be stated as non-irritating for the eyes.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification

The results of the above mentioned key studies for skin and eye irritation showed, that after 7 days no signs of erythema or oedema and after 4 days no signs of eye irritation/corrosion could be observed. According to Annex I in regulation (EC) No 1272/2008 of the european parliament and of the council, the test substance 2-lauroyloxyethyltrimethylammonium chloride is not classified as irritating or corrosive to the skin or the eyes.